WilliamEKarnesJr.MD

PubMed

• 25 citations
  Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments.
  Klaus Gottlieb, Marco Daperno, Keith Usiskin, Bruce E. Sands, Harris A. Ahmad
  Gut. 2020-07-22
• 368 citations
  Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis.
  William E. Karnes, I. M. Samloff, Max Siurala, Matti Kekki, Pentti Sipponen
  Gastroenterology. 1991-07-01
• 23 citations
  Role of Primary Tumor Resection Among Chemotherapy-Treated Patients with Synchronous Stage IV Colorectal Cancer: A Survival Analysis
  Walter Tsang, Argyrios Ziogas, Bruce S. Lin, Tara E. Seery, William E. Karnes
  Journal of Gastrointestinal Surgery. 2014-03-01

Journal Articles

• Role of Primary Tumor Resection Among Chemotherapy-Treated Patients with Synchronous Stage IV Colorectal Cancer: A Survival Analysis  
  Tsang, WY, Ziogas A, Lin BS, Seery TE, Karnes W, Stamos MJ, Zell JA, J Gastrointest Surg, 1/1/2014
• Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone  
  Lindor NM, Dozois R, Nelson H, Wolff B, King J, Boardman L, Wilson M, Greene MH, Karnes W, Mesa R, Welch T, Edmonson J, Limburg P, Am J Gastroenterol, 1/1/2003
• Inhibition of epidermal growth factor receptor kinase fails to suppress adenoma formation in ApcMIN mice but induces duodenal injury  
  Ritland SR, Gendler SJ, Burgart LJ, Fry DW, Nelson JM, Bridges AJ, Andress L, Karnes WE Jr (senior author), Cancer Res, 1/1/2000
• Adenoma-specific alterations of protein kinase C isozyme expression in ApcMIN mice  
  Klein IK, Ritland SR, Burgart LJ, Ziesmer SC, Roch, PC, Gendler SJ, Karnes WE Jr (senior author), Cancer Res, 1/1/2000
• Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair  
  Karnes WE Jr, J Cell Biochem, 1/1/2000
• Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells  
  Weller SG, Klein IK, Karnes WE Jr (senior author), Gastroenterology, 1/1/1999
• Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response element  
  Desai DS, Hirai SI, Karnes WE Jr, Niles RM, Ohno S, Biochem Biophys Res Comm, 1/1/1999
• Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells  
  Karnes WE Jr, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, Kaufmann SH, Gastroenterology, 1/1/1998
• Reduced COX-2 protein in colorectal cancer with defective mismatch repair  
  Karnes WE Jr, Shattuck-Brandt R, Burgart LJ, et al, Cancer Res, 1/1/1998
• P53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248 trp) on separate alleles  
  Rand A, Glenn KS, Alvares CP, White MB, Thibodeau SN, Karnes WEJr (senior author), Cancer Letters, 1/1/1996
• Src family of tyrosine kinases: A roles of c-yes in colon carcinogenesis  
  Boardman LA, Karnes WE Jr, Gastroenterology, 1/1/1995
• Epidemiology and etiology of sporadic colorectal adenocarcinoma  
  Karnes WE Jr, Curr Opin Gastroenterol, 1/1/1994
• Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha  
  Chen MC, Lee A, Karnes WE Jr, Avedian D, Sorvillo J, Soll AH, Am J Physiol, 1/1/1993
• Autonomous proliferation of colon cancer cells that coexpress transforming growth factor-alpha and its receptor  
  Karnes WE Jr, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Gazdar AF, Cuttitta F, Gastroenterology, 1/1/1992
• Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils  
  Craig PM, Territo MC, Karnes WE Jr, Walsh JH, Gut, 1/1/1992
• Positive serum antibody and negative tissue staining for Helicobacter pylori infection in subjects with atrophic body gastritis  
  Karnes WE Jr, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SWR, Walsh JH, Gastroenterology, 1/1/1991
• Elevated meal-stimulated gastrin release in subjects with Helicobacter pylori infection: Reversal by low intragastric pH  
  Karnes WE Jr, Ohning GV, Sytnik B, Kim SWR, Walsh JH, Reviews of Infectious Diseases, 1/1/1991
• Autocrine growth factors and solid tumor malignancy  
  Karnes WE Jr, Cuttitta F, Walker A., Walsh JH, West J Med, 1/1/1991
• Effects of aging on gastric acid secretion and on serum pepsinogen concentrations in healthy men and women: Relationships with serum gastrin and Helicobacter pylori i...  
  Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE Jr, Redfern JS, Feldman M, Gastroenterology, 1/1/1991
• The gastrin hypothesis Implications for selection of drug therapy  
  Karnes WE Jr, Walsh JH, J Clin Gastroenterol, 1/1/1990
• Prolonged inhibition of acid secretion causes hypergastrinemia without altering pH inhibition of gastrin release in humans  
  Karnes WE Jr, Berlin RG, Maxwell V, Sytnik B, Root JK, Walsh JH, Aliment Pharmacol Ther, 1/1/1990
• ras gene mutations in colorectal cancer  
  Karnes WE Jr, Jabobs R, Gastroenterology, 1/1/1987
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Books/Book Chapters

• Surgery of the Colon and Rectum 
  Chapter: Colorectal Neoplasms - Epidemiology & Etiology. 
  Karnes WE Jr, Boardman LAEditors: RJ Nicholls, RR Dozois.Churchill-Liviningston, London, UK1997
• Surgery of the Colon and Rectum 
  Chapter: Epidemiology and etiology of colorectal cancer. 
  Boardman LA, Karnes WE JrEditors: RJ Nicholls, RR Dozois.Churchill-Liviningston, London, UK1996
• Gut Peptides 
  Chapter: Growth factors and gastrointestinal malignancies. 
  Page 825 - 850Karnes WE JrEditors: JH Walsh G Dockrey.Raven Press, New York1994
• Gut Peptides 
  Chapter: Epidermal growth factor and transforming growth factor alpha. 
  Page 553 - 586Karnes WE JrEditors: JH Walsh G Dockrey.Raven Press, New York1994
• Debates in Gastroenterology, Volume 3 
  Chapter: C. pylori: innocent until proven guilty. 
  Page 321 - 334Karnes WE Jr, Guth PEditors: G Gitnik.Year Book Medical Publishers, Chicago, IL1990
• Campylobacter Pylori in Gastritis and Peptic Disease 
  Chapter: Perspectives. 
  Page 241 - 249Karnes WE Jr, Walsh JHEditors: M Blaser.Igaku-Shoin Medical Publishers, New York1989
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Abstracts/Posters

• Variable Recognition of Sessile Serrated Adenomas Among Colonoscopists and Pathologists - a Compounded Roadblock to Reducing Interval Colon Cancers
  Sarah L. Flores, Argyrios Ziogas, Gregory Albers, Hoda Anton-Culver, William E. Karnes, DDW, 1/1/2014
• Effect of Delay in Surgical Treatment of Colon Cancer on Survival.
  Farid Jalali, Argyrios Ziogas, Jason A. Zell, Michael J. Stamos, Hoda Anton-Culver, William E. Karnes, DDW, 1/1/2014
• PMA Induces apoptosis in the SNU-C4 colon cancer cells through caspase-9 independently of caspase-3 and -8.
  Weller SG, Penington RC, Karnes WE Jr, Gastroenterology, 1/1/2000
• Protein kinase C signals mitogenesis and ERK activation through metalloproteinase-dependent release of autocrine TGF-alpha in SNU-C4 colon cancer cells.
  Penington RC, Weller SG, Karnes WE Jr, Gastroenterology, 1/1/2000
• Protein kinase C-alpha is a target of beta-catenin/Tcf-4 transcriptional regulation.
  Desai DS, Ritland SH, Klein I, Karnes WE Jr, Gastroenterology, 1/1/2000
• Physical and functional interaction between beta-catenin and retinoic acid receptor beta.
  Desai DS, Karnes WE Jr, Gastroenterology, 1/1/2000
• Evidence for Fas ligand-mediated tumor immune evasion in a murine model of colorectal carcinogenesis.
  Chinery R, Watson AJ, Karnes WE Jr, Gastroenterology, 1/1/2000
• Applications of micro-CT imaging to study tumor neovascularization in murine models of colon cancer.
  Chinery R, Lund PE, Reyes DA, Bentley MD, Karnes WE Jr, Ritman EL, Gastroenterology, 1/1/2000
• Inhibition of epidermal growth factor receptor fails to suppress adenoma formation in APCMIN mice but induces flat hyperproliferative duodenal lesions.
  Ritland SR, Gendler, Burgart LJ, Fry DW, Nelson JM, Bridges Aj, Andress L, Karnes WE Jr, Gastroenterology, 1/1/1999
• P53 overexpression and K-ras mutation in early stage rectal cancer do not correlate with recurrence.
  Boardman L, Rand A, Batts KP, McDonnell SK, Peterson BJ, Zaheer S, Pemberton JH, Karnes WE Jr, Gastroenterology, 1/1/1999
• Potential role of cyclooxygenase-2 products on tumor immune escape.
  Chinery R, Morrow J, Lamps LW, Green DR, Karnes WEJr, Gastroenterology, 1/1/1999
• Relationship between siayl-tn (STN) antigen expression and microsatellite instability (MSI) in sporadic colorectal cancers (SCC).
  Itzkowitz SH, Shattuck R, Thibodeau S, Karnes WEJr, Burgart L, Gastroenterology, 1/1/1999
• Protein kinase C-mediated MAPK activation is mediated through autocrine EGFR activationin SNU-C4 colon cancer cells.
  Penington RC, Weller SG, Karnes WE Jr, Gastroenterology, 1/1/1999
• Apoptosis induced by phorbol ester in SNU-C4 colon cancer cells is associated with, but progresses independently of caspase-3-mediated cleavage of PKC-delta.
  Weller S, Penington R, Karnes WE Jr, Gastroenterology, 1/1/1999
• Reduced COX-2 protein expression in human colorectal cancer exhibiting defective mismatch repair.
  Karnes WE Jr, Dubois RN Jr, Shattuck-Brand R, Burgart LJ, Tester DJ, Thibodeau SN, Gastroenterology, 1/1/1998
• Distinct PKC isoforms mediate proliferative and apoptotic effects of phorbol esters in human colon cancer cell lines.
  Weller SG, Klein IK, Karnes WE Jr, Gastroenterology, 1/1/1998
• PKC agonists stimulate mitogenesis of SNU-C4 colon cancer cells by augmenting autocrine stimulation of epidermal growth factor receptor.
  Weller SG, Klein IK, Graves-Deal R, Bogatcheva G, Coffey R Jr, Karnes WE Jr, Gastroenterology, 1/1/1998
• A computerized colorectal cancer registry and risk assessment tool.
  Timmons LJ, Carlson EC, King JE, Lindor NM, Ahlquist DA, Treder CE, Karnes WE Jr, Gastroenterology, 1/1/1998
• PKC isoforms in intestinal mucosa and adenomas of APCMIN mice.
  Klein IK, Ritland SR, Ziesmer SC, Burgart LJ, Roche PC, Gendler SJ, Karnes WE Jr, Colorectal Neoplasia Group., Gastroenterology, 1/1/1998
• Prospective evaluation of urinary transforming growth factor alpha levels for predicting clinical important colorectal neoplasia.
  Kim KB, Herrington JJ, Devens ME, Grabau Cm, Klee GG, Ahlquist DA, Karnes WE Jr, Gastroenterology, 1/1/1998
• Relevance of occult nodal metastases by immunodetection in rectal cancer.
  Boardman LA, Batts KP, Rand A, Ahlquist DA, Zaheer S, Pemberton J, Karnes WE Jr, Gastroenterology, 1/1/1997
• Recurrent paraganglioma: an unusual cause of abdominal pain.
  Sorbi D, Karnes WE Jr, Am J Gastroenterol, 1/1/1997
• Immunomagnetic isolation of malignant colonocytes from stool: feasibility study in a model system.
  Limburg PJ, Ahlquist DA, Karnes WE Jr, Roche PC, Klee GG, Gastroenterology, 1/1/1996
• Role of distinct PKC isoforms in apoptosis and proliferation of colon cancer cell lines.
  Karnes WE Jr, Rand A, Gastroenterology, 1/1/1996
• PKC agonists stimulate proliferation of colon cancer cells independently of enhanced TGF-alpha release.
  Karnes WE Jr, Rand A, Gastroenterology, 1/1/1996
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