PradeepPaMammenMDFACC, FAHA, FHFSA

Heart Failure & Transplantation, Cardiovascular Disease Genetics

Professor of Internal Medicine; Alfred W. Harris, MD Professorship in Cardiology; Co-Director: UTSW Wellstone Muscular Dystrophy Reseach Center; Medical Director: Neuromuscular Cardiomyopathy Clinic; Director: Translational Research for the Advanced Heart Failure &Transplant Cardiology Program; Member of the UTSW Heart Failure, Ventricular Assist Devices, & Heart Transplant Program.

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Office
4000 Cambridge St
Ste G600
Kansas City, KS 66160
Phone+1 913-588-9600

Fax+1 214-648-1450

Summary

I am a clinician-scientist with clinical expertise in advanced heart failure, ventricular assist devices and heart transplantation. From a clinical perspective, I am one of only approximately 1,000 adult cardiologists in the US board certified in advanced heart failure/heart transplantation. I am currently an Associate Professor of Medicine, Co-Director of the UTSW Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (one of six NIH funded Centers in the country), and the Director for Translational Research for the Advanced Heart Failure and Transplant Cardiology Program at UTSW. Finally, I have developed clinical expertise in the care of patients who develop a familial or genetic form of cardiomyopathy (esp. neuromuscular-associated cardiomyopathies). In 2010, I founded and became the Medical Director of the UTSW Neuromuscular Cardiomyopathy Clinic. This clinic is only one of six adult clinics in the United States exclusively dedicated to addressing the cardiovascular needs of patients with neuromuscular disorders.

In keeping with my clinical interest in the treatment and management of patients with heart failure, I have developed significant scientific expertise in investigating the molecular mechanisms underlying heart failure and cardiac/skeletal muscle myopathies. In the Fall of 2015, Dr. Eric Olson, Chair of the UTSW Department of Molecular Biology and I became the Co-Directors of the UTSW Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center. The core mission of the Center is to rapidly develop genome editing into a viable and effective therapy for patients with Duchenne muscular dystrophy. In addition, I run a NIH R01-funded molecular laboratory focused on mechanistic studies to enhance our understanding of various signaling pathways that contribute to heart failure and cardiac/skeletal muscle myopathies.

Education & Training

University of Texas Southwestern Medical CenterFellowship, Advanced Heart Failure and Transplant Cardiology, 2003 - 2004
University of Texas Southwestern Medical CenterPost-Doctoral Fellowship, 2000 - 2004
University of Texas Southwestern Medical CenterFellowship, Cardiovascular Disease, 1998 - 2000
University of Iowa Hospitals and ClinicsResidency, Internal Medicine, 1995 - 1998
University of Wisconsin School of Medicine & Public HealthClass of 1995, MD, Outstanding Medical Student Research Award (1994), Outstanding Leadership and Service Award (1991)
University of PennsylvaniaB.S.E., Bioengineering/Electrical Engineering, 1987 - 1990

Certifications & Licensure

IA State Medical License 1995 - 2026
KS State Medical License 2023 - 2025
MO State Medical License 2023 - 2025
TX State Medical License 1998 - 2024
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Co-Director: UTSW Wellstone Muscular Dystrophy Specialized Research Center NIH U54/P50 Research Grant: Co-Recipient with Eric N. Olson, PhD
Heart Failure Society of America: Fellow Heart Failure Society of America, 2020
Recipient of a NIH-NHLBI R01 Research Grant National Institute of Health (NHLBI), 2012-2019
Alfred W. Harris, M.D. Professorship in Cardiology UT Southwestern Medical Center, 2018
UTSW Leadership Emerging in Academic Departments (LEAD) Program (Class of 2013) UT Southwestern Medical Center, 2013
Mentor to Diana Canseco PhD, recipient of an AHA Postdoctoral Research Award American Heart Association, 2011-2013
Recipient of a AHA Grant-in-Aid Award American Heart Association, 2009-2012
American Heart Association (Council on Basic Cardiovascular Sciences): Fellow American Heart Association, 2011
Mentor to Sarvjeet Singh PhD, recipient of an AHA Postdoctoral Research Award American Heart Association, 2009-2011
Recipient of a NIH Clinician Scientist Development Award National Institute of Health (NHLBI), 2005-2011
Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award American Heart Association, 2010
GlaxoSmithKline Competitive Grant Award for Young Investigators GlaxoSmithKline Research Foundation, 2005-2008
2nd Place: Cardiovascular Young Investigators’ Forum Northwestern University Feinberg School of Medicine, 2006
Finalist: Cardiovascular Young Investigators’ Forum Northwestern University Feinberg School of Medicine, 2005
American College of Cardiology: Fellow American College of Cardiology, 2005
Recipient of the Dr. Madhukar Deshmukh Award American Association of Cardiologists of Indian Origin, 2004
Finalist: Cardiovascular Young Investigators’ Forum AstraZeneca, 2004
Postdoctoral Fellowship Award Grant in Cardiovascular Medicine Pfizer Research Foundation, 2001-2004
Above and Beyond the Call of Duty Award: Recognition for compassionate care. U. of Iowa Hospitals & Clinics, 1998
Ernest O. Theilen Award: Outstanding CCU resident of the year. U. of Iowa Hospitals & Clinics, 1998
Outstanding Medical Student Research Award U. of Wisconsin School of Medicine, 1994
Outstanding Leadership and Service Award U. of Wisconsin School of Medicine, 1991
Eta Kappa Nu National Electrical Engineering Honor Society, 1987
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
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Publications & Presentations

PubMed

Right atrial pressure torsades de pointes.
Hadi Beaini, Alpesh A Amin, Pradeep P A Mammen, Faris G Araj
The Journal of Invasive Cardiology. 2024-01-01
1 citations
Accurate Classification of Cardiomyopathy Diagnosis by Chromatin Accessibility.
Samadrita Bhattacharyya, Jialei Duan, Ryan J Vela, Minoti Bhakta, Pietro Bajona
Circulation. 2022-09-13
14 citations
A humanized knockin mouse model of Duchenne muscular dystrophy and its correction by CRISPR-Cas9 therapeutic gene editing.
Yu Zhang, Hui Li, Takahiko Nishiyama, John R McAnally, Efrain Sanchez-Ortiz
Molecular Therapy. Nucleic Acids. 2022-09-13

Lectures

Management of Duchenne muscular dystrophy-associated cardiomyopathy.
Action Duchenne International Conference-2015 (London, UK) - 11/6/2015
Circulating microRNAs in cardiomyopathy
CareDx Inc. (San Francisco, CA) - 10/26/2015
Development of atrophic cardiomyopathy in neuromuscular disorders: A novel mode of maladaptive cardiac remodeling.
Senator Paul D. Wellstone Muscular Dystrophy Center Network Conference (U. of Washington-Seattle) - 10/14/2015
Neuromuscular Cardiomyopathies: A novel form of maladaptive cardiac remodeling.
Transplantation 2015: Advances in Solid Organ and Bone Marrow Transplantation (UT Southwestern) - 8/27/2015
The role of the epicardium in modulating cardiac remodeling.
GlaxoSmithKline (Philadelphia, PA) - 8/17/2015
Heart Transplant & VAD Grand Rounds: Molecular medicine and heart transplantation.
Baylor-St. Luke’s Medical Center (Houston, TX) - 4/24/2015
Muscular dystrophies and mitochondrial myopathies.
International Society for Heart & Lung Transplantation (Nice, France) - 4/15/2015
Cardiology Grand Rounds: Induction of reverse cardiac remodeling and the management of advanced heart failure.
University of Miami (Miami, FL) - 1/9/2015
Annual Ark-La-Tex Cardiovascular Conference: Therapeutic approaches to advanced cardiomyopathy: The optimal time to refer to a VAD/Heart Transplant Center.
LSU Health Sciences Center (Shreveport, LA) - 8/2/2014
Cardiology Clinical Conference: Novel insights into maladaptive cardiac remodeling in muscular dystrophy patients.
University of Iowa Hospitals & Clinics (Iowa City, IA) - 10/14/2013
Insights into heart failure from the animal laboratory.
American Heart Association 2012 Scientific Sessions (Los Angeles, CA) - 11/6/2012
Cardiology Grand Rounds: The crossroadsbetween molecular medicine & advanced CHF.
UCLA Medical Center (Los Angeles, CA) - 3/2/2012
Transcriptional regulation and functional roles of cytoglobin within the failing heart.
XVI International Conference of Oxygen Binding and Sensing Proteins (Antwerp, Belgium) - 8/22/2010
Role of hypoxia and exercise in the regulation of myoglobin expression.
2nd International Conference on Respiratory Science (Bonn, Germany) - 8/11/2009
Cardiology Grand Rounds: Cytoglobin: A novel calcineurin-dependent stress protein in the heart.
University of Iowa Hospitals & Clinics (Iowa City, IA) - 1/25/2006
Cardioprotective roles of myoglobin within the heart.
Johns Hopkins University School of Medicine (Baltimore, MD) - 4/19/2005
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Authored Content

The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organizationJanuary 2021

Press Mentions

Catabasis Pharmaceuticals Presents Information on Edasalonexent, a Potential Foundational Therapy for Duchenne Muscular Dystrophy, at the Virtual 25th International Congress of the World Muscle SocietySeptember 28th, 2020
Cracking the Code. Transforming Health in TexasJanuary 14th, 2019
Catabasis, UT Southwestern Collaborate to Explore Effect of Edasalonexent on Heart Function in Muscular DystrophiesNovember 19th, 2018
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Grant Support

UTSW Wellstone Musuclar Dystrophy Center: Myoediting of Duchenne muscular dystrophy.National Institute of Health (U54/P50 Research Grant: Wellstone Muscular Dystrophy Specialized Research Centers)2015–2025
Autoantibodies in DMD-Associated CardiomyopathyCatabasis Inc2020–2021
Therapeutic effects of NF-kB inhibition in the treatment of DMD-associatedCatabasis Inc.2018–2021
Role of VIP Signaling in DMD-Associated CardiomyopathyPhaseBio Inc.2017–2021
Cytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte survival.National Institute of Health (R01 Research Grant; NHLBI)2012–2019
Discovery of Unique MicroRNA Signatures in Muscular Dystrophy PatientsHeart Failure Society of America2015–2016
Cytoglobin: A Stress-Responsive Hemoprotein Modulating Cardiomyocyte SurvivalNational Heart, Lung, And Blood Institute2012
Cytoglobin modulates the fate and viability of cardiac progenitor cells within the stressed heart.American Heart Association (South Central Grant-in-Aid Award)2009–2012
Regulation of tissue hemoglobins in the heart.National Institute of Health (K08 Research Grant; NHLBI)2005–2011
Regulation Of Tissue Hemoglobins In The HeartNational Heart, Lung, And Blood Institute2005–2009
Transcriptional regulation & functional roles of cytoglobin in the heart.American Heart Association (Texas Affiliate Beginning Grant-in-Aid Award)2005–2007
Transcriptional regulation & functional roles of cytoglobin in the heart.GlaxoSmithKline Research Foundation2005–2007
Cardioprotective role of myoglobin in the heart.Donald W. Reynolds Cardiovascular Clinical Research Program2004–2006
Molecular mechanisms of cardiac dysfunction in cytochrome c oxidase subunit VIaH deficient mice.Pfizer Research Foundation2001–2004