PeterDHigginsMDPhD, MSc(CRDSA)

PubMed

• 150 citations
  Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis
  William J. Sandborn, Subrata Ghosh, Julián Panés, Stefan Schreiber, Geert R. D'Haens
  Gastroenterology. 2020-06-01
• 58 citations
  Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Crohn's Disease.
  Bruce E. Sands, Laurent Peyrin-Biroulet, Jaroslaw Kierkus, Peter D.R. Higgins, Monika Fischer
  Gastroenterology. 2021-11-05
• 51 citations
  Etrolizumab versus adalimumab or placebo as induction therapy for moderately to severely active ulcerative colitis (HIBISCUS): two phase 3 randomised, controlled trials.
  David T. Rubin, Iris Dotan, Aaron DuVall, Yoram Bouhnik, Graham L. Radford-Smith
  The Lancet. Gastroenterology & Hepatology. 2021-11-16

Journal Articles

• Developing a Standard Set of Patient-Centred Outcomes for Inflammatory Bowel Disease—an International, Cross-Disciplinary Consensus  
  Peter D Higgins, Corey A Siegel, Bruce E Sands, Journal of Crohn's and Colitis
• Comparison of Noncontrast MRI Magnetization Transfer and T2-Weighted Signal Intensity Ratios for Detection of Bowel Wall Fibrosis in a Crohn’s Disease Animal model  
  Dillman, J.R., Swanson, S.D., Johnson, L.A., Moons, D.S., Adler, J., Stidham, R.W., Higgins, P.D.R., J Mag Res Imaging, 1/1/2015
• The risk of post-ERCP pancreatitis and the protective effect of rectal indomethacin in cases of attempted but unsuccessful prophylactic pancreatic stent placement  
  Choksi, N, Fogel, EL, Cote, GA, Romagnuolo, J, Elta, GH, Scheiman, JM, Chak, A, Mosler, P, Higgins, PDR, Korsnes, SJ, Schmidt, SE, Sherman, S, Lehman, GA, Elmunzer, BJ, Gastrointestinal Endoscopy, 1/1/2015
• Increased Ultraviolet Light Exposure is Associated With Reduced Risk of Inpatient Surgery Among Patients With Crohn’s Disease  
  Govani, SM, Higgins, PDR, Stidham, RW, Montain, SJ, Waljee, AK, Journal of Crohn's and Colitis, 1/1/2015
• Pushing the Pedal to the Metal: Should We Accelerate Infliximab Therapy for Patients with Severe Ulcerative Colitis?  
  Herfarth, H.H., Rogler, G., Higgins, P.D.R., Clin Gast Hepatol, 1/1/2015
• Characterization of Inflammation and Fibrosis in Crohn’s Disease Lesions by Magnetic Resonance Imaging  
  Higgins, PDR, Fletcher, JG, The American journal of Gastroenterology, 1/1/2015
• The Current State of the Inflammatory Bowel Disease Drug Pipeline: A Promising Time  
  Goldsmith, JR, Higgins, PDR, Practical Gastroenterology, 1/1/2015
• Detecting Inflammation and Fibrosis in Bowel Wall with Photoacoustic Imaging in a Crohn’s disease animal model  
  Xu, G, Johnson, LA, Hu, J, Dillman, JR, Higgins PDR, Wang, X, SPIE BiOS, 1/1/2015
• Increasing ultraviolet light exposure is associated with reduced mortality from Clostridium difficile infection  
  Govani, SM, Waljee, AK, Stidham, RW, Higgins, PDR, United European Gastroenterology Journal, 1/1/2015
• Factors Associated with Poor Outcomes in Adults with Newly Diagnosed Ulcerative Colitis  
  Reinisch, W., Renink, A.R., Higgins, P.D.R., Clinical Gastroenterology and Hepatology, 1/1/2015
• Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis  
  Sisson, TH,Ajayi, IO, Subbotina, N, Dodi, AE, Rodansky,ES, Chibucos, LN, Kim, KK, Keshamouni, VG, White, ES, Zhou, Y, Higgins, PDR, Larsen,SD, Neubig, RR, Horowitz, JC, Am J Path, 1/1/2015
• Improvement of predictive models of risk of disease progression in chronic hepatitis C by incorporating longitudinal data  
  Konerman, MA, Zhang, Y, Zhu, J., Higgins, PDR, Lok ASF, Waljee AK, Hepatology, 1/1/2015
• Intestinal Organoids: A Model of Intestinal Fibrosis for Evaluating Anti-Fibrotic Drugs  
  Rodansky, ES, Johnson, LA, Huang, S, Spence, JR, Higgins, PDR, Experimental and Molecular Pathology, 1/1/2015
• Miles to Go On the SCENIC Route: Should Chromoendoscopy Become the Standard of Care in IBD Surveillance?  
  Higgins, P.D.R., Am J Gastroenterol, 1/1/2015
• Body Fat Composition Assessment Using Analytic Morphomics Predicts Infectious Complications After Bowel Resection in Crohn's Disease  
  Stidham, RW, Waljee, AK, Day, NM, Bergmans, CL, Zahn, KM, Higgins, PDR, Wang, SC, Su, GL, Inflammatory Bowel Diseases, 1/1/2015
• European Evidence-Based Consensus: Inflammatory Bowel Disease and Malignancies  
  Annese, V., Beaugerie, L., Egan, L., Biancone, L., Bolling, C., Brandts, C., Dierickz, D., Dummer, R., Fiorino, G., Gornet, J.M., Higgins, P.D.R., Katsanos, K.H., Niss..., Journal of Crohn’s and Colitis, 1/1/2015
• A Primer on Effectiveness and Efficacy Trials  
  Singal, A.G., Higgins, P.D.R., Waljee, A.K., Clin Transl Gastroenterol, 1/1/2014
• Extraintestinal malignancies in inflammatory bowel disease: Results of the 3rd ECCO Pathogenesis Scientific Workshop (III)  
  Magro, F., Peyrin-Biroulet, L., Sokol, H., Aldeger, X., Costa, A., Higgins, P.D.R., Joyce, J.C., Kastanos, K.H., Lopez, A., Mas de Xaxars, T., Toader, E., Beaugerie, L, Journal of Crohn’s and Colitis, 1/1/2014
• A Primer on Predictive Models  
  Waljee, A.K., Higgins, P.D.R., Singal, A.G., Clin Transl Gastroenterol, 1/1/2014
• Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-beta induced fibrogenesis in human colonic myofibroblasts  
  Johnson, L.A., Rodansky, E.S., Haak, A.J., Larsen, S.D., Neubig, R.R., Higgins P.D.R., Inflammatory Bowel Diseases, 1/1/2014
• Point-Counterpoint: Are we Overtreating Patients with Mild Ulcerative Colitis?  
  Waljee, A.K., Stidham, R., Higgins, P.D.R., Vijan, S., Saini, S.D., Journal of Crohn’s and Colitis, 1/1/2014
• Systematic Review with Network Meta-Analysis: The Efficacy of Anti-Tumour Necrosis Factor-Alpha Agents for the Treatment of Ulcerative Colitis  
  Stidham, R.W., Lee, T.C., Higgins, P.D.R., Deshpande, A.R., Sussman, D.A., Singal, A.G., Elmunzer, B.J., Saini, S.D., Vijan, S., Waljee, A.K., Alimentary Pharmacology and Therapeutics, 1/1/2014
• High Altitude Journeys and Flights are Associated with An Increased Risk for Flares in Inflammatory Bowel Disease Patients  
  Vavricka, S.R., Rogler, G., Maetzler, S., Misselwitz, B., Safroneeva, E., Frei, P., Manser, C.N., Biedermann, L., Fried, M., Higgins, P.D.R., Wojtal, K.A., Schoepfer, ..., Journal of Crohn’s and Colitis, 1/1/2014
• Systematic Review with Network Meta-Analysis: The Efficacy of Anti-Tumour Necrosis Factor-Alpha Agents for the Treatment of Crohn’s Disease  
  Stidham, R.W., Lee, T.C., Higgins, P.D.R., Deshpande, A.R., Sussman, D.A., Singal, A.G., Elmunzer, B.J., Saini, S.D., Vijan, S., Waljee, A.K., Alimentary Pharmacology and Therapeutics, 1/1/2014
• Response to Feagan, et al  
  Govani, S.M., Waljee, A.K, Higgins, P.D.R., American Journal of Gastroenterology, 1/1/2014
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Books/Book Chapters

• Clinical Challenges and Complications of IBD 
  Chapter: Chapter 2: Internal fistula, Abscesses, and Strictures: Evaluation with Novel Radiographic Techniques and Clinical Management 
  Higgins, P.D.R.Editors: Regueiro, M, Swoger, J..Slack Incorporated2012
• Advanced Therapy of Inflammatory Bowel Disease 
  Chapter: Percutaneous management of intra-abdominal abscesses 
  Waljee, A.K., Stidham, R.J., and Higgins, P.D.R.Editors: Bayless and Hanauer.Edition 3rd,2011
• Advanced Therapy of Inflammatory Bowel Disease 
  Chapter: Stenosis and Strictures in Crohn’s Disease 
  Awais, D.A., and Higgins, P.D.R.Editors: Bayless and Hanauer.Edition 3rd,2011
• Handbook of Inflammatory Bowel Disease 
  Chapter: Endoscopy in IBD 
  Awais, D. and Higgins, P.D.R.Editors: Stephen J. Bickston.Wolters-Kluwer2009
• The National Organization for Rare Diseases (NORD) Guide to Rare Diseases 
  Chapter: Section 8, Chapter 2, Barrett’s Esophagus 
  Page 333 - 335Higgins, P.D.R., and Askari FLippincott2001
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Abstracts/Posters

• Rectal Bleeding Accurately Reflects Level of Mucosal Inflammation in Patients With Ulcerative Colitis
  O’Byrne, S, Keir, ME, Cabanski, CR, Zhao, R, Lu, T, Faubion, WA, Fletcher, JG, Feagan, BG, Kulkarni, P, Higgins, PDR, DeHertogh, G, VanAssche, GA, Mansfield, JC, Colom..., Digestive Disease Week, 1/1/2015
• Quantitative Visceral Fat Findings Using Analytic Morphomics Are Associated With Future Surgical Bowel Resection in Stricturing Crohn's Disease
  Stidham, RW, Ruma, JA, Enchakalody, B, Waljee, AK, Govani, SM, Higgins, PDR. Su, GL, Digestive Disease Week, 1/1/2015
• Symptom Scores Do Not Accurately Reflect Level of Mucosal Inflammation in Patients With Crohn's Disease
  O’Byrne, S, Keir, ME, Cabanski, CR, Zhao, R, Lu, T, Faubion, WA, Fletcher, JG, Feagan, BG, Kulkarni, P, Higgins, PDR, DeHertogh, G, VanAssche, GA, Mansfield, JC, Sandb..., Digestive Disease Week, 1/1/2015
• Factors Associated With the Use of Corticosteroid-Sparing Medications Among Elderly Veterans With Inflammatory Bowel Disease
  Govani, SM, Witala, WL, Stidham, RW, Saini, SD, Hou, JK, Feagins, LA, Higgins, PDR, Waljee, AK, Digestive Disease Week, 1/1/2015
• Psychometric Evaluation of the Signs and Symptoms Modules of the Ulcerative Colitis Patient-Reported Outcomes Measure (UC-Pro/SS)
  Higgins, PDR, Harding, G, Patrick, DL, Revicki, DA, Chen, WH, Globe, G, Visawatha, HN, Fitzgerald, K, Trease, S, Borie, D, Ortmeier, BG, Leidy, NK, Digestive Disease Week, 1/1/2015
• Incident Infectious and Malignant Adverse Event Risk Is Lower Using Methotrexate Compared to Thiopurines in Crohn's Disease
  Chen, DD, Waljee, AK, Govani, SM, Higgins, PDR, Stidham, RW, Digestive Disease Week, 1/1/2015
• Detecting Bowel Wall Fibrosis With Photoacoustic Imaging in an Animal Model of Crohn's Disease
  Xu, G, Johnson, LA, Hu, J, Rodansky, ES, Dillman, JR, Wang, X, Higgins, PDR, Digestive Disease Week, 1/1/2015
• Elevated Fecal Calprotectin Associates With Severe Clostridium difficile Infection in Older Adults
  Rao, K, Santhosh, K, Mogle, JA, Higgins, PDR, Young, VB, Digestive Disease Week, 1/1/2015
• Increased Matrix Stiffness Modulates microRNA Expression and Fibrogenesis in an In Vitro Model of Intestinal Fibrosis
  Johnson, LA, Rodansky, ES, Higgins, PDR, Digestive Disease Week, 1/1/2015
• Psychometric Evaluation of the Coping, Daily Life Impact, and Emotional Impact Modules of the Ulcerative Colitis Patient-Reported Outcomes (UC-Pro) Measure
  Higgins, PDR, Harding, G, Patrick, DL, Revicki, DA, Chen, WH, Globe, G, Visawatha, HN, Fitzgerald, K, Trease, S, Borie, D, Ortmeier, BG, Leidy, NK, Digestive Disease Week, 1/1/2015
• Assessing Crohn’s Disease Inflammatory Biomarker Diagnostic Accuracy Using Ileocolonoscopy or a combined Ileocolonoscopy-CTE Score in the EMBARK Study
  Faubion, W.A., Fletcher, J.G., de Villiers, W.J., Salzberg, B., Plevy, S.E., Proctor, D.D., Valentine, J.F., Feagan, B.G., Higgins, P.D.R., Harris, J.M., Luca, D., O’B..., Digestive Disease Week, 1/1/2012
• Machine Learning Algorithms Outperform Conventional Regression Models in Identifying Risk Factors for Hepatocellular Carcinoma in Patients with Cirrhosis
  Singal, A.G., Waljee, A.K., Mukherjee, A., Higgins, PDR, Zhu, Ji, Marrero, J.A., Digestive Disease Week, 1/1/2012
• A Randomized Controlled Trial of Rectal Indomethacin for the Prevention of Post-ERCP Pancreatitis
  Elmunzer, B.J., Scheiman, J.M., Lehman, G.A., Chak, A., Mosler, P., Higgins, P.D.R., Hayward, R.A., Romagnuolo, J., Elta, G.H., Sherman, S., Fogel, E.L., Digestive Disease Week, 1/1/2012
• Biologic Use is Associated with A Major Reduction in Venous Thromboembolism Events Compared to Steroid Use in an IBD Flare
  Higgins, P.D.R., Yang, M., Mulani, P., Chao, J.D., United European Gastroenterology Week, 1/1/2011
• Spironolactone Inhibits TGFb-induced Fibrogenesis in vitro but is Associated with Increased Mortality in vivo
  Johnson, L.A., Govani, S.M., Joyce, J., Higgins, P.D.R., Digestive Disease Week, 1/1/2011
• Matrix Stiffness Corresponding to Strictured Small Intestine Induces a Pro-Fibrotic Response in Human Colonic Fibroblasts
  Sauder, K.L., Johnson, L.A., Rodansky, E., Blanco, L.P., Mih, J.D., Tschumperlin, D., Higgins, P.D.R., Digestive Disease Week, 1/1/2011
• Ultrasound Elasticity Imaging Can Distinguish Intestinal Inflammation From Fibrosis in the Rat TNBS Colitis Model
  Stidham, R.W., Xu, J., Johnson, L.A., Kim, K., Rubin, J.M., Moons, D., McKenna, B.J., Higgins, P.D.R., Digestive Disease Week, 1/1/2011
• Development of Patient Reported Outcome (PRO) Instruments in ulcerative colitis and Crohn’s Disease
  Higgins, P.D.R., Bhuket, T., Cross, R., Flasar, M., Docherty, M., Isaacs, K., Rustgi, A., Wren, P.A., European Crohn’s and Colitis Organization Annual Meeting, Dublin, IRL, 1/1/2011
• Inhibition of IL-17A by Secukinumab is Ineffective for Crohn’s Disease
  Hueber, W., Sands, B.E., Vandemeulebroecke, M., Reinisch, W., Higgins, P.D.R., Wehkamp, J., Feagan, B., Yao, M., Bertolino, A.P., Travis, S, European Crohn’s and Colitis Organization Annual Meeting, Dublin, IRL, 1/1/2011
• Ultrasound Elasticity Imaging Can Differentiate Acute Intestinal Inflammation and Chronic Intestinal Fibrosis from Normal Bowel in Rat Models
  Stidham, R. W., Xu, J., Johnson, L.A., Kim, K,. Rubin, J., Moons, D., McKenna, B., Higgins, P.D.R., United European Gastroenterology Week, Barcelona, 1/1/2010
• Sheathed vs. Standard Forceps: Does it Matter for Obtaining Uncontaminated Biopsy Specimens of Microbiota From the Terminal Ileum?
  Dave, M., Johnson, L.A., Chaudhary, M.N., FunNell, J.A., Stidham, R.W., Walk, S., Young, V.B., Higgins, P.D.R., Digestive Disease Week, 1/1/2010
• Increased Matrix Stiffness Induces a Fibrogenic Phenotype in Human Colonic Mesenchymal Cells
  Blanco, L.P.., Johnson, L.A., Sauder, K.L., Reider, F., M., Fiocchi, C., Liu, F., Mih, J.D., Tschumperlin, D., Higgins, P.D.R., Digestive Disease Week, 1/1/2010
• Atorvastatin Induces Apoptosis In Vitro and Slows Growth of Tumor Xenografts but Does Not Reduce Polyp Initiation
  Huang, E., Johnson, L.A., Eaton, K.A., Hynes, M., Carpentino, J., Higgins, P.D.R., Digestive Disease Week, 1/1/2010
• A Pilot Study of Ultrasound Elasticity Imaging to Identify and Measure Segmental Intestinal Fibrosis in Patients With Crohn's Disease
  Stidham, R.W., Xu, J., Kim, K., Rubin, J.M., Moons, D., McKenna, B., Rangwalla, S., Higgins, P.D.R., Digestive Disease Week, 1/1/2010
• Proximity to disease and preferences for treatment: Physician and patient perceptions of moderate ulcerative colitis and post-colectomy states
  Brown, L., Waljee, A.K., Higgins, P.D.R. and Morris, A.M., American Society of Colorectal Surgeons, Minneapolis, MN, 1/1/2010
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Lectures

• Intestinal Fibrosis: Measurement and Development of Therapie 
  Cedars-Sinai Hospital, Los Angeles, CA - 1/11/2016
• Patient Reported Outcomes in IBD 
  Bethesda, MD - 1/30/2015
• Inflammatory Bowel Disease for the Primary Practitioner 
  1/29/2015
• Machine Learning in Gastroenterology 
  Rambam Medical Center, Haifa, Israel - 1/28/2015
• IBD Research Event: Facebook Live with the CCFA 
  1/25/2015
• Inflammatory Bowel Disease from Bench to Bedside 
  St. John's Hospital, Detroit, MI - 1/24/2015
• Monitoring IBD Activity 
  GEDIIB, Curitiba, Brazil - 1/24/2015
• Optimization of IBD Therapy 
  1/24/2015
• Treatment Optimization in IBD 
  GEDIIB, Curitiba, Brazil - 1/23/2015
• Monitoring Disease Activity in Inflammatory Bowel Disease 
  1/23/2015
• The Pipeline of New Therapies in Inflammatory Bowel Disease 
  1/22/2015
• The Pipeline of New IBD Therapies 
  GEDIIB, Curitiba, Brazil - 1/21/2015
• IBD Round Table 
  1/19/2015
• Endpoints that Patients Care About 
  1/18/2015
• Managing Iron Deficiency Anemia in IBD 
  Honolulu, HI - 1/18/2015
• Optimization of Medical Treatment of Inflammatory Bowel Disease 
  National Taiwan University College of Medicine - 1/15/2015
• Use of Immunomodulators and Biologics, When and How 
  National Taiwan University College of Medicine - 1/15/2015
• When to Assess Response to IBD Therapy in UC 
  Taipei, Taiwan - 1/14/2015
• How To Optimize Biological Therapy in UC 
  Taipei, Taiwan - 1/14/2015
• Biologics Beyond Anti-TNFs 
  Taipei, Taiwan - 1/14/2015
• Improving the Quality of IBD Care 
  1/14/2015
• When to Assess the Success of Induction of Remission with Biologic Therapy in patients with Ulcerative ColitisColitis 
  National Taiwan University College of Medicine - 1/14/2015
• How to Optimize Biologic Therapy to Maintain Remission in Patients with Ulcerative Colitis 
  National Taiwan University College of Medicine - 1/14/2015
• Quality of Care in IBD 
  Deerfield, IL - 1/13/2015
• Optimization of Medical Therapy in IBD 
  Taipei, Taiwan - 1/13/2015
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Other

• Evaluation of Disease Activity in IBD in the Office 
  Higgins, P.D.R., The Crohn’s Disease Working Group Website
  1/1/2008