MonteSWillisMDMBA, PhD, FASCP, FCAP(He/Him)

PubMed

• 507 citations
  The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
  Brian A. Clarke, Doreen Drujan, Monte S. Willis, Leon Murphy, Richard A. Corpina
  Cell Metabolism. 2007-11-07
• 236 citations
  Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair
  Jinzhu Duan, Costin M. Gherghe, Dianxin Liu, Eric D. Hamlett, Luxman Srikantha
  The EMBO Journal. 2012-01-18
• 638 citations
  MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
  Thomas E. Callis, Kumar Pandya, Hee Young Seok, Ruhang Tang, Mariko Tatsuguchi
  The Journal of Clinical Investigation. 2009-09-01

Journal Articles

• Regulation of the Ubiquitin Proteasome and Calpain Systems in a Dog Model of Duchenne Muscular Dystrophy.  
  Wadosky KM, Li L, Rodríguez JE, Min J, Bogan D, Gonzalez J, Patterson C, Kornegay JN, Willis MS, Muscle and Nerve
• Bmper inhibits endothelial inflammation and protects against atherosclerosis.  
  Pi X, Lockyer P, Dyer L, Schisler J, Carey S, Sweet DT, Chen Z, Tzima E, Willis MS, Homeister JW, Moser M, Patterson C, Arterioscler Thromb Vasc Biol
• A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting.  
  Files DC, Franco RD, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tanskersley CG, Messi ML, L..., Am J Respir Crit Care Med
• Myosin light chain phosphorylation is critical for adaptation to cardiac stress.  
  Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupine-Furlow J, McMullen JR, Moss RL, Kasahara H, Circulation
• Selective inhibition of NF-kappa-B with NBD peptide reduces tumor-induced wasting in a murine model of cancer cachexia in vivo.  
  Wysong A, Asher SA, Yin X, Gore MR, Weinstein L, Guttridge D, Baldwin A, Couch M, Willis MS, J Cancer Sci Ther
• Luminaries in Laboratory Medicine: Percy Lavon Julian Pioneer of Medicinal Chemistry Synthesis.  
  Wilson BA, Willis MS, Lab Med
• Autoimmune hepatitis type 2.  
  Willis MS, Latimer MJ, Lab Med
• Urine crystals in a 1 year old male.  
  Fender J, Willis MS, Fedoriw Y, Lab Med
• The challenges and complexities of thyroid hormone replacement.  
  Kansagra S, McCudden CM, Willis MS, Lab Med
• Luminaries in Laboratory Medicine: Sir Hans Adolf Krebs.  
  Wilson BA, Schisler JC, Willis MS, Lab Med
• Ubiquitin Drug Discovery and Diagnostics 2009.  
  Schisler JC, Willis MS, Target Intelligence Service/ Current BioData Ltd
• Luminaries in Laboratory Medicine: Ivar Asbjörn Følling.  
  Gonzalez J, Willis MS, Lab Med
• Luminaries in Laboratory Medicine: Karl Landsteiner, MD.  
  Durand JK, Willis MS, Lab Med
• Luminaries in Laboratory Medicine: Robert Guthrie.  
  Gonzalez J, Willis MS, Lab Med
• Luminaries in Laboratory Medicine: Arne Tiselius.  
  Willis MS, Lab Med
• Recent advances in the detection of prostate cancer using epigenetic markers in commonly collected laboratory samples.  
  Maxwell JA, McCudden CR, Wians F, Willis MS, Lab Med
• Toxoplasma infection: making the best use of laboratory tests.  
  Southern P, Willis MS, Infec Med (2002, 2006)
• Biomarkers for colon cancer (cover story).  
  Willis M, Fuda F, Chenault C, MLO Med Lab Obs
• Edge of the world: Practical considerations and a clinical perspective of Next-Generation Sequencing for hereditary cardiac disease.  
  Jensen BC, Willis MS, Expert Opin Med Diagn
• Luminaries in Laboratory Medicine: Konrad Bloch.  
  Pendse A, Lockyer P, Schisler J, Willis M, Lab Med
• Kids in America: Newborn screening for Cystic Fibrosis.  
  Bender L, Cotten S, Willis M, Lab Med
• Bedbugs in the 21st Century-The Reemergence of an Old Foe.  
  Williams K, Willis MS, Lab Med
• The molecular pathophysiology, differential diagnosis, and treatment of myeloperoxidase deficiency.  
  Ren R, Fedoriw Y, Willis MS, J Clin Exp Pathology
• Reducing laboratory billing defects using six sigma principles.  
  Levtzow CB, Willis MS, Lab Medicine
• Cancer cachexia’s metabolic signature in a murine model confirms a distinct entity.  
  Der-Torossian H, Asher SA, Winnike JH, Wysong A, Yin X, Willis MS, O’Connell TM, Couch ME, Metabolomics
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Books/Book Chapters

• Molecular and Translational Vascular Medicine. 
  Willis MS, Homeister JWSpringer Science, Business Media, New York, NY
• ASCP Caseset Laboratory Medicine. 
  Chapter: Transfusion Medicine Overview 
  Page 200 - 206Afenyi-Annan A, Willis MEditors: Willis MS, Wians FH.ASCP Press, Ohio
• Ubiquitylation dependent signaling in heart disease. 
  Willis MS, Portbury A, Ronnebaum S, Zungu M, Townley-Tilson D, Patterson CEditors: Willis MS, Patterson C.Springer Science+Business Media, New York, NY
• Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques. 
  Willis MS, Patterson CSpringer Science+Business Media, New York, NY
• ASCP Caseset Laboratory Medicine. 
  Willis MS and Wians FHASCP Press
• ENCYCLOPEDIA OF LIFE SCIENCES 2010. 
  Chapter: Atherosclerosis: Pathogenesis, Genetics and Experimental Models 
  Homeister, JW, Willis MSJohn Wiley & Sons, Ltd
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Method evaluation and quality management 
  Page 88 - 129McCudden CR, Rogers M, Erickson J, Erickson R, Willis MSEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 6,
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Circulating tumor markers: basic concepts and clinical applications 
  Page 637 - 650McCudden CR, Willis MSEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 6,
• Contemporary Practice in Clinical Chemistry. 
  Chapter: Hypothalamic, pituitary, and gonadal disorders 
  Page 351 - 364Grenache DG, Willis MSEditors: Clarke W, DuFour DR.AACC Press, Washington, DC
• The Molecular Basis of Human Cancer. 
  Chapter: Novel cancer therapies targeting angiogenesis 
  Willis MS, Klauber-DeMore NEditors: Coleman WB and Tsongalis GJ.Springer Science+Business Media, New York, NYEdition 2,
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Circulating Tumor Markers: Basic Concepts and Clinical Applications 
  McCudden CR, Willis MSEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 7,
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Method Evaluation 
  Henderson M, Willis MS, Cotten SW, Rogers MW, McCudden CEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 7,
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Laboratory Markers of Cardiac Damage and Function 
  Durando M, Jensen B, Willis MSEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 7,
• Clinical Chemistry: Principles, Procedures, Correlations. 
  Chapter: Lean Six Sigma Methodology for Quality Improvement in the Clinical Chemistry Laboratory 
  Cotten SW, McCudden CR, Rogers MW, Willis MSEditors: Bishop ML, Fody EP, Schoeff LE.Lippincott Williams & Wilkins, Baltimore, MDEdition 7,
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Abstracts/Posters

• STAT3 activation in cardiac hypertrophy induced by ryanodine receptor 2 mutation.
  Huang T, Lee J, Zou M, Pasek DA, Willis MS, Meissner G, American Society for Investigative Pathology, Oral presentation: Cardiac Pathobiology Minisymposium, Boston, MA
• Muscle Ring Finger-1 (MuRF1) inhibits PPARα through mono-ubiquitination of specific lysines adjacent to a novel nuclear export sequence (NES).
  Willis MS, Liao J, American Physiology Society, Boston, MA
• Knockout of the Glucocorticoid Receptor in Cardiomyocytes Leads to Spontaneous Cardiovascular Disease and Death.
  Cruz-Topete D, Oakley R, Ren R, Willis MS, Cidlowski JA, The Endocrine Society, Glucocorticoids & Glucocorticoid Actions Symposium, San Francisco, CA
• MuRF1 inhibits JNK signaling in cardiac ischemia reperfusion injury by degrading phosphorylated,
  Willis MS, Li H, Rodríguez JE, Li L, Rojas M, Lockyer P, Patterson C, FASEB J
• CHIP mono-ubiquitination activity – effects on cardiovascular metabolism and AMPK activity.
  Schisler JC, Willis MS, Patterson C, Experimental Biology, FASEB J, Anaheim, CA
• Cardiac MuRF1 expression alters mitochondrial oxidative phosphorylation function in vivo.
  Willis MS, Rodríguez JE, Zungu M, Experimental Biology, FASEB J, Anaheim, CA
• The cardiac ubiquitin ligase muscle ring finger-1 (MuRF1) ubiquitinates and degrades PPAR-alpha to regulate fatty acid and glucose metabolism.
  Rodríguez JE, Li L, Schisler JC, Patterson C, Willis MS, Circulation
• MuRF1 and MuRF2 are necessary but functionally redundant during developmental cardiac growth in vivo.
  Rodríguez JE, Li L, Patterson C, Willis MS, Circulation
• The cardiac ubiquitin ligase muscle ring finger-1 (MuRF1) regulates fatty acid and glucose metabolism through its interaction with PPAR-alpha.
  Rodríguez JE, Schisler JC, Willis MS, Seventh Annual Scientific Sessions of the Society for Heart and Vascular Metabolism meeting, Padova, Italy
• The cardiac ubiquitin ligase muscle ring finger-1 (MuRF1) inhibits creatine kinase activity in vivo.
  Willis MS, Schisler JC, Li L, Rodríguez JE, Patterson C, Seventh Annual Scientific Sessions of the Society for Heart and Vascular Metabolism meeting, Padova, Italy
• The role of muscle ring finger-1 (MuRF1) in fenofibrate-induced cardiac hypertrophy in vivo.
  Willis MS, Schisler JC, Lockyer P, Rodríguez JE, Patterson C, Seventh Annual Scientific Sessions of the Society for Heart and Vascular Metabolism meeting, Padova, Italy
• Activation of PPARα in mice lacking CHIP expression develop spontaneous cardiac hypertrophy.
  Schisler JC, Willis, MS, Lockyer P, Patterson C, Seventh Annual Scientific Sessions of the Society for Heart and Vascular Metabolism meeting, Padova, Italy
• Sildenafil ameliorates cardiomyopathy in dystrophin-null (mdx) mice.
  Parchen MC, Dai DF, Percival JM, Willis M, Froehner SC, Beavo JA, BMC Pharmacology, Regensburg, Germany
• Long-term improvement in MDX cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.
  Willis MS, Jearawiriyapaisarn N, Kole K, FASEB J
• NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.
  Willis MS, Wysong A, Rodríguez JE, Baldwin A, Couch M, FASEB J
• Transcriptional regulation of cardiomyocyte PPAR-alpha by stretch.
  Rodríguez J, Case N, Li L, Rubin J, Willis MS, FASEB J
• Spontaneous cardiac hypertrophy results from the loss of muscle ring finger 1 and 2.
  Rodríguez JE, Li L, Lockyer P, Patterson C, Willis MS, FASEB J
• CHIP directly regulates AMPK activity and its critical regulator of the cardiac stress response to metabolic challenge.
  Schisler JC, Willis MS, Kang E, Patterson C, Eighth Annual Scientific Sessions of the Society for Heart and Vascular Metabolism meeting, Kananaskis, Alberta, Canada
• Echocardiography under isoflurane anesthesia affects heart rate and function in commonly utilized mouse strains.
  Rojas M, Meredith D, Kylander J, Barrick D, Corn D, Lockyer P, Patterson C, Willis MS, FASEB J
• Cardiac muscle ring finger-1 (MuRF1) is cardioprotective in ischemia/reperfusion injury in vivo.
  Willis MS, Schisler JC, Lockyer P, McDonough, Patterson C, Marie Curie Symposium: The ubiquitin proteasome system in cardiovascular disease, Hamburg, Germany
• Muscle ring finger-1 (MuRF1) expression is essential for the reversal of cardiac hypertrophy in vivo.
  Willis MS, Rojas M, Li L, Ike C, Patterson C, Circulation
• Bmper (BMP-binding endothelial cell precursor-derived regulator) is critical to cardiac muscle mass regulation during development and pressure overload induced hypertr...
  Willis MS, Ren R, Patterson C, Circulation
• Muscle ring finger-1 (MuRF1) expression shifts cardiomyocyte substrate utilization from fatty acids to glucose.
  Willis MS, Schisler JC, McDonough H, Patterson C, Circulation
• Cardiac specific muscle ring finger-1 (MuRF1) protects against ischemia/reperfusion injury in vivo.
  Willis MS, Rojas M, Lockyer P, Meredith D, Hampton TG, Li L, Patterson C, Circulation
• Deletion of Bmper in mice identifies a novel Bmp-dependent pathway for regulating cardiomyocyte hypertrophy.
  Ren R, Willis MS, McDonough H, Kelley R, Wu Y, Patterson C, Circulation
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Lectures

• Bedbugs in the 21st century-The re-emergence of an old foe. 
  UNC
• Regulation of cardiac hypertrophy and metabolism by the ubiquitin ligase muscle ring finger-1. 
  American Society of Investigative Pathology sponsored Workshop, Anaheim, CA
• The Ubiquitin Ligase Muscle Ring Finger-1 (MuRF1) Protects Against Cardiac Ischemia Reperfusion Injury In Vivo. 
  Ubiquitin Drug Discovery and Diagnostics 2009. Philadelphia, PA
• Myocyte-Specific Regulation of Fatty Acid and Glucose Metabolism. 
  University of Texas Houston Medical School, Cardiology Research Seminar, Houston, Tex
• Regulation of Cardiac Disease and Metabolism by Muscle Ring Finger-1 (MuRF1). 
  University of Washington, Center for Cardiovascular Regenerative Biology, Seattle, Wash
• Regulation of Cardiac Hypertrophy and Metabolism by Muscle Ring Finger-1 (MuRF1). 
  Institute of Experimental and Clinical Pharmacology, Eppendorf University Hospital, Hamburg, Germany
• Muscle Ring Finger-1 (MuRF1) in Cardiac Metabolism. 
  East Carolina University, Dr. Neufer Metabolism Group
• Beyond Size Regulation: Muscle Ring Finger-1 (MuRF1) in Cardiac Physiology and Disease. 
  East Carolina University, Department of Physiology Seminar Series
• Screening for Sexually Transmitted Diseases 2010. 
  UNC
• An update on the diagnosis of Treponema pallidum. 
  UNC
• Agranulocytosis in the setting of cocaine use. 
  UNC
• A clinical and diagnostic review of Babesiosis. 
  UNC
• Transcriptional regulation of cardiac ischemia reperfusion injury and metabolism by muscle-specific ubiquitin ligases. 
  American Physiology Society Cardiovascular Section sponsored Symposium, Anaheim, CA
• Human Ehrlichiosis and Anaplasmosis. 
  UNC
• Sickle Cell Trait and Athletic Screening Programs. 
  UNC
• Microbiology, Pathogenesis, and Epidemiology of Anthrax. 
  UNC
• West Nile Virus: Epidemiology, Pathogenesis, Treatment and Prevention. 
  UNC
• Clinical utility of using absolute white blood cell counts in treating the UNC CHS population. 
  UNC
• Role of Sweat Chloride Testing in the Diagnosis and Screening for Cystic Fibrosis. 
  University of North Carolina Hospitals
• Role of Sweat Chloride Testing in the Diagnosis of Cystic Fibrosis. 
  University of North Carolina Hospitals
• Diagnosis of Cystic Fibrosis by Sweat Testing in the era of New Born Screening / Molecular Diagnosis. 
  University of North Carolina Hospitals
• Syphillus Testing Update. 
  University of North Carolina Hospitals
• Chemical Analysis of Lipids and Lipoprotein Metabolism. 
  University of North Carolina Hospitals
• The role of ubiquitin ligases in the regulation of cardiac metabolism and mitochondrial biology in cardiac disease. 
  American Heart Association Scientific Sessions 2011
• Regulation of Protein Turnover in the Heart and its Relationship to Cardiac Hypertrophy. Symposium: Mechanisms of Fetal and Neonatal Cardiac Growth. 
  Pediatric Academy of Sciences Annual Meeting. Washington, DC
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Other

• The case of the coca-cola colored urine. 
  Narayan SB, Willis MS, Baskin LB, Latimer MJ, Lab Med
• Fever and neutropenia in an adolescent with leukemia. 
  Willis MS, Cavuoti DC, Lab Med
• Confounding issues in the diagnosis of multiple sclerosis: lyme disease testing. 
  Willis MS, Bai Y, Lab Med
• Failure to thrive in a 14-month-old child. 
  Willis MS, Bennett MJ, Lab Med
• Chronic cough in an older female. 
  Sigauke E, Kamba TT, Willis MS, Lab Med
• Abdominal tenderness in a male. 
  Willis MS, Wians FH Jr, Baskin, LB, Lab Med
• Altered mental status in a middle-aged male. 
  Willis MS, Fuda FS, Burns D, Baskin LB, Lab Med
• Bone pain in a middle-age woman. 
  Willis MS, Baskin LB, Wians FH Jr, Lab Med
• The case of recurrent sinusitis. 
  Willis MS, Latimer MJ, Lab Med
• Proximal extremity weakness and altered mental status. 
  Brouse CF, Willis MS, Lab Med
• Mixed aphasia in an adult male with AIDS. 
  Willis MS, Bell ML, Najera RY, Wians FH Jr, Lab Med
• Acute diarrhea in a young traveler. 
  Willis MS, So SG, Lab Med
• The case of the needle-shaped crystals. 
  Willis MS, Baskin LB, Lab Med
• Marked proteinuria in a young male. 
  Willis MS, Wians FH, Lab Med
• Chronic myelogenous leukemia. 
  Willis MS, Wilson KS, Lab Med
• Primary amoebic meningoencephalitis. 
  Fuda F, Sigauke E, Cavuoti D, Gander R, Kroft S, Willis M, Lab Med
• Nocardia meningitis. 
  Willis M, Gander R, Cavuoti D, Lab Med
• Multiple positive sweat chloride tests in an infant asymptomatic for cystic fibrosis. 
  Cotten S, Bender L, Willis MS, Lab Med
  http://www.medscape.com/viewarticle/758468
• Nasal discharge in a 50-year-old woman. 
  Chamberlain W, White MD, Wians FH, Willis MS, Lab Med
• Periumbilical rash in an immunosuppressed patient. 
  White MD, Willis MS, Fuda FS, Gander RM, Southern PM, Lab Med
• Refeeding syndrome in a severely malnourished child. 
  Willis TM, Boswell R, Willis MS, Lab Med
  http://www.medscape.com/viewarticle/489090
• Aortic valve insufficiency in a 45-year-old male. 
  Willis MS, Roth M, Gilligan P, Lab Med
  http://www.medscape.com/viewarticle/507228
• Neck pain and rash in an 18-year-old student. 
  Willis MS, Roth M, Gilligan P, Lab Med
  http://www.medscape.com/viewarticle/509096
• Recurrent nephrolithiasis in a 9-year-old female. 
  Willis MS, Lab Med
  http://www.medscape.com/viewarticle/545525
• Hepatosplenomegaly in an 8-month-old child. 
  Willis MS, Basinger AA, Fan Z, Pendyal S, Muenzer J, Hammett-Stabler C, Lab Med
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