MichaelG.HughesJr.MD

General Surgery • Louisville, KY

Pancreas, Minimally Invasive Surgery

Owner - Vanguard Surgical LLC

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Office
2401 Terra Crossing Blvd.
Suite 375
Louisville, KY 40245
Phone+1 502-912-8300

Fax+1 502-912-8310

Summary

Dr. Michael Hughes is a general surgeon in Louisville, KY that specializes in the management of gastroparesis and other foregut diseases. He received his undergraduate and medical degrees from Wake Forest University. He completed his general surgery training at the University of Virginia and transplant surgery training at the University of Minnesota.

Dr. Hughes joined the University of Louisville as Director of Pancreas Transplantation in 2010. He started and became Director of the Total Pancreatectomy-Islet Autotransplant Program in 2015 with nearly $1 million from the Jewish Heritage Fund for Excellence. To better manage his diabetic transplant patients with gastroparesis, he started placing Enterra gastric stimulators. Through collaboration with gastroenterologist Dr. Thomas Abell, MD, he expanded Enterra therapy to non-transplant patients and rapidly became the most experienced gastroparesis surgeon world-wide.

Dr. Hughes founded Vanguard Surgical to focus on the medical and surgical management of gastroparesis and chronic pancreatitis patients. He has placed more gastric stimulators than any surgeon world-wide (more than 2,000) and has performed more than 1,500 pyloroplasties for gastroparesis. He performs both as laparoscopic, outpatient procedures. With both gastric stimulation and pyloroplasty as options, surgical jejunostomy feeding tubes are rarely necessary.

Patient travel from across the United States to seek care with Dr. Hughes, centrally located in Louisville, KY and New Albany, IN.

SURGERY VIDEO: Laparoscopic Pyloroplasty for Severely Thickened Pylorus

This is a full-length, unedited video of a laparoscopic pyloroplasty performed and narrated by Dr. Michael Hughes. It runs at 2x speed for 21 minutes.

SURGERY VIDEO: Laparoscopic Gastric Stimulator Placement

This is a video of Dr. Hughes performing laparoscopic gastric stimulator placement for gastroparesis. It has been edited down to about 5 minutes.

SURGERY VIDEO: Laparoscopic Pyloroplasty

This is a video of Dr. Hughes performing laparoscopic pyloroplasty for gastroparesis. It has been edited down to about 5 minutes.

Clinical Expertise

Upper GI Endoscopy, Pyloroplasty, Transplant surgery, Autologous islet cell transplantation, Pancreatic surgery, Pancreatectomy, Renal transplant surgery, Hepatopancreatobiliary surgery, Pancreatic and islet cell transplant surgery, Gastric electric stimulation

Education & Training

University of MinnesotaFellowship, Abdominal Transplant Surgery, 2006 - 2008
University of Virginia Medical CenterResidency, Surgery, 1999 - 2006
Wake Forest School of Medicine of Wake Forest Baptist Medical CenterClass of 1999
Wake Forest UniversityB.A., English, 1989 - 1993

Work Experience

Vanguard Surgical - General SurgerySurgeon · May 2019 - Current
UofL Health - Jewish Hospital (Louisville, KY)Director Of Pancreas And Islet Transplantation · October 2010 - April 2019
Medical University of South CarolinaAssistant Professor Of Surgery · August 2008 - September 2010

Certifications & Licensure

IN State Medical License 2020 - 2025
KY State Medical License 2011 - 2025
SC State Medical License 2008 - 2011
MN State Medical License 2006 - 2009
VA State Medical License 1999 - 2006
American Board of Surgery Surgery
American Society of Transplant SurgeonsLiver, Kidney and Pancreas Transplantation

Awards, Honors, & Recognition

Young Investigator’s Award International Gastrointestinal Electrophysiology Society, 2015
Healthcare Innovation Award, Islet Auto-transplantation Program MediStar, 2015
Poster of Distinction Award American Transplant Congress, 2013
Career Development Award in Liver Transplantation American Association for the Study of Liver Diseases, 2013
Team Donate Life Junior Faculty Award American Society of Transplant Surgeons, 2009
Nominated for Consultant of the Year Award 2004
Pfizer Award for Scholastic Achievement 2004
Medicine Surgical Specialty Award Society of Critical Care, 2002
Surgical Resident Research Day Award University of Virginia, 2002
Surgical Sciences Scholarship American Society of Transplant Surgeons-Roche, 2002
Richard L. Burt Research Achievement Award 1999
Research Scholarship American Heart Association, 1998
Research Award Association for Academic Surgery, 1998
Research Fellowship Award Lifeline Foundation, 1998
Alpha Omega Alpha, selected as a Junior Wake Forest University School of Medicine, 1997
Medical Student Research Fellowship Award National Institute of Health, 1995
Associate Fellow American College of Surgeons
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Publications & Presentations

PubMed

2 citations
Nutritional Assessment in Patients after Gastric Electrical Stimulation (GES).
Tanureet Kochar, Wenjing Cai, John J Guardiola, Prateek Mathur, Hamza Hassan
Journal of Clinical Gastroenterology. 2024-02-01
3 citations
Baseline predictive factors for foregut and hindgut response to long-term gastric electrical stimulation using augmented energy.
Mohamed Elmasry, Hamza Hassan, Prateek Mathur, Abigail Stocker, Hadi Atassi
Neurogastroenterology and Motility. 2021-10-26
16 citations
Pathophysiology of Gastroparesis Syndromes Includes Anatomic and Physiologic Abnormalities
Thomas L. Abell, Archana Kedar, Abigail Stocker, Karen Beatty, Lindsay McElmurray
Digestive Diseases and Sciences. 2021-04-01

Journal Articles

Improved Recovery of Human Islets from Young Donor Pancreases Utilizing Increased Protease Dose to Collagenase for Digesting Peri‐Islet Extracellular Matrix
Michael Hughes Jr., MD, American journal of transplantation
The impact of recipient obesity on outcomes after renal transplantation
Cannon RM, Jones CM, Hughes MG, Eng M, Marvin MR, Annals of Surgery, 1/1/2013
A review of the United States experience with combined heart-liver transplantation
Cannon RM, Hughes MG, Jones, CM, Eng, M, Marvin MR, Transplant International, 1/1/2012
BK virus in renal transplantation
Cannon R, Ouseph R, Jones C, Hughes M, Eng M, Marvin M, Current Opinion in Organ Transplantation, 1/1/2011
Long-term outcome in 42 pediatric liver transplant patients with alpha 1-antitrypsin deficiency: A single-center experience
Hughes MG, Khan KM. Gruessner AC, Sharp H, Hill M, Jie T, Kandaswamy R, Humar A, Payne WD, Gruessner RW, Clinical Transplantation, 1/1/2011
Can preemptive cytomegalovirus monitoring be as effective as universal prophylaxis when implemented as the standard of care in patients at moderate risk?
McGillicuddy JW, Weimert NA, Taber DJ, Turner A, Mitchell LA, Wray DW, Egidi MF, Kuppachi S, Hughes MG, Baliga PK, Chavin KD, Transplantation, 1/1/2010
Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity
Zhang Y, Liu Y, Moxley KM, Golden-Mason L, Hughes MG, Liu T, Heemskerk MHM, Rosen HR, Nichimura MI, PLoS pathogens, 1/1/2010
Human liver transplantation as a model to study HCV pathogenesis
Hughes MG, Rosen HR, Liver Transplantation, 1/1/2009
Graft weight/recipient weight ratio: How well does it predict outcome after partial liver transplants?
Hill MJ, Hughes MG, Jie T, Cohen M, Lake J, Payne WD, Humar A, Liver Transplantation, 1/1/2009
Does body mass index affect infection-related outcomes in the intensive care unit?
Smith RL, Chong TW, Hedrick TL, Hughes MG, Evans HL, McElearney ST, Pruett Tl, Sawyer RG, Surg Infect (Larchmt), 1/1/2007
Cost of gram-negative resistance
Evans HL, Lefrak SN, Lyman J, Smith RL, Chong TW, McElearney ST, Schulman AR, Hughes MG, Raymond DP, Pruett TL, Sawyer RG, Crit Care Med, 1/1/2007
General surgery morning report: A competency-based conference that enhances patient care and resident education
Stiles BM, Reece TB, Hedrick TL, Garwood RA, Hughes MG, Dubose JJ, Adams RB, Schirmer BD, Sanfey HA, Sawyer RG, Curr Surg, 1/1/2006
Primary human hepatocytes in spheroid formation to study hepatitis C infection
Chong TW, Smith RL, Hughes MG, Camden J, Rudy CK, Evans HL, Sawyer RG, Pruett TL, J Surg Res, 1/1/2006
Comparison of fungal and nonfungal infections in a broad-based surgical patient population
Hughes MG, Chong TW, Smith RL, Evans HL, Pruett TL, Sawyer RG, Surg Infect (Larchmt), 1/1/2005
Nature of gram-negative rod antibiotic resistance during antibiotic rotation
Evans HL, Milburn ML, Hughes MG, Smith RL, Chong TW, Raymond DP, Pelletier SJ, Pruett TL, Sawyer RG, Surg Infect (Larchmt), 1/1/2005
HCV infection of the transplanted liver: Changing CD81 and HVR1 variants immediately after liver transplantation
Hughes MG, Chong TW, Smith RL, Evans HL, Iezzoni JC, Sawyer RG, Rudy CK, Pruett TL, Am J Transplant, 1/1/2005
Impact of immunomodulatory oligodeoxynucleotides on cytokine production in the lipopolysaccharide-stimulated human whole blood model
Smith RL, Chong TW, Hughes MG, Hedrick TL, Evans HL, MacElerney ST, Salwaacher AR, Raymond DP, Du K, Rudy CK, Pruett TL, Sawyer RG, Surgery, 1/1/2004
E2 quasispecies specificity of hepatitis C versus association with allografts immediately after liver transplantation
Hughes MG, Rudy CK, Chong TW, Smith RL, Evans HL, Iezzoni JC, Sawyer RG, Pruett TL, Liver Transplantation, 1/1/2004
Effect of an ICU rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit ward
Hughes MG, Raymond DP, Evans HL, Smith RL, Chong TW, Pruett TL, Sawyer RG, Crit Care Med, 1/1/2004
Does prior transfusion worsen outcomes from infection in surgical patients?
Hughes MG, Evans HL, Lightfoot L, Chong TW, Smith RL, Raymond DP, Pelletier SJ, Claridge JA, Pruett TL, Sawyer RG, Surgical Infections, 1/1/2003
Contact isolation in surgical patients: A barrier to care?
Evans HL, Shaffer MM, Hughes MG, Smith RL, Chong TW, Raymond DP, Volles DF, Pelletier SJ, Pruett TL, Sawyer RG, Surgery, 1/1/2003
Fungal infections in trauma and burn patients
Hughes MG, Sawyer RS, Current Treatment Options in Infectious Diseases, 1/1/2001
Hyaluronan enhances contraction of collagen by smooth muscle cells and adventitial fibroblasts Role of CD44 and implications for constrictive remodeling
Travis JA, Hughes MG, Wong JM, Wagner WD, Geary RL, Circ Res, 1/1/2001
Hyaluronan is induced by arterial injury and promotes CD44-mediated smooth muscle cell contraction of collagen gels: Potential role in restenosis
Wong JM, Hughes MG, Wagner WD, Geary RL, Cardiovasc Surg, 1/1/2000
Hyaluronan is induced by arterial injury and promotes collagen gel contraction by smooth muscle cells (SMC) and adventitial fibroblasts: Potential role in post-angiopl...
Hughes MG, Wong JA, Gotow L. Wagner WD, Geary RL, J Vasc Surg, 1/1/1999
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Books/Book Chapters

Contemporary Pancreas Transplantation
Chapter: Islet cell transplantation in organ and tissue transplantation.
Balamurugan AN, Loganathan G, Tweed B, Hughes MG, Williams SKEditors: Lim JW.Springer International Publishing2016

Abstracts/Posters

Rate of hepatitis C viral clearance by human livers in human patients: Liver transplantation modeling primary infection and implications for studying entry inhibition.
Hughes MG Jr, Tucker WW, Reddy S, Brier ME, Koch D, McClain CJ, et al, PLOS One, 1/1/2017
Mechanisms of Angiogenesis Process after Pancreatic Islet Cell Transplantation: Role of Intra-islet Endothelial Cells.
Narayanan S, Loganathan G, Dhanasekaran M, Hughes MJ, Williams SK, et al, J Transplant Technol Res, 1/1/2017
Technical Modifications to Improve Islet Yield from Chronic Pancreatitis Pancreas (CPP) for Islet Auto-Transplantation (IAT).
Dhanasekaran M, Loganathan G, Narayanan S, Tucker W, Patel A, et al, J Clin Exp Transplant, 1/1/2017
(Tul427) Neuromuscular evaluation of drug and device refractory patients with the symptoms of gastroparesis reveals a variety of adnormalities.
Abell TL, Soota K, Patel C, McElmurray L, Stocker AM, Hughes MG, Kedar A, Vendanarayanan V, Rashed H, Gastroenterology, 1/1/2015
Multicenter experience with Simeprevir/Sofosbuvir combination therapy for recurrent Hepatitis C virus infection in liver transplant recipients from all centers within ...
Crittenden N, Buchanan L, Rosenau J, Marsano L, Goshko B, McClain C, Barve A, Marvin M, Jones C, Davis EG, Hughes M, Cave M, AASLD Conference, 1/1/2015
(Sul851) Clinical correspondence of S100 levels on full thickness gastric biopsy.
Patel C, Abell TL, Soota K, Yang X, Faig MM, Beatty K, Miller E, Kedar A, Hughes MG, McElmurray L, Stocker AM, Kennedy WR, Wendelschafer-Crabb G, Gastroenterology, 1/1/2015
(Sul864) Clinical correspondence of interstitial cells of cajal values from full thickness gastric biopsy in patients undergoing gastric stimulation for diabetic gastr...
Patel C, Soota K, Yang X, El Jamal SM, Fraig MM, Beatty K, Miller E, Kedar A, Hughes MG, McElmurray L, Stocker AM, Abell TL, Gastroenterology, 1/1/2015
(Sul420) Evaluating gastric mucosal nerve density in relation to full thickness biopsy, gastric emptying, symptoms and response to temporary gastric stimulation.
Patel C, Yang X, Wendelschafer-Crabb G, Kennedy WR, Beatty K, Miller E, Kedar A, Hughes MG, McElmurray L, Fraig MM, Stocker AM, Abell TL, Gastroenterology, 1/1/2015
(Tul963) Gastric electrical stimulation is effective in reducing symptoms of malignancy associated gastroparesis.
Shah H, Wendorf G, Ahmed S, McElmurray L, Hughes MG, Miller E, Stocker AM, Abell TL, Gastroenterology, 1/1/2015
(Sul422) Autonomic and enteric responses to temporary gastric electrical stimulation.
Vermani S, Patel AA, Miller E, Beatty K, Stocker AM, Hughes MG, Rashed H, Kedar A, Abell TL, Gastroenterology, 1/1/2015
Initiation and early results of an Alemtuzumab-induction program utilizing a Belatacept in kidney transplantation.
Marvin MR, Eng M, Ouseph R, Jones CM, Davis E, Hughes M, American Journal of Transplantation, 1/1/2014
Next generation sequencing of the hepatitis C virus transmitted during liver transplantation reveals selection within hypervariable region1.
Hughes MG, Rouchka EC, Marvin MR, McClain CJ, Jonsson CB, American Journal of Transplantation, 1/1/2014
Single center experience with Simeprevir/ Sofosbuvir combination therapy for recurrent hepatitis C virus infection in liver transplant recipients.
Marsano LS, McClain CJ, Barve A, Goshko BA, Tatum RR, Cave MC, Crittenden N, Davis EG, Hughes MG, Jones CM, Marvin MR, American Association for the Study of Liver Diseases, 1/1/2014
Is micro-RNA-122 (miR-122) an accurate biomarker for ischemia-reperfusion injury during liver transplantation?
Hughes MG, Reddy SC, Brier M, McClain CJ, Jonsson CB, American Journal of Transplantation, 1/1/2013
The presence of polyomavirus BK replication in urine or plasma correlate with significant renal impairment in renal transplant recipients.
Eng M, Jones CM, Hughes MG, Davis E, Marvin MR, American Journal of Transplantation, 1/1/2013
Characterization of the variability in uptake of Hepatitis C virus (HCV) by liver allografts during reperfusion.
Hughes MG, Reddy S, Brier M, Marvin MR, Jones CM, Eng M, Jonsson C, American Journal of Transplantation, 1/1/2012
Combined heart-liver transplantation in the United States.
Cannon RM, Hughes MG, Jones CM, Eng M, Marvin MR, Journal for Surgical Research, 1/1/2012
Impact of MicroRNA-122 (miR-122) and small RNA prdocution on Hepatitis C Viral (HCV) uptake by liver allografts during reperfusion.
Hughes MG, Reddy SC, Brier M, McClain C, Jonsson CB, Hepatology, 1/1/2012
Evolution of cytomegalovirus (CMV) and BK virus complications after kidney transplantation with Alemtuzumab induction.
Hughes MG, Cannon RM, Ouseph R, Mackelaite L, Eng M, Jones CM, Marvin MR, American Journal of Transplantation, 1/1/2012
Does BMI affect infection-related outcomes in the ICU?
Smith RL, Chong TW, Hedrick TL, McElearney ST, Hughes MG, Evans HL, Sawyer RG, Pruett TL, Surg Infect, 1/1/2006
Recapture of favorable infection rates with reintroduction of quarterly two-drug antibiotic rotation against gram-negative organisms.
McElearney ST, Evans HL, Smith RL, Saalwachter AR, Chong TW, Hughes MG, Raymond DP, Pruett TL, Sawyer RG, Surg Infect, 1/1/2004
Sex hormones and infectious outcomes in surgical patients.
Evans HL, Saalwachter AR, McElearney ST, Smith RL, Chong TW, Hughes MG, Raymond DP, Pruett TL, Sawyer RG, Surg Infect, 1/1/2004
The cost of gram negative resistance.
Evans HL, Lafrak SN, Lyman J, Smith RL, Chong TW. McElearney ST, Saalwachter AR, Hughes MG, Raymond DP, Pruett TL, Sawyer RG, Crit Care Med, 1/1/2004
Nature of GNR antibiotic resistance in antibiotic rotation.
Evans HL, Milburn ML, Hughes MG, Smith RL, Chong TW, Raymond DP, Pelletier SJ, Pruett TL, Sawyer RG, Surg Infections, 1/1/2003
Quarterly Vancomycin/Linezolid reduced resistant gram-positive infections in an Intensive Care Unit.
Smith RS, Evans HL, Chong TW, Hughes MG, Raymond DP, Pelletier EJ, Popovsky K, Bledsoe K, Volles D, Scheld M, Pruett TL, Sawyer RG, 41st Meeting of IDSA Meeting Program, 1/1/2003
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Lectures

The Natural History of Diabetes 3c and the Importance of Maintaining C-peptide Positivity after Total Pancreatectomy.
Chicago, IL - 1/30/2017
Peripancreatic fat-derived stromal vascular fraction cells stimulate intra-islet endothelial cells to form peri-islet vessels in human islets.
Oxford, England - 1/22/2017
Peri-islet vessels formation around human islets by stimulating intra-islet endothelial cells: Bioengineering approaches to improve islet survival after transplantation.
Oxford, England - 1/22/2017
Bio-printed spheroids with human islets and adipose-derived stromal vascular fraction cells (SVF) using a 3D bio-printing technology for improving islet integrity and ...
Oxford, England - 1/22/2017
Identifying optimal enzyme blend of collagenase and protease for obtaining high islet yield from young donor pancreases.
Oxford, England - 1/21/2017
Low cost, collagenase-protease enzyme mixtures successfully used for isolating human islets from human research pancreata.
Oxford, England - 1/21/2017
Beneficial effect of recombinant collagenases class I (rC1) and class II (rC2) on human islet function: Efficacy of low dose enzymes on pancreas digestion and yield.
Oxford, England - 1/21/2017
Total Pancreatectomy with Islet Auto-Transplantation for Chronic Pancreatitis.
Indiana University School of Medicine, Indianapolis, IN, 2016; Bowling Green, KY, 2017 - 1/16/2017
Bioengineering Human Islets to Form Peri-Islet Vessels from Intraislet Endothelial Cells for Improving Human Islet Function.
Chicago, IL - 1/2/2017
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
Chicago, IL - 1/1/2017
Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.
Chicago, IL - 1/1/2017
Islet Auto-Transplantation
Bethesda, MD - 1/25/2016
Transplant Surgery Research
1/19/2016
Peripancreatic fat-derived stromal vascular fraction (PPSVF) cells stimulate intra-islet endothelial cells to form peri-islet vessels (PIVs) in human islets.
Louisville, KY - 1/11/2016
Improved islet isolation techniques yielded high islet mass even from severely fibrotic chronic pancreatitis pancreases (CPP) intended for clinical islet autotransplan...
Louisville, KY - 1/11/2016
Identifying the effect of collagenase and protease enzyme blends on human pancreas digestion for improving islet yield and function.
Louisville, KY - 1/11/2016
Islet auto-transplantation at the University of Louisville.
University of Louisville, Louisville, KY, 2015; Louisville, KY, 2015; Washington, DC, 2016 - 1/9/2016
Neuromuscular evaluation of drug and device refractory patients with the symptoms of gastroparesis reveals a variety of abnormalities.
Washington, DC - 1/16/2015
(Sul 422) Autonomic and enteric responses to temporary gastric electrical stimulation.
Washington, DC - 1/16/2015
Gastric electrical stimulation is erffective in reducing symptoms of malignancy associated gastroparesis.
Washington, DC - 1/16/2015
Correlation of mucosal nerve density with gastric electrical activity at baseline and after gastric stimulation in patients with gastroparesis.
Washington, DC - 1/16/2015
Autonomic and enteric responses to temporary gastric electrical stimulation.
Washington, DC - 1/16/2015
(Tul 963) Gastric electrical stimulation is effective in reducing symptoms of malignancy associated gastroparesis.
Washington, DC - 1/16/2015
(Sul 420) Evaluating gastric mucosal nerve density in relation to full thickness biopsy, gastric emptying, symptoms and response to temporary gastric stimulation.
Washington, DC - 1/16/2015
(Sul 851) Clinical correspondence of S100 levels on full thickness gastric biopsy.
Washington, DC - 1/16/2015
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