MichaelW.BeckerMDCell Therapy

PubMed

• Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis.
  Kevin Lee, Wimeth Dissanayake, Melissa MacLiesh, Cih-Li Hong, Zi Yin
  Scientific Reports. 2024-09-03
• The Lactate Receptor GPR81 is a Mechanism of Leukemia-Associated Macrophage Polarization in the Bone Marrow Microenvironment.
  Celia A Soto, Maggie L Lesch, Jennifer L Becker, Azmeer Sharipol, Amal Khan
  Biorxiv. 2024-08-16
• Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.
  Benjamin J Rodems, Sonali Sharma, Cameron D Baker, Christina M Kaszuba, Takashi Ito
  Biorxiv. 2024-05-14

Journal Articles

• Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myeloid leukemia  
  Guzman ML, Yang N, Sharma KK, Balys M, Corbett CA, Jordan CT, Becker MW, Steidl U, Abdel-Wahab O, Levine RL, Marcucci G, Roboz GJ, Hassane DC, Mol Cancer Ther, 1/1/2014
• SWOG S0910: a phase 2 trial of clofarabine/cytarabine/epratuzumab for relapsed/refractory acute lymphocytic leukaemia  
  Advani AS, McDonough S, Coutre S, Wood B, Radich J, Mims M, O'Donnell M, Elkins S, Becker M, Othus M, Appelbaum FR, Br J Haematol, 1/1/2014
• Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells  
  Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes..., J Biol Chem, 1/22/2013
• A phase I study of decitabine and rapamycin in relapsed/refractory AML  
  Liesveld JL, O'Dwyer K, Walker A, Becker MW, Ifthikharuddin JJ, Mulford D, Chen R, Bechelli J, Rosell K, Minhajuddin M, Jordan CT, Phillips GL 2nd, Leuk Res, 1/1/2013
• A phase 1 trial of eltrombopag in patients undergoing stem cell transplantation after total body irradiation  
  Liesveld JL, Phillips GL 2nd, Becker M, Constine LS, Friedberg J, Andolina JR, Milner LA, Debolt J, Smudzin T, Hyrien O, Erickson-Miller CL, Johnson BM, Dawson KL, Che..., Biol Blood Marrow Transplant, 1/1/2013
• Defining patient-specific risk in acute myeloid leukemia  
  Ho TC, Becker MW, J Clin Oncol, 1/1/2013
• The hematopoietic cell transplantation specific comorbidity index and survival after extracorporeal photopheresis, pentostatin, and reduced dose total body irradiation...  
  Hashmi S, Oliva JL, Liesveld JL, Phillips GL 2nd, Milner L, Becker MW, Leuk Res, 1/1/2013
• Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity  
  Sen S, Hassane DC, Corbett C, Becker MW, Jordan CT, Guzman ML, Exp Hematol, 1/1/2013
• Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury  
  Porter R.L., M. Georger, O. Bromberg, K.E. McGrath, B.J. Frisch, M. W. Becker and L. M. Calvi, Stem Cells, 1/21/2012
• Late Relapses following High-Dose Autologous Stem Cell Transplantation (HD-ASCT) for Hodgkin's Lymphoma (HL) in the ABVD Therapeutic Era  
  Keller SF, Kelly JL, Sensenig E, Andreozzi J, Oliva J, Rich L, Constine L, Becker M, Phillips G, Liesveld J, Fisher RI, Bernstein SH, Friedberg JW, Biol Blood Marrow Transplant, 1/1/2012
• Leukemia Stemness Signatures Step toward the Clinic  
  Becker, MW and Jordan, C.T., Cell Stem Cell, 1/1/2011
• Is consolidation chemotherapy necessary before non-myeloablative transplantation in AML?  
  Hashmi S, Becker M, Leuk Res, 1/1/2011
• Reviews: The Leukemia stem cells in 2010: current understanding and future directions  
  Becker, M.W. and Jordan, C.T., Blood Rev, 1/1/2011
• Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia  
  Frisch B.J., John M. Ashton J.M., Xing L.P., Becker M.W., Jordan C.T. and L. M. Calvi, Blood, 1/1/2011
• Intra-arterial methylprednisolone for the management of steroid-refractory acute gastrointestinal and hepatic graft versus host disease  
  Milner LA, Becker MW, Bernstein SH, Bruckner L, Friedberg JW, Holland GA, Ifthikharuddin JJ, Liesveld JL, Mathes EJ, Menchel HL, Mullen CA, Sasson T, Phillips GL 2nd, Am J Hematol, 1/1/2011
• A Phase I trial of dose escalation of Melphalan in the "BEAM" regimen using Amifostine cytoprotection  
  Phillips, G.L., Bernstein, S.H., Liesveld, J.L., Abboud, C.N., Becker, M.W., Constine, L.S., Ifthikharuddin, J.J., Loughner, J.E., Milner, L.A., Vesole, D.H., Friedber..., Biol Blood Marrow Transplant, 1/1/2011
• An evolutionarily conserved PTEN-C/EBP{ALPHA}-CTNNA1 axis controls myeloid development and transformation  
  Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, ..., Blood, 1/6/2010
• Dysregulated gene expression networks in human acute myelogenous leukemia stem cells  
  Majeti R, Becker MW, Tian Q, Lee TL, Yan X, Liu R, Chiang JH, Hood L, Clarke MF, Weissman IL, Proc Natl Acad Sci USA, 1/1/2009
• Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (G...  
  Walker, A.R., Komrokji, R.S., Ifthikharuddin, J., Messina P, Mulford D, Becker M, Friedberg J, Oliva J, Phillips G, Liesveld JL, Abboud C., Leuk Res, 1/1/2008
• An orally bioavailable parthenolide analog selectively eradicates acutemyelogenous leukemia stem and progenitor cells  
  Guzman, M.L., Rossi, R.M., Neelakantan S., Li, X., Corbett, C.A., Hassane, D.C., Becker, M.W., Bennett, J.M., Sullivan, E., Lachowicz, J.L., Vaughan, A., Sweeney, C.J...., Blood, 1/1/2007
• Chromosome 5q deletionand epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation  
  Liu, T.X., Becker, M.W., Jelinek, J., Wu, W.S., Deng, M., Mikhalkevich, N., Hsu, K., Bloomfield, C.D., Stone, R.M., DeAngelo, D.J., Galinsky, I.A., Issa, J.P., Clarke,..., Nat Med, 1/1/2007
• Pilot Trial on the Use of Etanercept and Methylprednisolone as Primary Treatment for Acute Graft-versus-Host Disease  
  Uberti JP, Ayash L, Ratanatharathorn V, Silver S, Reynolds C, Becker M, Reddy P, Cooke KR, Yanik G, Whitfield J, Jones D, Hutchinson R, Braun T, Ferrara JL, Levine JE, Biol Blood Marrow Transplant, 1/1/2005
• Therapeutic implications of cancer stem cells  
  Al-Hajj M., Becker M.W., Wicha M., Weissman I., Clarke M.F., Current Opinion in Genetics & Development, 1/1/2004
• Treatment of chronic graft-versus-host disease with anti-Cd20 chimeric monoclonal antibody  
  Ratanatharathorn, V., Ayash, L., Reynolds, C., Silver, S., Reddy, P., Becker, M.W., Ferrara, J.l., Uberti, J.P., Biol Blood Marrow Transplant, 1/1/2003
• Bmi1 is required for adult hematopoietic stem cell self renewal  
  Park, I, Qian, D., Kiel, M, Becker, M.W., Pihalja, M., Weissman, IL, Morrison, I.L. and Clarke, M.F., Nature, 1/1/2003
• Join now to see all

Books/Book Chapters

• Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology 
  Chapter: Leukemic and lymphoid stem cells. 
  Becker, M.W. and O'Dwyer, K.M.Springer Health, London2015

Abstracts/Posters

• Increased Early Mortality after Fludarabine and Melphalan Conditioning with Peripheral Blood Grafts in Haploidentical SCT with Post-Transplant Cyclophosphamide
  Michael W. Becker, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic ...
  Michael W. Becker, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Microenvironmental Contribution to Dysfunctional Hematopoiesis in a Murine Model of Myelodysplastic Syndrome.
  Balderman, S. R., Frisch, B.J., LaMere, M.W., Goodman, A.N.., Becker, M.W. and Calvi, L.M., American Society of Hematology Annual Meeting, 1/1/2014
• Modulation of Interaction of Human Osteoprogenitor Cells with Hematopoietic Stem and Progenitor Cells.
  Akwaa, F., Rubinova, R., Frisch, B.J., LaMere, M.W., O'Dwyer, K.M., Liesveld, J.L. Becker, M.W. and Calvi, L.M., American Society of Hematology Annual Meeting, 1/1/2014
• Late Relapses Following High Dose Chemotherapy and Autologous Stem Cell Transplant in Patients with Diffuse Large B Cell Lymphoma in the Rituximab Era.
  Carla Casulo, C., Bradley, H.D., Herr, M.H., Barlaskar, F., Evans, A., Burack, R., Liesveld, J.L., Becker, M.W., Milner, L.A., Barr, P.M., Friedberg, J.W., American Society of Hematology Annual Meeting, 1/1/2014
• Administration of High Dose BEAM Chemotherapy As Conditioning for Autologous Stem Cell Transplantation for Lymphoma Results in Fewer Infectious Complications and Impro...
  Reid, R.M., Baran, A., Barr, P.M., Becker, M.W., Bernstein, S.H., Friedberg, J.W., Liesveld, J.L., Phillips, G.W., Wedow, L., Milner, L.A., American Society of Hematology Annual Meeting, 1/1/2014
• The Significance of GADD45A Promoter DNA Hypermethylation in AML: Association with IDH1/2 and TET2 Mutation.
  Perugini, M. Samaraweera, S.E., Brown, A.L, Cummings, N., Danner, S., Tiong, I.S., Garrett-Bakelman, F.E., Carroll, M.P., Becker, M.W., Chung, S.S, Park, C.Y., Mason, ..., American Society of Hematology Annual Meeting, 1/1/2014
• Clinical and Biologic Effects Of The Angiopoietin 1/2 Neutralizing Peptibody, Trebananib (AMG 386), In Acute Myeloid Leukemia Patients.
  Wang, E.S., Fetterly, G., Brady, W., Tan, W., Greene, J., Gaudy, A., Vigil, C.E., Mendler, J.M., Becker, M.W., O'Dwyer, K.M., Liesveld, J.L., Wetzler, M., American Society of Hematology Annual Meeting, 1/1/2014
• Disruption Of The Hematopoietic Stem and Progenitor Cell Pool and Bone Marrow Microenvironment In a Murine Model Of Myelodysplastic Syndrome.
  Balderman, S. R., Frisch, B.J., LaMere, M.W., Goodman, A.N.., Becker, M.W. and Calvi, L.M., American Society of Hematology Annual Meeting, 1/1/2014
• Epigenetic Deregulation In Relapsed Acute Myeloid Leukemia.
  Garrett-Bakelman, FE., Li, S., Hricik, T., Chung, S., Bar, H., Brown, A.L., Patel, J.P., Rapoport, F., Liu, L., Sheridan, C., Ishii, J., Zumbo, P., Gandara, J., Lewis,..., American Society of Hematology Annual Meeting, 1/1/2013
• Evolution of Acute Myelogenous Leuekmia Stem Cell Properties Following Treatment and Progression.
  Ho, T., LaMere, M.W., O'Dwyer, K., Mendler, J.M., Liesveld, J.L., Wetzler, M., Wang, E.S., Guzman, M.L., Jordan, C.T., Becker, M.W., American Society of Hematology Annual Meeting, 1/1/2013
• Evolution of Acute Myelogenous Leuekmia Stem Cell Properties Following Treatment and Progression.
  Ho, T LaMere, M., Jordan, CT., and Becker, M.W., FASEB, Hematologic Malignaices, 1/1/2013
• Phase I Study of Decitabine and Rapamycin in Relapsed/Refractory Acute Myelogenous Leukemia.
  Liesveld JL, O'Dwyer K, Becker M.W., Mulford D, Walker A, Chen R, Bechelli J, Rosell K, Jordan CT, Minhajuddin M, Phillips GL 2nd, American Society of Hematology Annual Meeting, 1/1/2012
• Bcl-2 Inhibitor ABT-263 Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cell.
  Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Pei S, O'Dwyer KM, Liesveld JL, Brookes PS, Becker M.W., Jordan CT, American Society of Hematology Annual Meeting, 1/1/2012
• HSP70 Inhibitor, YK5, Synergizes with Chemotherapeutic Agents and Prevents Chemoresistance in Acute Myelogenous Leukemia (AML).
  Sharma, K.K., Rico, J.P., Becker, M.W., Roboz, G. J., Chiosis, G., Guzman, M.L., American Society of Hematology Annual Meeting, 1/1/2012
• Phase I Study of Eltrombopag for Promoting Thrombopoiesis in Patients Undergoing Stem Cell Transplantation After Total Body Irradiation.
  Liesveld JL, Phillips GL 2nd, Becker M.W, Constine LS, Friedberg J, Andolina JR, Milner LA, Smudzin T, Hyrien O, Dawson KL, Chen Y., American Society of Hematology Annual Meeting, 1/1/2012
• Southwest Oncology Group Study S0910: A Phase 2 Trial of Clofarabine/ Cytarabine/ Epratuzumab for Relapsed/ Refractory Acute Lymphocytic Leukemia.
  Advani, A., McDonough, S., Coutre, S., Brent L. Wood, B.L., Radich, J.P., Mims, M., O'Donnell, M., Elkins, S., Becker, M.W., Othus, M., Appelbaum, F.R., American Society of Hematology Annual Meeting, 1/1/2012
• The Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) and Survival After Extracorporeal Photopheresis, Pentostatin, and Reduced Dose Total Body Ir...
  Hashmi, ., Oliva, J.L., Liesveld, J.L., Phillips, G.L. Nichols, D. and Becker, M.W., American Society of Bone Marrow Transplantation, 1/1/2012
• HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells.
  Rico, J.P., Sharma, K.K., Kang, Y., Taldone, T., Patel, H., Brennan, Zong, H., Becker, M.W., Roboz, G. J., Chiosis, G., Guzman, M.L., American Society of Hematology Annual Meeting, 1/1/2012
• Targeting Redox Homeostasis As a Means to Selectively Eradicate Primary Human Leukemia Cells.
  Pei S, Callahan KP, Minhajuddin M, Balys M, Neering SJ, Corbett C, Becker M.W., Liesveld JL, Hagen FK, Friedman, A.E., , Crooks PA, Jordan CT, American Society of Hematology Annual Meeting, 1/1/2011
• High-Dose Therapy and Autologous Stem Cell Transplant (HD-ASCT) for Transformed Non-Hodgkin Lymphoma (NHL) In the Rituximab Era.
  Ban-Hoefen M, Friedberg JW., Kelly JL, Bernstein SH, Liesveld J, Young, F., Fisher, R.I., Constine L, Becker M.W., Phillips G, American Society of Hematology Annual Meeting, 1/1/2010
• The Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) and Survival After Extracorporeal Photopheresis, Pentostatin, and Reduced Dose Total Body Ir...
  Hashmi, ., Oliva, J.L., Liesveld, J.L., Phillips, G.L. Nichols, D. and Becker, M.W., American Society of Hematology Annual Meeting, 1/1/2010
• Alpha-Catenin Is Dispensable for Normal Hematopoietic Stem Cell Function.
  Mikhalkevich, N., Becker, M.W., American Society of Hematology Annual Meeting, 1/1/2009
• Epigenetic Suppression of the CTNNA1 Gene, Encoding the alpha-Catenin Protein, which Is Located in the 5q31 Critical Deleted Region in Malignant Myeloid Disorders with...
  Liu, T.X., Becker, M.W., Hsu, K., Jelinek, J., Deng, D., Bloomfield, C., Issa, J.P., Clarke, M.F., Look, A.T., American Society of Hematology Annual Meeting, 1/1/2004
• Phase I/II Trial on the use of Etanercept (Enbrel®) and Solumedrol as Primary Treatment for Acute Graft-Vs.-Host Disease (aGVHD).
  Uberti, JP., Ayash, L., Levine, J.E., Silver, S., Reddy, P., Becker, M.W., Reynolds, C., Cooke, K., Ratanatharathorn, V., Ferrara, J., American Society of Hematology Annual Meeting, 1/1/2003
• Join now to see all

Lectures

• Access and Referral Barriers to Autologous and Allogeneic Hematopoietic Cell Transplantation in Adult Patients with Cancer: A Systematic Review with a Specific Focus o... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Qualitative Study of Factors That Influence Treatment Decision-Making Among Community Oncologists and Older Patients with Acute Myeloid Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018

Other

• Stem Cells: Finding the Real Culprits in Cancer. 
  Clarke, M.F., and Becker, M.W.
  1/1/2006