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Office
UCLA Medical Center
10833 LeConte Ave, 57-145
Los Angeles, CA 90095Phone+1 310-794-7555Fax+1 310-794-7555
Summary
- Melissa G. Lechner, MD, PhD is an Assistant Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism at the UCLA David Geffen School of Medicine. Her clinical and research interests are related to endocrine disease resulting from cancer immunotherapy (onco-endocrinology) and advanced thyroid cancer. She established the Onco-Endocrinology clinic at UCLA to care for patients with endocrine side effects from cancer immunotherapy and targeted therapies. She also has expertise in thyroid nodules (including biopsy).
Dr. Lechner leads multiple prospective clinical trials at UCLA studying thyroid disease and cancer immunotherapy. She has received funding from the American Thyroid Association, Endocrine Fellows Foundation, and National Institutes of Health for her research and has been invited to speak nationally and internationally on the role of the immune system in cancer. She has published articles in Thyroid, The Journal of Clinical Endocrinology and Metabolism, The Journal of Immunology, Cancer, and Clinical Cancer Research, including original research and invited reviews, and serves on the National Comprehensive Cancer Network of Management of Immunotherapy Toxicity Side Effects guidance panel.
After finishing her combined MD and PhD training in the joint USC Keck School of Medicine/Cal Tech physician-scientist training program, Dr. Lechner completed residencies in internal medicine and pediatrics at Brigham and Women's Hospital and Boston Children's Hospital of the Harvard Medical School. In 2018, she joined UCLA as a clinical fellow in endocrinology and post-doctoral researcher in the prestigious Specialty Training and Advanced Research (STAR) program. In 2020, Dr. Lechner joined the faculty at UCLA.
Clinical Expertise
- Thyroid disease, Basic Science Research, Clinical and translational research, Onco-Endocrinology, Thyroiditis, Thyroid nodules and thyroid cancer, Immune toxicities of cancer immunotherapy
Education & Training
- UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Endocrinology, Diabetes, and Metabolism, 2018 - 2020
- Brigham and Women's HospitalResidency, Internal Medicine, 2015 - 2018
- Keck School of Medicine of the University of Southern CaliforniaClass of 2014
Certifications & Licensure
- CA State Medical License 2018 - 2026
- MA State Medical License 2014 - 2020
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Endocrinology, Diabetes and Metabolism
Publications & Presentations
PubMed
- 106 citationsMHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In VitroTrevor E. Angell, Melissa G. Lechner, Julie K. Jang, Jonathan S. LoPresti, Alan L. Epstein
Clinical Cancer Research. 2014-12-01 - 1 citationsThe Effect of Apalutamide on Thyroid Function in Prostate Cancer Patients.Clare Moffatt, Melissa G Lechner, Trevor E Angell, John Shen, Alexandra Drakaki
Journal of the Endocrine Society. 2024-05-23 - 34 citationsAnaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases.Garry S Brody, Dennis Deapen, Clive R Taylor, Lauren Pinter-Brown, Sarah Rose House-Lightner
Plastic and Reconstructive Surgery. 2015-03-01
Press Mentions
- New Autoimmunity Center of Excellence at UCLA Will Seek Cures for Autoimmune DisordersOctober 16th, 2024
Grant Support
- Targets for Prevention of Autoimmune Toxicities from Checkpoint ImmunotherapyAramont Charitable FoundationPresent
- Mechanisms of Thyroid Autoimmunity in Checkpoint ImmunotherapyNational Institutes of Health (NIDDK)Present
- Role of Recent Thymic T Cells in Immune Checkpoint Inhibitor ThyroiditisAmerican Thyroid AssociationPresent
Professional Memberships
- Member
- National Comprehensive Cancer NetworkMember
External Links
- Research Grouphttps://maureensulab.wixsite.com/maureensugroup
- Pubmed Bibliographyhttps://www.ncbi.nlm.nih.gov/myncbi/melissa.lechner.1/bibliography/public/
- ATA Researchhttps://www.thyroid.org/professionals/research-grants/thyroid-research-recipients-2020/
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