MandeepSinghMDPhD(He/Him)

Retinal Disease

Andreas C. Dracopoulos Professor, Associate Professor of Ophthalmology and Genetic Medicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine

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Office
1800 Orleans Street
Maumenee Lobby
Baltimore, MD 21287
Phone+1 410-955-5080

Fax+1 410-955-0869

Summary

Surgical, medical and genetic diseases of the retina

Clinical Expertise

Diabetic retinopathy, Macular degeneration, Choroidal neovascularization, Macular edema, Vitreomacular traction syndrome, Macular dystrophies, Juvenile Best macular dystrophy, Retinitis pigmentosa, Retinal detachment, Vitrectomy, Vitreous hemorrhage, Retina surgery, Clincial trials, Central retinal vein occlusion, Macular pucker, Retinal hemorrhage, Retinal degeneration, Vitreoretinal disease, Medical retina, Proliferative vitreoretinopathy, Hereditary eye diseases, Macular Hole, Stem Cell Research, Age related macular degeneration (AMD), Stargardt macular dystrophy

Education & Training

Moorfields Eye Hospital, London, UKFellowship, 2014 - 2015
Oxford Eye Hospital, UKFellowship, 2013 - 2014
University of Oxford, UKPhD, Ophthalmology, 2014
Royal College of Surgeons of EdinburghFRCSEd, Ophthalmology, 2009
National University of Singapore FOMClass of 2001, MBBS, Dean's List

Certifications & Licensure

MD State Medical License 2016 - 2025

Awards, Honors, & Recognition

Bert M. Glaser MD Award for Innovative Research in Retina Association for Research in Vision and Ophthalmology, 2019
Elected member Club Jules Gonin, 2018
Elected Member The Macula Society, 2018
Clinician Scientist Award Johns Hopkins University School of Medicine, 2016
The Ruskell Medal The Worshipful Company of Spectacle Makers, United Kingdom, 2013
Founder's Cup and Medal Oxford Ophthalmological Congress, 2011, 2013
Graduate Prize Scholarship Merton College, University of Oxford, 2011
Leadership in Academic Medicine Award 2006-2007
Service Champion Award 2001-2002
Outstanding Surgical Intern Award 2001
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Clinical Trials

A Natural History of the Progression of Stargardt Disease: Retrospective and Prospective Studies Start of enrollment: 2013 Aug 01
Completed
Phase 2 Tolerability and Effects of ALK-001 on Stargardt Disease Start of enrollment: 2015 Aug 01
Recruiting
Phase 2
The Natural History of the Progression of Atrophy Secondary to Stargardt Disease Type 4: PROM1-Related Macular Dystrophy Start of enrollment: 2014 Dec 01
Completed
The FIGHT-RP1 Study Start of enrollment: 2017 Feb 15
Completed
Phase 1
Rate of Progression in USH2A-related Retinal Degeneration Start of enrollment: 2017 Aug 11
Active, not recruiting
Natural History of the Progression of Choroideremia Study Start of enrollment: 2015 Jun 30
Completed
Efficacy and Safety of BIIB111 for the Treatment of Choroideremia Start of enrollment: 2017 Dec 11
Completed
Phase 3
Long-term Safety and Efficacy Follow-up of BIIB111 for the Treatment of Choroideremia and BIIB112 for the Treatment of X-Linked Retinitis Pigmentosa Start of enrollment: 2018 Jun 04
Enrolling by invitation
Phase 3
Safety and Efficacy of Emixustat in Stargardt Disease Start of enrollment: 2019 Jan 07
Completed
Phase 3
Rate of Progression in EYS Related Retinal Degeneration Start of enrollment: 2020 Feb 25
Active, not recruiting
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Publications & Presentations

PubMed

153 citations
Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion.
Mandeep S. Singh, Jasmin Balmer, Alun R. Barnard, Sher A. Aslam, Daniela Moralli
Nature Communications. 2016-11-30
130 citations
Retinal stem cell transplantation: Balancing safety and potential.
Mandeep S. Singh, Susanna Soon Chun Park, Thomas A. Albini, M. Valeria Canto-Soler, Henry Klassen
Progress in Retinal and Eye Research. 2020-03-01
2 citations
Spatial Characteristics of Peripheral Visual Islands in Retinitis Pigmentosa.
Tapan P Patel, Hursuong Vongsachang, Andrew Schilling, Xiangrong Kong, Mandeep S Singh
Investigative Ophthalmology & Visual Science. 2022-02-01

Books/Book Chapters

Cell-Based Therapy for Degenerative Retinal Disease
Zarbin, Marco A., Singh, Mandeep S., Casaroli-Marano, Ricardo P2019
The New Visual Neurosciences
Chapter: Retinal Cell Replacement
M. S. Singh & R. E. MacLarenEditors: John S. Werner & Leo S. Chalupa.MIT Press, MAEdition 1,2014
Current Issues in Age-Related Macular Degeneration
Chapter: Novel Approaches to Restore Vision in AMD
M. S. Singh & S. R. de SilvaEditors: C. Luu & R. Guymer.Future Science Group, LondonEdition 1,2014

Lectures

Mechanisms of Photoreceptor Transplantation
Eye Institute Vision Science Distinguished Lecture, Medical College of Wisconsin - 2019
Cellular Integration and Cytoplasmic Transfer in Photoreceptor Transplantation
National Eye Institute, NIH, Bethesda - 2019
Cell fusion after photoreceptor precursor transplantation
RD 2016 Meeting, Kyoto, Japan - 2016
Pars plana vitreolensectomy for ectopia lentis with the preservation of posterior hyaloid attachment
Club Jules Gonin, Bordeaux, France - 2016
Fact or Fiction: Stem Cell Treatment for the Retina
Current Concepts in Ophthalmology, USA - 2015
Photoreceptor Transplantation to Restore Vision in End-Stage Retinal Degeneration
World Congress on Ocular Cell and Regenerative Biology, China - 2015
Stem Cell Therapy for Inherited Eye Disorders
International Society for Genetics of Eye Diseases and Retinoblastoma, Belgium - 2013
Restoration of the Retina with Stem Cells: Fact or Fiction?
Euretina Annual Meeting, Germany - 1/1/2013
Stem Cell Treatments for Retinitis Pigmentosa
RP Fighting Blindness Patient Information Day, UK - 2011
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Press Mentions

Stem Cell ResearchMarch 30th, 2016
New Master Presents WCSM MedalOctober 12th, 2013
Blind Mice See Light After Cell TransplantJanuary 12th, 2013
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Research History

Research Associate, Nuffield Laboratory of Ophthalmology, University of Oxford, UK2014 - 2015
Honorary Research Fellow, Visual Neuroscience, UCL Institute of Ophthalmology, London UK2010 - 2010