R. James White MD PhD

PubMed

• Peak steps to measure ''capacity for activity'': Actigraphy in the ADAPT registry with oral treprostinil.
  Daniel Lachant, James Gagermeier, Scott Seaman, Andrew Wang, Meredith Broderick
  JHLT Open. 2025-05-01
• Future treatment paradigms in pulmonary arterial hypertension: a personal view from physicians, health authorities, and patients.
  Franck F Rahaghi, Marc Humbert, Marius M Hoeper, R James White, Robert P Frantz
  The Lancet. Respiratory Medicine. 2025-04-01
• Health-related quality of life and symptom concordance between patients and physicians in pulmonary arterial hypertension in the United States, Europe, and Japan.
  R James White, Dario Vizza, Rogier Klok, Julia Harley, Mark Small
  Respiratory Medicine. 2025-02-01

Journal Articles

• Thrombosis, platelets, microparticles and PAH: more than a clot  
  Lannan K. L., Phipps R. P., White R. J, Drug Discov Today, 1/1/2014
• Drug discovery in pulmonary arterial hypertension: attacking the enigmatic root of a deadly weed  
  White R. J., Lannan K. L., Phipps R. P., Drug Discov Today, 1/1/2014
• Efficacy and safety of oral treprostinil monotherapy for the treatment of pulmonary arterial hypertension: a randomized controlled trial  
  Jing, Z. C., Parikh, K., Pulido, T., Jerjes-Sanchez, C., White, R. J., Allen, R., Torbicki, A., Xu, KF, Yehle, D., Laliberte, K, Arneson, C., Rubin L., Circulation, 1/1/2013
• Subcutaneous treprostinil is welltolerated with infrequent site changes and analgesics  
  White, R. J., Levin, Y. D., Wessman, K., Heininger, A., Frutiger, K, Pulm. Circ, 1/1/2013
• miR-26a Linked to Pulmonary Hypertension by Global Assessment of Circulating Extracellular MicroRNAs  
  Schlosser, K., White, R. J., Stewart, D. J., Am J Resp Crit Care Med, 1/1/2013
• Rapid transition from inhaled iloprost to inhaled treprostinil in patients with pulmonary arterial hypertension  
  Bourge, R. C., Tapson, V. F., Safdar, Z., Benza, R. L., Channick, R. N., Rosenzweig, E. B., Shapiro, S., White, R. J., McSwain, C.S., Gotzkowsky, S.K., Nelsen, A. C., ..., Cardiovascular Therapeutics, 1/1/2013
• Pharmacokinetics of oral treprostinil diolamine sustained release tablets during chronic administration to patients with pulmonary arterial hypertension  
  White, R. J., Torres, F, Allen, R., Jerjes, C, Pulido, T., Yehle, D., Howell, M, Laliberte, K, Marier, JF, Tapson, VF, J Cardiovasc Pharmacol, 1/1/2013
• Understanding the Low Penetrance of Bone Morphogenetic Protein Receptor 2 Gene Mutations: Another Needle in the Haystack  
  White, R. J., Morrell, N. W., Circulation, 1/1/2012
• Thrombin and Platelets in Pulmonary Hypertension: A Lot More than Clot  
  White, R. J., Adv. Pulmon. Hypertens, 1/1/2012
• AHA Scientific Statement: Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension  
  McMurtry, M. S,, Archer, S.L., Cushman, M., Goldenberg, N., Goldhaber, S. Z., Jenkins, J. S., Kline, J. A., Michaels, A. D., Thistlethwaite, P. A., Vedantham, S., Whit..., Circulation, 1/1/2011
• Neonatal hyperoxia causes pulmonary vascular disease and shortens life-span in aging mice  
  Yee, M., White, R. J., Awad, H., Bates, W.A., O’Reilly, M.A., Amer J. Pathology, 1/1/2011
• Novel Therapeutic Approaches in Pulmonary Arterial Hypertension: Focus on Tadalafil  
  Levin, Y.D., White, R. J., Drugs of Today, 1/1/2011
• Inhaled Treprostinil for Pulmonary Arterial Hypertension  
  Ferrantino, M, White, R. J., Expert Opin. Pharmacotherapy, 1/1/2011
• Exercise improvement and plasma biomarker changes during intravenous treprostinil therapy for pulmonary arterial hypertension: a placebocontrolled trial  
  Hiremath, J., Thanikachalam, S., Parikh, K., Shanmugasundaram, S., Bangera, S., Shapiro, L., Pott, G.B., Vnencak-Jones, C., Arneson, C., Wade, M., White, R. J., J Heart Lung Transplant, 1/1/2010
• Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinase  
  Meoli, D.F., White, R. J., Canadian J Pharmacol Physiol, 1/1/2010
• Rationale for the judicious use of placebos in PAH trials  
  White, R. J., Hiremath, J., J Heart Lung Transplant, 1/1/2010
• Tadalafil therapy for pulmonary arterial hypertension  
  Galie, N., Brundage, B.H., Ghofrani, A., Oudiz, R. J., Simonneau, G., Safdar, Z., Shapiro, S., White, R. J., Chan, M., Beardsworth, A., Frumkin, L., Barst, R. J., Circulation, 1/1/2009
• Sildenafil improves hemodynamics in liver transplantation candidates with pulmonary hypertension  
  Gough, M.S. and White, R.J., Liver Transplant, 1/1/2009
• Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium-calmodulin dependent protein kinase II  
  Meoli, D.F., White, R. J., Am J Physiol: Lung Cell Molec Physiol, 1/1/2009
• Update on the development of oral prostacyclin analogs for the treatment of pulmonary arterial hypertension  
  White, R. J., Adv. Pulmon. Hypertens, 1/1/2009
• Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary hypertension  
  White, R.J., Meoli, D.F., Swarthout, R.F., Kallop, D.Y., Galaria, I.I., Harvey, J.L., Miller, C.M., Blaxall, B.C., Hall, C.M., Pierce, R.A., Cool, C.D., Taubman, M.B., Am J Physiol: Lung Cell Mol Physiol, 1/1/2007
• Tissue factor is induced in a rodent model of severe pulmonary hypertension characterized by neointimal lesions typical of human disease  
  White, R.J., Galaria, I.I., Harvey, J., Blaxall, B.C., Cool, C.D., Taubman, M.B., Chest, 1/1/2005
• A “Radical” Idea Comes of Age: Mitochondrial Oxidant Signaling in Health and Disease  
  White, R.J., Journal of Molecular and Cellular Cardiology, 1/1/2004
• Pulmonary Arterial Hypertension: Building a Better Mouse Trap for 2010  
  White, R.J., Drug Discovery Today: Therapeutic Strategies, 1/1/2004
• Mitochondria Accumulate Ca2+ Following Intense Glutamate Stimulation Of Cultured Forebrain Neurones  
  White, R.J. and Reynolds, I.J., J Physiol (Lond), 1/1/1997
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Books/Book Chapters

• Lung injury: Mechanisms, pathophysiology and treatment 
  Chapter: Gene therapy for lung injury 
  Sime P.J., White R.J., Kolb M, Hitt M, and Gauldie J.Editors: Notter, R, Finkelstein, J, and Holm.Marcel-Dekker, New York, NY2004

Abstracts/Posters

• Sex-specific response to therapy in rats with severe PAH
  White, RJ., Mini-Symposium, 1/1/2013
• Ixolaris, a Tissue Factor Inhibitor, Preserves Vascular Perfusion as Assessed by Quantitative Micro CT Scan in Rats with Established Pulmonary Arterial Hypertension (PAH)
  Meoli, DF, Haight, D, Franciscetti, I, Awad, H, White, RJ., Amer J Resp Crit Care Med, 1/1/2009
• Thrombin Induces Fibronectin-Dependent Migration of Pulmonary Microvascular Endothelial Cells: Involvement of v 3 Integrin, Talin Phosphorylation, and Calcium Signaling
  Meoli, DF, White, RJ, Amer J Resp Crit Care Med, 1/1/2009
• Sustained Plasma Concentrations of Treprostinil Following Chronic Dosing in Patients with Pulmonary Arterial Hypertension (PAH)
  White, RJ, Allen, R, Torres, F, Jerjes, C, Pulido, T, Carroll, J, Yehle, D, Laliberte, K, Mottola, D, Galie, N, Simmoneau, G, Tapson, VF, Amer J Resp Crit Care Med, 1/1/2009
• Oral Treprostinil Diethanolamine Provides Sustained Therapeutic Plasma Levels over a Wide Range of Doses in Patients with Pulmonary Arterial Hypertension
  White, RJ, R. Allen, D. Yehle, K. Laliberte, D. Mottola, N. Galie, G. Simonneau, V.F. Tapson, Amer J Resp Crit Care Med, 1/1/2008
• Intravenous Treprostinil Reduced Angiopoietin-2 Levels during 12 Weeks of Blinded Therapy: A Study of 11 Biomarkers in Pulmonary Arterial Hypertension
  White, RJ, M. Wade, C. Arneson, Amer J Resp Crit Care Med, 1/1/2008
• Calcium Calmodulin-Dependent Protein Kinase II (CaMKII) Specifically Mediates Thrombin/Fibronectin-Induced Migration of Pulmonary Microvascular Endothelial Cells
  Meoli, DF, White, RJ, Amer J Resp Crit Care Med, 1/1/2008
• Ixolaris, a Tissue Factor Inhibitor, Reduces Vascular Pruning and Delays Death in Rats with Established Pulmonary Arterial Hypertension
  D.F. Meoli, R.F. Swarthout, M.B. Taubman, R.J. White, Amer J Resp Crit Care Med, 1/1/2008
• Proliferating Vascular Lesions with a Plexiform Appearance in a Rodent Model of Severe Pulmonary Hypertension: Tissue Factor is Abnormally Expressed
  White, RJ, Harvey, J, Galaria, II, Moore, CH, Pierce, RA, Miller, CE, Georger, MA, Taubman, MB, Cool, CD, Am J Resp Crit Care Med, 1/1/2004
• Mitochondrial Calcium Uptake is Altered in Liver Mitochondria Isolated from Endotoxin Treated Rats
  White, RJ, Rice, EJ, Gunter, KK, Callahan, LA, Supinski, GS, Am J Resp Crit Care Med, 1/1/2002
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Lectures

• Pulmonary Arterial Hypertension: Breathing Easier 
  Multiple locations, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012 - 1/1/2014
• Clinical update on Prostacyclins as Early Therapy for Advanced PAH 
  Multiple locations, 2008, 2009, 2013, 2012 - 1/1/2014
• Tissue Factor in Severe Pulmonary Arterial Hypertension 
  Multiple locations, 2005, 2007, 2008, 2009, 2010, 2011, 2012 - 1/1/2012