JakubTolarMDPhD

PubMed

• 165 citations
  Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect
  Martin Felices, Alexander J. Lenvik, Ron T. McElmurry, Sami Chu, Peter Hinderlie
  JCI Insight. 2018-02-08
• 204 citations
  Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umb...
  Claudio G. Brunstein, Daniel J. Weisdorf, Todd E. DeFor, Juliet N. Barker, Jakub Tolar
  Blood. 2006-10-15
• 68 citations
  Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs
  Mark J. Osborn, Gregory A. Newby, Amber N. McElroy, Friederike Knipping, Sarah C. Nielsen
  The Journal of Investigative Dermatology. 2020-02-01

Journal Articles

• Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho  
  Bruce R Blazar, Heather E Stefanski, Sarah L Parker, Jakub Tolar, The Journal of Immunology
• Outcome of Haematopoietic Stem Cell Transplantation in Dyskeratosis Congenita*  
  Jakub Tolar, MD, British Journal of Haematology
• Prediction of DNA-binding propensity of proteins by the ball-histogram method  
  Szaboova A, KuZelka O, Morales E, Zelezny F, Tolar J, Lect Notes Comput Sc, 1/1/2011
• Cross-genome knowledge-based expression data fusion  
  Holec M, Klema J, Zelezny F, Benadsky J, Tolar J, International Conference on Bioinformatics, Computational Biology, Genomics and Chemoinformatics, 1/1/2009
• Relational subgroup discovery for descriptive analysis of microarray data  
  Trajkovski I, Zelezny F, Tolar J, Lavrac N, Lect Notes Comput Sc, 1/1/2006
• Summarizing gene-expression-based classifiers by meta-mining comprehensible relational patterns  
  Zelezny F, Tolar J, Lavrac N, Stepankova O, Proceedings of the Fourth IASTED International Conference on Biomedical Engineering, 1/1/2006
• Relational Subgroup Discovery for Gene Expression Data Mining  
  Zelezny F, Tolar J, Lavrac N, Stepankova O, Proceedings of EMBEC: the 3rd European Medical & Biological Engineering Conference/IFMBE European Conference on Biomedical Engineering, 1/1/2005
• New approaches in pediatric hematopoietic stem cell transplantation  
  Tolar J, Baker KS, Ebonyi Medical Journal, 1/1/2003
• Issues surrounding prenatal genetic testing for achondroplasia  
  Gooding HC, Boehm K, Thompson RE, Hadley D, Francomano CA, Biesecker BB, Prenat Diagn, 1/1/2002
• Comprehensive Resource: Skeletal Gene Database  
  Jia L, Ho NC, Park SS, Powell J, Francomano CA, Am J Med Genet (Sem Med Genet), 1/1/2002
• Early age-related maculopathy and self-reported visual difficulty in daily life  
  Scilley, K., Jackson, G.R., Cideciyan, A.V., Maguire, M.G., Jacobson, S.G. and Owsley, C., Ophthalmology, 1/1/2002
• Prevalence of aortic root dilation in Ehlers-Danlos Syndrome  
  Wenstrup RJ, Meyer RA, Lyle JS, Hoechstetter L, Rose PS, Levy HP, Francomano CA, Genetics in Medicine, 1/1/2002
• The influence of pulsed low-intensity ultrasound on matrix production of chondrocytes at different stages of differentiation: an explant study  
  Zhang ZJ, Huckle J, Francomano CA, Spencer RG, Ultrasound Med Biol, 1/1/2002
• Invited Commentary  
  Cummings, CW, Principles and Practice of Geriatric Surgery, 1/1/2001
• Phenotypic marker for early disease detection in dominant late-onset retinal degeneration  
  Jacobson, S.G., Cideciyan, A.V., Wright, E. and Wright, A.F., Invest Ophthalmol Vis Sci, 1/1/2001
• Characterization of a human gene for nucleosomal binding protein, NSBP1  
  King L and Francomano CA, Genomics, 1/1/2001
• Melatonin delays photoreceptor degeneration in the rds/rds mouse  
  Liang, F.Q., Aleman, T.S., Yang, Z., Cideciyan, A.V., Jacobson, S.G. and Bennett, J., Neuroreport, 1/1/2001
• Thoracolumbar spinal abnormalities in Stickler syndrome  
  Rose PS, Ahn NU, Levy HP, Ahn UM, Davis J, Liberfarb RM, Nallamshetty L, Sponsellar PD, Francomano CA, Spine, 1/1/2001
• Four novel mutations in the RPE65 gene in patients with Leber congenital amaurosis  
  Simovich, M.J., Miller, B., Ezzeldin, H., Kirkland, B.T., McLeod, G., Fulmer, C., Nathans, J., Jacobson, S.G. and Pittler, S.J., Hum Mutat, 1/1/2001
• Auditory dysfunction in Stickler syndrome  
  Szymko-Bennett YM, Mastroianni MA, Shotland LI, Davis J, Ondrey FG, Balog JZ, Rudy SF, McCullagh L, Levy HP, Liberfarb RM, Francomano CA, Griffith AJ, Arch Otolaryngol Head and Neck Surg, 1/1/2001
• CNGA3 mutations in hereditary cone photoreceptor disorders  
  Wissinger, B., Gamer, D., Jagle, H., et al., Jacobson, S.G., et al., Kohl, S., Am J Hum Genet, 1/1/2001
• Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype  
  Bellus GA, Spector EB, Speiser PW, Weaver CA, Garber AT, Bryke CR, Israel J, Rosengren SS, Webster MK, Donoghue DJ, Francomano CA, Am J Hum Genet, 1/1/2000
• Metastasizing Mixed Tumor of the Parotid  
  Czader M., Eberhart CG, Bhatti N, Cummings, CW, Westra W, American Journal of Surgical Pathology, 1/1/2000
• Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate  
  Haider, N.B., Jacobson, S.G., Cideciyan, A.V., Swiderski, R., Streb, L.M., Searby, C., Beck, G., Hockey, R., Hanna, D.B., Gorman, S., Duhl, D., Carmi, R., Bennett, J.,..., Nature Genet, 1/1/2000
• Jeune asphyxiating thoracic dystrophy and short-rib polydactyly type III (Verma-Naumoff) are variants of the same disorder  
  Ho NC, Francomano CA, van Allen M, Am J Med Genet, 1/1/2000
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Books/Book Chapters

• Data Mining and Medical Knowledge Management: Cases and Applications. 
  Chapter: Gene Expression Mining Guided by Background Knowledge. 
  Klema J, Zelezny F, Trajkovski I, Karel F, Cremilleux B, Tolar JEditors: Berka P, Rauch J, Zighed DA.IGI Global2009
• Data Mining and Medical Knowledge Management: Cases and Applications. 
  Chapter: Gene expression data mining guided by genomic background knowledge. 
  Klema J, Zelezny F, Trajkovski I, Karel F, Cremilleux B, Tolar JEditors: Berka P.IGA Global, IDEA Group Publishing, Hershey, PAEdition 1st,2008

Abstracts/Posters

• Plasma and intracellular population pharmacokinetic analysis of fludarabine in pediatric allogeneic hematopoietic cell transplant (alloHCT) recipients.
  Long-Boyle J, Sambol N, Dvorak CC, Cowan MJ, Lee S, Huang LS, Horn B, Stricherz M, Tolar J, Orchard P, Jacobson P, Aweeka F, Biol Blood Marrow Transplant, 1/1/2014
• Toxic epidermal necrolysis (TEN) in recessive dystrophic epidermolysis bullosa status post hematopoietic stem cell transplant.
  Sajic D, Hook K, Tolar J, 89th Canadian Dermatology Association Annual Conference, 1/1/2014
• Effects of vitronectin on neural differentiation and proliferation of human iPSC’s in 3D cell culture.
  Venhuizen S, Lindborg B, Haider K, Ulrich C, Vegoe A, Subramaniam S, Brekke JH, Dutton J, Tolar J, O’Brien TD, Cornell University Merial-NIH Veterinary Scholars Symposium, 1/1/2014
• Biopacemaker cells and 2-dimensional cardiac tissue sheet derived from human induced pluripotent stem cells.
  Xia L, Keirstead S, Eide C, Tolar J, Hearth Rhythm, 1/1/2014
• Mesenchym stem cells in the tumor immunosuppressive barrier.
  Modiano J, Lindborg B, Lewellen M, McElmurry R, Tolar J, Zamora E, Schaack J, Bellgrau D, O’Brien T, Keystone Symposia, 1/1/2013
• Potential of deriving iPSC from peripheral blood T cells using retroviral approach.
  Parker S, Jensen M, Bared K, Tolar J, Blazar B (co-last authors), International Society for Stem Cell Research Meeting, 1/1/2013
• Systemic cell therapy for epidermolysis bullosa: repair of skin extracellular matrix.
  Tolar J, McGrath JA, Keene DR, Hook K, Osborn MJ, Hordinsky M, Woodley D, Chen M, Hovnanian A, Tamai K, Blazar BR, Wagner JE, Hum Gene Ther, 1/1/2013
• Bone marrow transplantation has better outcomes than umbilical cord blood transplantation in recessive dystrophic epidermolysis bullosa (RDEB).
  Tolar J, McGrath JA, Keene DR, Hook K, Osborn MJ, Kavand S, Hordinsky M, Woodley D, Chen M, Hovnanian A, Tamai K, Blazar BR, Wagner JE, Minnesota Dermatological Society Annual Meeting, 1/1/2013
• Education and cytokine receptor balance play a critical role in the long term survival of the most differentiated natural killer (NK) cells.
  Felices M, Lenvik T, Ankarlo D, Curtsinger J, Tolar J, Blazar BR, Anderson S, Miller JS, Blood, 1/1/2012
• Encouraging survival for patients who had a second umbilical cord blood transplant for graft failure.
  Lund TC, Verneris MR, Tolar J, Cao Q, Weisdorf DJ, Wagner JE, Brunstein CG, Biol Blood Marrow Transplant, 1/1/2012
• Transcription activator-like effector nuclease-based genome editing for Fanconi anemia (FA).
  Osborn MJ, Starker CG, DeFeo AP, Voytas DF, Wagner JE, Blazar BR, Tolar J, Hum Gene Ther, 1/1/2012
• Suction blister technique to evaluate skin fragility in children with recessive dystrophic epidermolysis bullosa (RDEB) treated with immunomyeloablative chemotherapy a...
  Bertin AJ, Tolar J, Osborn M, Hordinsky M, Wagner JE, J Invest Dermatol; Society for Investigative Dermatology, Phoenix, AZ, 1/1/2011
• Anesthetic outcomes of children with epidermolysis bullosa undergoing bone marrow transplantation.
  Beebe D, George P, Hertel T, Tolar J, Belani K, Laberge T, Wagner J, Anesth Analg; International Anesthesia Research Society, Vancouver, Canada, 1/1/2011
• Clinical vs Surgical Fistula Failure Risk Assessment.
  Joarder M, Moist L, Lee T, and Lok C, J Am Soc Nephrol, 1/1/2011
• Comparative evaluation of set-level techniques in microarray classification.
  Klema J, Holec M, Zelezny F, Tolar J, 7th International Symposium on Bioinformatics Research and Applications, 1/1/2011
• Dyskeratosis congenita: a literature and database review of immune status and stem cell transplantation data.
  Korthof ET, Van der Zalm JJJW, Bresters D, Raphael MF, Tolar J, Bekassy A, Güngör T, Ayas M, Albert M, Touzot F, Bacigalupo A, Fasth A, Diaz M, Veys P, Cossu F, Yabe M..., Bone Marrow Transplant; European Group for Blood and Marrow Transplantation Meeting, 1/1/2011
• Evaluating Vascular Access Process of Care Measures in Advanced Chronic Kidney Disease Patients.
  Lee T, Lancaster E, Williams A, Roy-Chaudhury P, Thakar CV, J Vasc Access, 1/1/2011
• Prolonged Cumulative Survival in Fistulas with Surgical Interventions to Promote Maturation Compared to Endovascular Interventions.
  Lee T, Tindni A, Roy-Chaudhury P, J Am Soc Nephrol, 1/1/2011
• Comparsion of Cellular Phenotypes Between Pre-Existing Venous Neointimal Hyperplasia Prior to Access Surgery and Venous Neointimal Hyperplasia from Stenotic Grafts and...
  Lee T, Wang Y, Krishnamoorthy M, Chauhan V, Arend L, Corneus V, Mistry M, Munda, R, Roy-Chaudhury P, J Vasc Access, 1/1/2011
• Prediction of DNA-binding propensity of proteins by the Ball-Histogram method.
  Szaboova A, KuZelka O, Zelezny F, Morales S, Tolar J, 7th International Symposium on Bioinformatics Research and Applications, 1/1/2011
• Prediction of DNA-binding propensity of proteins using distributions of charged amino acids in primary structure.
  Szaboova A, KuZelka O, Zelezny F, Tolar J, Association for Computing Machinery Conference on Bioinformatics, Computational Biology & Biomedicine, 1/1/2011
• Searching for important amino acids in DNA-binding proteins for histogram methods.
  Szaboova A, KuZelka O, Zelezny F, Tolar J, ISBRA IEEE/ACM Transactions on Computational Biology and Bioinformatics, 1/1/2011
• Analysis of glycosaminoglycans in cerebrospinal fluid and urine using tandem mass spectrometry: potential for therapeutic monitoring of patients with mucopolysaccharid...
  Zhang H, Auray-Blais C, Young SP, Orchard P, Tolar J. Millington DS, American Society for Mass Spectrometry Meeting, 1/1/2011
• Outcome of penetrating keratoplasty for mucopolysaccharidoses.
  Decanini A, Bothun ED, Summers CG, Orchard PJ, Tolar J, World Cornea Congress, 1/1/2010
• Zmpste24-/- mice, a murine model of human progeria, display atrophic skeletal muscles while function is selectively preserved.
  Greising SM, Tolar J, Blazar BR, Lowe DA, First Annual Mayo Clinic Robert and Arlene Kogod Center on Aging Conference, 1/1/2010
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Lectures

• Reduced Intensity Conditioned Bone Marrow Transplant with Post-Transplant Cyclophosphamide and Donor-Derived Mesenchymal Stromal Cell Infusions for Recessive Dystrophi... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Cellular Therapy: Concepts and Plans 
  Osaka, Japan - 1/14/2014
• Immunity in Genetic Disorders, Cancer, and Bone Marrow Transplant 
  University of Minnesota Children’s Hospital, Minneapolis, MN - 1/11/2014
• Morning Report: 14 Simultaneous Sessions 
  1/7/2014
• Bone Marrow Failure 
  1/6/2014
• Getting Promoted as a Clinician Educator 
  1/4/2014
• Milestones and Evaluations 
  1/1/2014
• Feedback, Evaluation, Milestones 
  1/1/2014
• Implementing a Curriculum—What, Where, Why, and How for Chief Residents 
  1/30/2013
• Morning Report: 14 Simultaneous Sessions 
  1/29/2013
• Educational Innovation Roundtable 
  1/23/2013
• Congenital Cytopenias 
  1/22/2013
• Working Laboratory Tour 
  1/12/2013
• The NAS, EPAs, and Milestones 
  1/10/2013
• Osteopathic Treatments within the Pediatric Population. 
  1/1/2013
• Case conference on hyperinsulinism 
  1/1/2012
• Effects of Dextrose Injections in Treatment of Osgood-Schlatter Disease. 
  1/1/2012
• Hematopoietic and Mesenchymal Stem Cell Transplantation for Recessive Dystrophic and Junctional Epidermolysis Bullosa 
  Phoenix, AZ - 1/5/2011
• Bone Marrow Failure Syndromes 
  1/17/2010
• Pediatric SAA Algorithm & Iron Overload Algorithm 
  University of Minnesota, Minneapolis, MN - 1/15/2010
• The Efficient Clinical Session 
  1/14/2010
• Bone Marrow Failure in Children 
  1/5/2010
• BMT for ICU Physicians 
  University of Minnesota, Minneapolis, MN - 1/16/2009
• Dystrophic Epidermolysis Bullosa: New Approach to Treating this Devastating Disease 
  University of Minnesota, Minneapolis, MN - 1/15/2009
• Bone Marrow Transplantation for Epidermolysis Bullosa Therapy: current challenges and future prospects. 
  Vienna, Austria - 1/7/2009
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Other

• Biological characterization of naturally occurring mutations in an oncogenic variant of human papillomavirus type 11, PhD thesis, directed by Anthony J. Faras, PhD. 
  Tolar J
  1/1/1996