JacobJ.H.BleesingMD

PubMed

• 8 citations
  Daratumumab for the management of autoimmune cytopenias in children and young adults: a case series.
  Pooja Khandelwal, Ashley Teusink-Cross, Ashish R Kumar, J.J. Bleesing, Parinda A. Mehta
  British Journal of Haematology. 2021-05-27
• 19 citations
  Successful Bone Marrow Transplantation for XMEN: Hemorrhagic Risk Uncovered.
  Dimana Dimitrova, Jeremy J. Rose, Gulbu Uzel, Jeffrey I. Cohen, Koneti V Rao
  Journal of Clinical Immunology. 2019-01-01
• 13 citations
  Ruxolitinib for the treatment of chronic GVHD and overlap syndrome in children and young adults.
  YunZu Michele Wang, Ashley Teusink-Cross, Yasser Elborai, M. Christa Krupski, Adam S. Nelson
  Transplantation. 2021-03-26

Journal Articles

• The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency  
  Gámez-Díaz L, August D, Stepensky P, Revel-Vilk S, Seidel MG, Noriko M, Morio T, Worth AJ, Van de Veerdonk F, Feuchtinger T, Kanariou M, Schmitt-Graeff A, Jung S, Sene..., J Allergy Clin Immunol, 1/1/2016
• Defects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome  
  Lindsley AW, Saal HM, Burrow TA, Hopkin RJ, Shchelochkov O, Khandelwal P, Xie C, Filipovich L, Risma K, Assa'ad AH, Roehrs PA, Bernstein JA, J Allergy Clin Immunol, 1/27/2015
• Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial  
  Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT, Blood, 1/26/2015
• Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy  
  Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Fili..., Science., 1/24/2015
• Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation  
  Pate A, Rotz S, Warren M, Hirsch R, Cash M, Myers KC, El-Bietar J, Nelson A, Wallace G, Filipovich AH, Chima RS, Davies SM, Jodele S, Dandoy CE, Bone Marrow Transplant, 1/19/2015
• Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency  
  Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Grimley MS, Malech H, De Rav..., J Clin Invest., 1/12/2015
• Accuracy of flow cytometric perforin screening for detecting patients with FHL due to PRF1 mutations  
  Abdalgani M, Filipovich AH, Choo S, Zhang K, Gifford C, Villanueva J, Marsh RA, Blood, 1/8/2015
• A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome  
  Kucuk ZY, Marsh R, Zhang K, Davies S, Filipovich AH, J Allergy Clin Immunol, 1/1/2015
• Outcomes of Donor Lymphocyte Infusion for Treatment of Mixed Donor Chimerism Following a Reduced Intensity Preparative Regimen for Pediatric Patients with Non-Malignan...  
  Haines HL, Davies S, Hornung L, Jordan MB, Marsh RA, Filipovich AH, Biol Blood Marrow Transplant., 1/1/2015
• Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveal...  
  Marsh RA, Rao MB, Gefen A, Bellman D, Mehta PA, Khandelwal P, Chandra S, Jodele S, Myers KC, Grimley M, Dandoy C, El-Bietar J, Kumar AR, Leemhuis T, Zhang K, Jordan MB..., Biol Blood Marrow Transplant., 1/1/2015
• Refined diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a prospective study in children and young adults  
  Jodele S, Davies SM, Lane A, Khoury J, Dandoy C, Goebel J, Myers K, Grimley M, El-Bietar J, Wallace G, Chima RS, Paff Z, Laskin BL, Blood, 1/29/2014
• IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome  
  Niss O, Sholl A, Hildeman DA, J Allergy Clin Immunol, 1/27/2014
• Clinical flow cytometric screening of SAP and XIAP expression accurately identifies patients with SH2D1A and XIAP/BIRC4 mutations  
  Gifford CE, Weingartner E, Villanueva J, Johnson J, Zhang K, Filipovich AH, Marsh RA, Cytometry B Clin Cytom., 1/19/2014
• The successful use of alemtuzumab for treatment of steroid-refractory acute graft-versus-host disease in pediatric patients  
  Khandelwal P, Lawrence J, Filipovich AH, Davies, SM, Jordan MB, Mehta P, Jodele S, Grimley MS, Kumar A, Myers K, Marsh RA, Pediatr Transplant., 1/18/2014
• Reduced Intensity Conditioning Hematopoietic Cell Transplantation is an Effective Treatment for Patients with SAP Deficiency / X-linked Lymphoproliferative Disease Type 1  
  Marsh RA, Chandrakasan S, Jordan MB, Davies SM, Filipovich AH, Biol Blood Marrow Transplant, 1/9/2014
• Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of seve...  
  Dvorak CC, Hassan A, Slatter MA, Hönig M, Lankester AC, Buckley RH, Pulsipher MA, Davis JH, Güngör T, Gabriel M, Bunin N, Sedlacek P, Connelly JA, Crawford DF, Notaran..., J Allergy Clin Immunol, 1/7/2014
• Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells  
  Felgentreff K, Du L, Weinacht KG, Dobbs J, Bartish M, Giliani S, Schlaeger T, DeVine A, Schambach A, Woodbine LJ, Davies G, BaxiSN, van der Burg M, Gennery A, Manis J,..., Proc Natl Acad Sci U S A, 1/2/2014
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  Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernández KS, Guo D, Har..., N Engl J Med, 1/1/2014
• Primary Immune Deficiency Treatment Consortium (PIDTC) report  
  Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ,..., J Allergy Clin Immunol, 1/1/2014
• A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency  
  Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, Ledeist F, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hos..., J Allergy Clin Immunol, 1/1/2014
• An intermediate alemtuzumab schedule reduces the incidence of mixed chimerism following reduced intensity conditioning hematopoietic cell transplantation for hemophago...  
  Marsh RA, Kim MO, Liu C, Bellman D, Hart L, Grimley M, Kumar A, Jodele S, Myers KC, Chandra S, Leemhuis T, Mehta P, Davies SM, Jordan MB, Filipovich AH, Biol Blood Marrow Transplant, 1/10/2013
• Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D  
  Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Marsh RA, Kuijpers TW, Nichols KE, ..., Science., 1/1/2013
• Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens  
  Chellapandian D, Das R, Zelley K, Wiener SJ, Zhao H, Teachey DT, Nichols KE; EBV-HLH Rituximab Study Group, Br J Haematol., 1/1/2013
• Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis  
  Mellor-Heineke S, Villanueva J, Jordan MB, Marsh R, Zhang K, Filipovich AH, Risma KA, Front Immunol, 1/1/2013
• Flow Cytometric Measurement of SLAM-Associated Protein and X-Linked Inhibitor of Apoptosis  
  Marsh RA, Filipovich AH, Methods Mol Biol., 1/1/2013
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Books/Book Chapters

• Clinical Immunology: Principles and practice 
  Chapter: Assessment of Functional Immune Responses 
  JJ Bleesing, KA RismaEditors: TA Fleisher, BL Kotzin, RR Rich, HW Schroeder, WT Shearer.Elsevier, LondonEdition 3rd,2008
• Current Protocols in Immunology 
  Chapter: Assays for B Cell and Germinal Center Development (unit 7.34) 
  Bleesing JEditors: JE Coligan, BE Bierer, DH Margulies, EM Shevach, W Strober.JohnWiley & Sons, Hoboken2004
• Immunologic Disorders in Infants and Children 
  Chapter: Autoimmune lymphoproliferative syndrome (ALPS) 
  TA Fleisher, JM PuckEditors: ER Stiehm, HD Ochs, JA Winkelstein.WB Saunders, PhiladelphiaEdition 5th,2004
• Manual of Allergy and Immunology 
  Chapter: Diagnostic Immunology 
  TA Fleisher, JJ BleesingEditors: DC Adelman, J Corren, T Casale.Lippincott Williams & Wilkins, BostonEdition 4th,2002
• Clinical Immunology: Principles and practice 
  Chapter: Flow cytometry 
  TA Fleisher, JJ Bleesing, GE MartiEditors: TA Fleisher, BL Kotzin, RR Rich, HW Schroeder, WT Shearer.Harcourt, LondonEdition 2nd,2001
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Abstracts/Posters

• Characterizing Autoimmune Hemolytic Anemia in RAG Deficiency
  Jack Bleesing, 61st Annual American Society of Hematology Meeting, 61st Annual American Society of Hematology Meeting - Orlando, FL, 12/9/2019
• Abnormal selection and B cell memory in human Fas deficiency
  NS Longo, JJH Bleesing, JK Dale, TA Fleisher, SE Straus, PE Lipsky, Experimental Biology (FASEB) meeting, 1/1/2004
• Abnormal selection and B cell memory in ALPS
  NS Longo, JJH Bleesing, JK Dale, TA Fleisher, SE Straus, PE Lipsky, Keystone Symposium, “B cells and antibodies: Laboratory to clinic”, 1/1/2003
• Different PSGL-1 expression patterns on T cells as determined by 2 PSGL-1 specific monoclonal antibodies
  A Bryson, T Fleisher, 19th Regional Texas Immunology Conference, 1/1/2001
• Human lymphocyte subsets express an equivalent of the murine CD45R isoform B220
  J Bleesing, TA Fleisher, First Annual Meeting Of The Federation Of Clinical Societies, 1/1/2001
• Selective loss of B cells expressing CD27 in patients with Chronic Granulomatous Disease
  WJ Savage, MR Brown, Novicio C, HL Malech, TA Fleisher, First Annual Meeting Of The Federation Of Clinical Societies, 1/1/2001
• Gridlock in the peripheral blood of patients with Autoimmune Lymphoproliferative Syndrome
  M Brown, J Bleesing, J Dale, S Straus, T Fleisher, First Annual Meeting Of The Federation Of Clinical Societies, 1/1/2001
• A Phase I/II Study of the Efficacy and Toxicity of Humanized Anti-Tac (HAT, Zenapax®) for the Treatment of Tac-Expressing Human Lymphotropic Virus Type-1 (HTLV-1)-Asso...
  JC Morris, J Janik, C Lee, L Top, M Turner, M Stetler-Stevenson, J Bleesing, TA Fleisher, TA Waldmann, 10th International Conference on Human Retrovirology: HTLV and Related Viruses, 1/1/2001
• The abnormal T cells in Large Granular Lymphocyte Leukemia express a novel CD45R isoform, similar to patients with the Autoimmune Lymphoproliferative Syndrome
  J Janik, TA Fleisher, 43rd annual meeting of the American Society of Hematology, 1/1/2001
• Reduced CD27 positive B cells in the peripheral blood of patients with autoimmune lymphoproliferative syndrome (ALPS)
  MR Brown, JK Dale, SE Straus, TA Fleisher, Joint Annual Meeting Of The American Association Of Immunologists And Clinical Immunology Society, 1/1/2000
• Alpha/beta+CD4-CD8- T cells (alpha/beta-DNT cells) in humans with the autoimmune lymphoproliferative syndrome express the CD45 isoform B220, characteristic of murine l...
  SE Straus, TA Fleisher, Joint Annual Meeting Of The American Association Of Immunologists And Clinical Immunology Society, 1/1/2000
• Proliferating T-cells increasingly express the murine CD45 isoform B220 after stimulation with Staphylococcal enterotoxin B (SEB)
  MR Morrow, JJH Bleesing, TA Fleisher, Joint Annual Meeting Of The American Association Of Immunologists And Clinical Immunology Society, 1/1/2000
• B cell reconstitution following non-myeloablative, T cell depleted, allogeneic peripheral blood cell transplant (PBSCT)
  WJ Savage, JJH Bleesing, MR Brown, GM Linton, HL Malech, ME Horwitz, Annual Meeting Of The American Society Of Blood And Marrow Transplantation, 1/1/2000
• Normal ranges for memory B cell lymphocytes
  MR Brown, ML Vail, JH Bleesing, TA Fleisher, 14th Annual Meeting Of The Clinical Cytometry Society, 1/1/1999
• The double negative T cell compartment in normals
  DL Guarraia, TA Fleisher, 14th Annual Meeting Of The Clinical Cytometry Society, 1/1/1999
• Outcome of repeated allogeneic stem cell transplantations in children, transplanted between 1968 and 1997
  PM Hoogerbrugge, MH van Weel, JM Vossen, Combined ISH-EHA Haematology Congress, 1/1/1998
• Intensified conditioning regimen in children transplanted for AML in first and ALL in second remission
  PM Hoogerbrugge, HPM Versluis, ER van Wering, JFW Weerden, A van der Does-v.d Berg, M van Weel, M van Rossum, L van ‘t Veer, JH Bleesing, JM Vossen, Combined ISH-EHA Haematology Congress, 1/1/1998
• Incidence of chronic graft versus host disease in children after bone marrow transplantation with either matched unrelated or family donors
  E de Vries MML van Diepen, M Oudshoorn, JWLT Lie, JJH Bleesing, JMJJ Vossen, Annual Meeting Of The European Group For Blood And Marrow Transplantation, 1/1/1997
• Development of T-cell function after post-natal thymic transplantation for DiGeorge syndrome
  ML Markert, FE Ward, D Kostyu, RH Buckley, SE Schiff, JJH Bleesing, CB Broome, RM Ungerleider, JW Gaynor, SM Mahaffay, KT Oldham, TJ Watson, TM McLaughlin, BF Haynes, Annual Meeting Of The American Association Of Immunologists, 1/1/1995
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Lectures

• Becoming Curators of the Total Testing Process 
  Massachusetts General Hospital - 1/1/2015
• Towards a Complete Understanding of ALPS 
  Giannina Gaslini Hospital and Research Institute, Genoa, Italy - 1/1/2015
• When is Neutropenia a Sign of Primary Immunodeficiency Disorder 
  1/1/2015
• Autoimmune Lymphoproliferative Disease 
  1/1/2014
• Bone Marrow Transplantation for the Treatment of PIDs 
  Recife, Brazil - 1/1/2013
• Diagnosis and Management of HLH 
  Recife, Brazil - 1/1/2013
• Laboratory approach to diagnosis and follow-up: what is it that really matters 
  1/1/2011
• The Diagnosis and Treatment of HLH 
  1/1/2010
• Stem Cell Transplantation for Primary Immunodeficiency Disorders 
  1/1/2009
• Autoimmune Lymphoproliferative Syndrome (ALPS): Models for Lymphocyte Homeostasis and Regulation 
  1/1/2009
• Human Immunology: Primary Immunodeficiencies as Models for Understanding Lymphocyte Development and Differentiation 
  Seattle, WA - 1/1/2009
• Allogeneic Hematopoietic Stem Cell Transplantation for Primary Immune Deficiency Diseases: Feasibility and Immune Reconstitution 
  Bethesda, MD - 1/1/2008
• Defects of Lymphocyte Homeostasis in Humans 
  1/1/2007
• Myth busters of the Immune System 
  Arkansas Children’s Hospital, Little Rock, AR - 1/1/2007
• ALPS, the Second Decade 
  Buenos Aires, Argentina - 1/1/2006
• Monitoring B-cell Depletion Therapy 
  CCHMC, Cincinnati, OH - 1/1/2006
• Autoimmune Cytopenias, a Matter of Immunologic Diplomacy 
  Buenos Aires, Argentina - 1/1/2006
• X-linked Proliferative Disease 
  Miami Beach, FL - 1/1/2006
• Update on ALPS 
  CCHMC/UC, Cincinnati, OH, 2006 - 1/1/2006
• Autoimmune Lymphoproliferative Syndrome (ALPS) 
  1/1/2003
• Autoimmune lymphoproliferative syndrome 
  Children's Hospital of Pittsburgh, Pittsburgh PA - 1/1/2003
• The three faces of autoimmune lymphoproliferative syndrome (ALPS) 
  Feinberg School of Medicine at Northwestern University, Children’s Memorial Institute for Education - 1/1/2003
• A tale of two TNFRSF systems 
  1/1/2003
• Primary Immunodeficiency Disorders (PID) in the Family Practice Environment 
  University of Arkansas for Medical Sciences - 1/1/2002
• Live and Let Die” in the Immune System: An Update on Human Disorders of Immunoregulation 
  Memphis TN - 1/1/2002
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Other

• Immunologic lessons learned from patients with autoimmune lymphoproliferative syndrome (Ph.D. Dissertation) 
  Bleesing J, University of Leiden
  Leiden, The Netherlands - 1/1/2002