David Evan Leaf MD MMSc, FASN

Acute Renal Failure, Critical Care, Renal Metabolism

Associate Professor of Medicine, Harvard Medical School; Director of Clinical and Translational Research in Acute Kidney Injury, Division of Renal Medicine, Brigham and Women's Hospital; Associate Editor, Journal of the American Society of Nephrology

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75 Francis StBoston, MA 02115

Summary

I am an academic physician-scientist, clinical nephrologist, full-time faculty member in the Division of Renal Medicine at Brigham and Women’s Hospital, Associate Professor of Medicine at Harvard Medical School, and an Associate Editor of Journal of the American Society of Nephrology. My lab (www.leaflab.org) conducts patient-oriented and translational research in acute kidney injury (AKI), investigating novel risk factors for its development and therapies for its prevention.

Clinical Expertise

Acute renal failure, Sepsis, Calcium, Dysregulated Mineral Metabolism, Phosphates, acute kidney injury

Education & Training

Mass General Brigham/Brigham and Women's Hospital/Massachusetts General HospitalFellowship, Nephrology, 2011 - 2015
Harvard Medical SchoolMMSc, Clinical Research, 2012 - 2014
New York Presbyterian Hospital (Columbia Campus)Residency, Internal Medicine, 2008 - 2011
New York University School of MedicineClass of 2008
University of PennsylvaniaBA, Psychology, 2000 - 2004

Certifications & Licensure

MA State Medical License 2013 - 2025
NY State Medical License 2009 - 2012
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

Best Clinical/Translational Cancer Immunotherapy Paper Award Society for Immunotherapy of Cancer, 2022
Editors' Choice Article (one of the top five original publications in 2020) Journal of the American Society of Nephrology, 2021
Chair's Research Award Brigham and Women's Hospital, Department of Medicine, 2019
Outstanding Reviewer Award Clinical Journal of the American Society of Nephrology, 2018
Chair’s Research Award Brigham and Women's Hospital, Department of Medicine, 2015
Teaching Award for Excellence as a Tutorial Leader Harvard Medical School, 2013-2014
Excellence in Research New York Presbyterian Hospital, Columbia Campus, 2011
Andrew Alan Friedland Memorial Award for Excellence in Internal Medicine NYU School of Medicine, 2008
Honors in Physiology and Neuroscience Basic Science Research NYU School of Medicine, 2008
Phi Beta Kappa University of Pennsylvania, 2004
Summa Cum Laude University of Pennsylvania, 2004
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Clinical Trials

Vitamin D Repletion in Stone Formers With Hypercalciuria Start of enrollment: 2010 Sep 01
Completed
Phase 4
Randomized Controlled Trial of Calcitriol vs. Placebo Among Critically-ill Patients With Sepsis Start of enrollment: 2013 Feb 01
Completed
Phase 2
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury Start of enrollment: 2017 Apr 03
Completed
Phase 2
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury Start of enrollment: 2021 Apr 13
COMPLETED
PHASE2
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Publications & Presentations

PubMed

Improving Processes of Care after Acute Kidney Injury.
L Parker Gregg, David E Leaf
Journal of the American Society of Nephrology. 2025-03-01
Another Win for SGLT2 Inhibitors in Chronic Kidney Disease.
David E Leaf, Nisha Bansal
The New England Journal of Medicine. 2025-02-20
Effect of mannitol on cisplatin-associated acute kidney injury: a target trial emulation.
Shruti Gupta, Ilya G Glezerman, Jamie S Hirsch, Sophia L Wells, Kevin L Chen
Nephrology, Dialysis, Transplantation. 2025-02-04

Lectures

To Treat or Not to Treat: Medication Toxicity and Clinical Conundrums
American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/7/2019
Intradialytic Hypertension
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Left ventricular assist devices and renal function
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Rhabdomyolysis-induced acute kidney injury
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Mechanisms of hypokalemia induced by therapeutic hypothermia
Grand Rounds, Division of Nephrology, Brigham & Women's Hospital and Massachusetts General Hospital
Relationship between ICU design and mortality
Grand Rounds, Department of Medicine, New York Presbyterian Hospital, Columbia Campus
Mechanisms of action of acetazolamide in the treatment and prophylaxis of acute mountain sickness
Grand Rounds, Division of Nephrology, NYU Medical Center
Chess, Education, and Intelligence
Grand Rounds, Department of Psychiatry, NYU Medical Center
Effect of Vitamin D Repletion on Urinary Calcium Excretion among Stone Formers
Selected Oral Presentation, American Society of Nephrology, Kidney Week, Philadelphia
Effect of Vitamin D Repletion on Urinary Calcium Excretion among Stone Formers
Invited oral presentation, Research of Calculus Kinetics (R.O.C.K.) Society, Boston
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Press Mentions

Glucarpidase improves recovery after chemotherapy-induced kidney toxicityJanuary 23rd, 2025
Can Glucarpidase Help Reverse Methotrexate Kidney Damage?January 9th, 2025
Glucarpidase Improves Outcomes in Methotrexate-Associated AKIJanuary 6th, 2025
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Grant Support

Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery BypassBRIGHAM AND WOMEN'S HOSPITAL2024–2029
Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery BypassNIH/NIA2024–2029
Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney InjuryBRIGHAM AND WOMEN'S HOSPITAL2022–2026
Deferoxamine for the Prevention of Acute Kidney InjuryBRIGHAM AND WOMEN'S HOSPITAL2020–2025
Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessNIH/NHLBI2019–2023
Dysregulated Mineral Metabolism and Acute Kidney InjuryNIH/NIDDK2015–2020
Hepcidin, Dysregulated Iron Homeostasis, and Anemia in Human Acute Kidney InjuryASN Foundation for Kidney Research Carl W. Gottschalk Research Scholar Grant2018–2019
Dysregulated Mineral Metabolism in Critically Ill Patients with Severe AKINIH/NIDDK2015–2017
Dysregulated Mineral Metabolism in Acute Kidney InjuryNIH/NIDDK2013–2015