DanielS.ChenMDPhD

Oncology • Burlingame, CA

Melanoma

Founder and CEO, Synthetic Design Lab, Inc Founder, Engenuity Life Sciences

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Office
Synthetic Design Lab
Burlingame, CA 94010

Summary

Cancer Immunotherapy, PD-L1, PD-1, Immunology, Drug Development, Biomarkers, Angiogenesis, Molecular Diagnostics, Biochips, Virology, Targeted Therapy, Melanoma Oncology
Specialties: Drug Development, Molecular Diagnostics, Translational Research
Medical Oncologist and Cancer Immunologist.

Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Medical Oncology, 2000 - 2003
Stanford Health Care-Sponsored Stanford UniversityResidency, Internal Medicine, 1998 - 2000
Keck School of Medicine of the University of Southern CaliforniaClass of 1998
Massachusetts Institute of TechnologyBS, Biology, 1986 - 1990

Certifications & Licensure

CA State Medical License 1999 - 2024

Awards, Honors, & Recognition

https://www.pinterest.com/dschen5/dsc/

Clinical Trials

Carboplatin Plus Etoposide With or Without MPDL3280A in Untreated Extensive Stage Small Cell Lung Cancer Start of enrollment: 2016 Mar 01
Terminated
Phase 1, Phase 2
Atezolizumab and Bevacizumab in Treating Patients with Rare Solid Tumors Start of enrollment: 2017 Mar 03
ACTIVE_NOT_RECRUITING
PHASE2
A Study of Imvotamab Monotherapy and in Combination in Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma Start of enrollment: 2019 Sep 30
TERMINATED
PHASE1, PHASE2
Atezolizumab Plus Bevacizumab in First Line NSCLC Patients Start of enrollment: 2019 May 15
COMPLETED
PHASE2
An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C) Start of enrollment: 2021 Dec 01
ACTIVE_NOT_RECRUITING
PHASE3
Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis Start of enrollment: 2018 Jul 07
COMPLETED
PHASE2
Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants With Relapsed, Refractory, or Newly Diagnosed Cancers Start of enrollment: 2020 Sep 23
ACTIVE_NOT_RECRUITING
PHASE1
Evaluation of IGM-6268 in Healthy Adults and Patients With Mild to Moderate COVID-19 Start of enrollment: 2022 Jan 20
Terminated
Phase 1
Evaluation of IGM-6268 in Healthy Volunteers Start of enrollment: 2021 Dec 07
Terminated
Phase 1
Neoadjuvant Atezolizumab in Cutaneous Melanoma Start of enrollment: 2020 Sep 25
ACTIVE_NOT_RECRUITING
PHASE1
89Zr-atezolizumab PET Scan and Lobular Breast Cancer Start of enrollment: 2019 Dec 18
Terminated
Not Applicable
"neoBREASTIM": Atezolizumab Plus RP1 Oncolytic Immunotherapy in the NeoAdjuvant Setting of Triple-Negative Breast Cancer Start of enrollment: 2024 Apr 05
Recruiting
Phase 1, Phase 2
A Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab Compared With Intravenous Atezolizumab Formulation in Participants With Non-Small Cell Lung Cancer Start of enrollment: 2022 Apr 04
COMPLETED
PHASE2
A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial Start of enrollment: 2024 Mar 21
RECRUITING
PHASE2
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing Start of enrollment: 2025 Mar 25
RECRUITING
PHASE1
A Study of Atezolizumab in High PD-L1 Expression, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Squamous Non-Small Cell Lung Cancer Start of enrollment: 2022 Jun 14
RECRUITING
PHASE3
Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC Start of enrollment: 2023 Dec 07
RECRUITING
PHASE2
Atezolizumab Plus Bevacizumab Alone or Combined with External Beam Radiotherapy for HCC with Macrovascular Invasion Start of enrollment: 2022 Oct 22
RECRUITING
PHASE2
Predictive Biomarkers in Patients With Advanced Hepatocellular Carcinoma Treated With Atezolizumab Plus Bevacizumab Start of enrollment: 2021 Aug 02
Recruiting
TACE Plus Atezolizumab/Bevacizumab and I-125 Seeds Brachytherapy for HCC With Branch PVTT Start of enrollment: 2023 Aug 30
RECRUITING
NA
Evaluation of IGM-2644 in Adults With Relapsed and/or Refractory Multiple Myeloma Start of enrollment: 2023 Aug 29
TERMINATED
PHASE1
Evaluation of IGM-7354 in Adults With Relapsed and/or Refractory Cancer Start of enrollment: 2023 Jan 10
COMPLETED
PHASE1
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Publications & Presentations

PubMed

Immunity as biophysics at the surface of a T cell.
Daniel S Chen
Immunity. 2024-02-13
235 citations
The cancer-immunity cycle: Indication, genotype, and immunotype.
Ira Mellman, Daniel S Chen, Thomas Powles, Shannon J Turley
Immunity. 2023-10-10
10 citations
Maximizing the value of phase III trials in immuno-oncology: A checklist from the Society for Immunotherapy of Cancer (SITC).
Michael B Atkins, Hamzah Abu-Sbeih, Paolo A Ascierto, Michael R Bishop, Daniel S Chen
Journal for Immunotherapy of Cancer. 2022-09-01

Journal Articles

Differential Regulation of PD-L1 Expression by Immune and Tumor Cells in NSCLC and the Response to Treatment with Atezolizumab (Anti–PD-L1)
Alan Sandler, David S Shames, Hartmut Koeppen, Jamie Chaft, Scott N Gettinger, Alexander Spira, Daniel S Chen, Naiyer A Rizvi, David R Spigel, Proceedings of the National Academy of Sciences
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
Fehrenbacher, L, Spira, A, Ballinger, M, Kowanetz, M, Vansteenkiste, J, Mazieres, J, Park, K, Smith, D, Artal-Cortes, A, Lewanski, C, Braiteh, F, Waterkamp, D, He, P, ..., Lancet, 1/1/2016

Abstracts/Posters

High Avidity IgM-Based CD20xCD3 Bispecific Antibody (IGM-2323) for Enhanced T-Cell Dependent Killing with Minimal Cytokine Release
Daniel Chen, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019

Press Mentions

Too Many Trials, Not Enough PatientsNovember 18th, 2019
Drug Giant Tries New Tactic to Fight CancerMay 27th, 2019
A Cure for Cancer: How to Kill a KillerNovember 4th, 2018
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Committees

Co-Organizer, SITC Immuno Engineering Initiative 2022 - Present
co-organizer, SITC Deep Dive Series 2020 - Present
Board of Directors, SITC (Society of Immunotherapy for Cancer) 2018 - 2022
Co-Chair, CRI Cancer Immunotherapy Consortium 2016 - 2020
Committee Chair, Society for Immunotherapy of Cancer 2012 - 2018

Professional Memberships

American Society of Clinical Oncology - ASCO
Member
American Association for Cancer Research - AACR
Member
American Society of Hematology - ASH
Member

Other Languages

Chinese (Mandarin)

Industry Relationships

Founder, Bionic Cell Medicines2022 - Present
Founder and CEO, Synthetic Design Lab2022 - Present
Founder, Engenuity Life Sciences2022 - Present
Chief Medical Officer, IGM Biosciences2018 - Present
Vice President, Global Head for Cancer Immunotherapy, Genentech/Roche2006 - 2018