CynthiaJWetmoreMDPhD

PubMed

• 25 citations
  Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma
  Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas
  Nature Communications. 2021-07-02
• 18 citations
  A phase 1 study of prexasertib (LY2606368), a CHK1/2 inhibitor, in pediatric patients with recurrent or refractory solid tumors, including CNS tumors: A report from th...
  Thomas Cash, Elizabeth Fox, Xiaowei Liu, Charles G. Minard, Joel M. Reid
  Pediatric Blood & Cancer. 2021-04-21
• 2 citations
  Population Pharmacokinetics of Sunitinib and its Active Metabolite SU012662 in Pediatric Patients with Gastrointestinal Stromal Tumors or Other Solid Tumors.
  Erjian Wang, Steven G. DuBois, Cynthia Wetmore, Arnauld Verschuur, Reza Khosravan
  European Journal of Drug Metabolism and Pharmacokinetics. 2021-04-14

Journal Articles

• Phase I trial, pharmacokinetics and pharmacodynamics of vandetanib and dasatanib in children with newly diagnosed diffuse intrinsic pontine glioma  
  Broniscer A, Baker SD, Wetmore C, Pai-Panandiker A, Huang J, Davidoff AM, Onar-Thomas A, Panetta JC, Chin TK, Merchant TE, Baker JN, Kaste SC, Gajjar A, Stewart CF, Clin Cancer Res, 1/27/2013
• Determination of crenolanib in human serum and cerebrospinal fluid by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS)  
  Roberts MS, Turner DC, Owens TS, Ramachandran A, Wetmore C, Throm SL, Stewart CF, J Chromatogr B Analyt Technol Biomed Life Sci, 1/15/2013
• Diffuse leptomemingeal gliomatosis  
  Jicha GA, Glantz J, Clarke MJ, Lehwald LM Russo DP, Giannini C, Wald JT, Uhm J, Kumar N, Aksamit AJ, Wetmore CJ, Eur Neurol, 1/1/2009
• Gli1-induces G2/M arrest in normal but not tumor-derived neural stem cells  
  Galvin KE, Ye H, Erstad DJ, Feddersen R, Wetmore C, Stem Cells, 1/1/2008
• A molecular fingerprint for medulloblastoma  
  Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel M, Curran T, Gilbertson R, McKinnon PJ, Cancer Res, 1/1/2003
• Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma  
  Yang WQ, Senger D, Muzik H, Shi ZQ, Brasher PMA, Newcastle MB, Hamilton M, Wolff J, Wetmore C, Curran T, Lee PWK, Forsyth PA, Cancer Res, 1/1/2003
• Mouse embryos cloned from brain tumors  
  Li L, Connelly MC, Wetmore C, Curran T, Morgan JI, Cancer Res, 1/1/2003
• Prediction of central nervous system embryonal tumor outcome based on gene expression  
  Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JYH, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Bie..., Nature, 1/1/2002
• Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum  
  Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey A, Roberts T, VanDyke T, Wetmore C, Chiu I, Giovannini M, Guha A, Higgins R, Marino S, ..., Oncogene, 1/1/2002
• ERBB Receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease  
  Gilbertson RJ, Bentley L, Hernan R, Junttila TT, Frant AJ, Haapasalo H, Connelly M, Wetmore C, Curran T, Elenius K, Ellison DW, Clin Cancer Res, 1/1/2002
• Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched  
  Wetmore C, Eberhart DE, Curran T, Cancer Res, 1/1/2001
• The normal patched allele is expressed in medulloblastomas from mice with heterozygous germline mutation of patched  
  Wetmore C, Eberhart DE, Curran T, Cancer Res, 1/1/2000
• Cellular hybridization for BDNF, trkB and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus  
  Schmidt-Kastner R, Wetmore C, Olson L, Neuroscience, 1/1/1996
• Cellular hybridization for BDNF, trkB and NGF mRNAs and BDNF-immunoreactivity in rat forebrain after pilocarpine-induced status epilepticus  
  Schmidt-Kastner R, Humpel C, Wetmore C, Olson L, Exp Brain Res, 1/1/1996
• Neuronal and non-neuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia of rat suggest new intercellular trophic interactions  
  Wetmore C, Olson L, J Comp Neurol, 1/1/1995
• Structural correlates and cellular mechanisms in entorhinal-hippocampal dysfunction  
  Schousboe A, Bachevalier J, Braak H, Heinemann U, Nitsch R, Schroder H, Wetmore C, Hippocampus, 1/1/1993
• Initial studies of embryonic transplants of human hippocampus and cerebral cortex derived from schizophrenic women  
  Freedman R, Strömberg I, Seiger A, Olson L, Nordstrom AL, Wiesel FA, Bygdeman M, Wetmore C, Palmer MR, Hoffer BJ, Biol Psychiatr, 1/1/1992
• High and low-affinity NGF receptor mRNAs in human foetal spinal cord and ganglia  
  Wetmore C, Bygdeman M, Olson L, Neuroreport, 1/1/1992
• Brain-derived neurotrophic factor: Subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies  
  Wetmore C, Cao Y, Pettersson R, Olson L, Proc Natl Acad Sci, 1/1/1991
• The nerve growth factor gene is expressed in both neuronal and non-neuronal tissues in the human embryo  
  Ernfors P, Wetmore C, Eriksdotter-Nilsson M, Bygdeman M, Strö'mberg I, Wetmore C, Olson L, Persson H, Int J Dev Neurosci, 1/1/1991
• Detection and characterization of sensory microganglion associated with the spinal accessory nerve  
  Wetmore C, Elde R, J Comp Neurol, 1/1/1991
• Rescue of forebrain cholinergic neurons after implantation of genetically modified cells producing recombinant NGF  
  Strömberg I, Wetmore CJ, Ebendal T, Ernfors P, Persson H, Olson L, J Neurosci Res, 1/1/1990
• Grafts, growth factors and grafts that make growth factors In: Neural Transplantation: From Molecular Bases to Clinical Application  
  Olson L, Ayer-LeLievre C, Ebendal T, Eriksdotter-Nilsson M, Ernfors P, Henschen A, Hoffer B, Giacobini MB, Mouton P, Palmer M, Persson H, Sara V, Strömberg I, Wetmore C, Prog Brain Res, 1/1/1990
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Books/Book Chapters

• Determined to Matter 
  Chapter: Book Afterward 
  O'Hara JHScarletta Press2013
• Principles & Practice of Neuro-oncology 
  Chapter: Brain tumor predisposition syndromes. 
  Foy AB, Wetmore CEditors: M. Mehta, et al.Demos Medical Publishing2010
• Principles of Neuro-oncology 
  Chapter: "The Phakomatoses" 
  Gutmann DH, Wetmore C, O'Neill BPEditors: David Schiff and Brian Patrick O'Neill.McGraw-Hill2005
• Research and Perspectives in Alzheimer's Disease 
  Chapter: Localizing expression of the three members of the NGF family to neurons in the brain. 
  Olson L, Wetmore C, Ernfors P, Ebendal T, Persson HEditors: Christen Y.Foundation EPSEN/Springer-Verlag1991
• Wenner-Gren Symposium "Volume Transmission." 
  Chapter: Endogenous and exogenous nerve growth factor in the central nervous system. 
  Olson L, Wetmore C, Strömberg I, Ebendal TEditors: Fuxe K.Raven Press1991
• Brain Repair, Wenner-Gren International Symposium Series. 
  Chapter: Strategies to increase NGF levels and effects thereof on lesioned and grafted brain tissue. 
  Page 87 - 98Olson L, Ebendal T, Eriksdotter-Nilsson M, Ernfors P, Friedman W, Persson H, Wetmore C, Strömberg IEditors: Björklund A, Aguayo A, Ottoson D.Macmillan, London, UK1990
• Growth Factors – From Genes to Clinical Application 
  Chapter: The expanding role of nerve growth factor in the central nervous system. 
  Page 167 - 177Olson L, Henschen A, Eriksdotter-Nilsson M, Str`mberg I, Wetmore C, Ernfors P, Friedman W, Persson H, Ebendal TEditors: Sara V, Hall K.Raven Press, New York, NY1990
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Abstracts/Posters

• First in Pediatrics Phase I study of crenolanib (CP-868,596) administered during and after radiation therapy (RT) in newly-diagnosed diffuse intrinsic pontine glioma (...
  Wetmore, C., Broniscer, A., Wright, K., Armstrong, G., Baker, J., Kun, L., Patay, Z., Onar-Thomas, A., Ramachandran, A., Turner, D., Gajjar, A., Stewart, C, ASCO Annual Meeting, Chicago, IL, 1/1/2014
• Activity of alisertib (MLN8237) as single agent in recurrent atypical teratiod tumor (ATRT) in four children: a single patient treatment plan pilot study.
  Wetmore C, Bendel A, Gajjar A, Rhabdoid Tumors: Integrating biological insights with clinical successes. Institut Curie, Paris, France, 1/1/2013
• A Phase I trial of MK-0752 in Pediatric Patients with Recurrent or Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study.
  M. Fouladi, J. Olson, C.F. Stewart, M. Kocak, A. Onar-Thomas, L. Wagner, R. J. Packer, S. Goldman, S. Gururangan, S. M. Blaney, I. Pollack, C. Smith, A. Gajjar, T. Dem..., SNO Annual Meeting, 1/1/2013
• Phase I study of crenolanib (CP-868,596) administered during and after radiation therapy (RT) in newly-diagnosed diffuse intrinsic pontine glioma (DIPG) and recurrent ...
  Wetmore, C., Broniscer, A., Wright, K., Armstrong, G., Baker, J., Pai-Panandiker, A., Kun, L., Patay, Z., Onar-Thomas, A., Ramachandran, A., Turner, D., Gajjar, A., S..., AACR-NCI-EORTC, Dublin, Ireland, 1/1/2012
• Phase I study of crenolanib (CP-868,596) administered during and after radiation therapy (RT) in newly-diagnosed diffuse intrinsic pontine glioma (DIPG) and recurrent ...
  C Wetmore, A Broniscer, K Wright, G Armstrong, J Baker, A Pai-Panandiker, L Kun, Z Patay, A Onar-Thomas, A Ramachandran, D Turner, A Gajjar, C Stewart, ISPNO, Toronto, Canada, 1/1/2012
• Therapeutic doses of ionizing radiation damage the neural stem cell niche and impair hippocampal-dependent learning in the young mouse.
  Nageswara Rao, A.A., Howe, C., Ye, H., Choi, D.S., Wetmore, C, Society for Neuroscience Annual Meeting, 1/1/2009
• P53 independent abrogation of G1 arrest in tumor-derived neural stem like cells after exposure to ionizing radiation.
  Foy, A.B, Ye, H., Wetmore, C, World Federation of Neuro-Oncology, Yokohama, Japan, 1/1/2009
• Pleomorphic Xanthoastrocytoma: A single institutional experience and review of literature.
  Nageswara Rao, A., Laack, N., Giannini, C, Wetmore, C, American Society for Pediatric Hematology/Oncology Annual meeting, 1/1/2009
• Tumor stem cells abrogate G1 arrest after ionizing radiation.
  Foy, A.B., Ye, H., Wetmore, C, AANS, San Diego, CA, 1/1/2009
• Mitotane Therapy for Intradural Spinal Adrenocortical Tumor in an Infant.
  Remberto C. Paulo, Vilmarie Rodriguez, Aida N. Lteif, Wetmore, C, Pediatric Academic Societies Annual meeting, 1/1/2008
• Abrogation of G1 arrest in murine brain tumor-derived stem like cells after ionizing radiation.
  Foy, A.B., Ye, H., Wetmore, C, AACR Annual meeting, San Diego, CA, 1/1/2008
• Bmi1- independent proliferation of stem cells derived from Hedgehog pathway–initiated medulloblastoma.
  Feddersen, R., Galvin, K.E., Ye, Hong, Wetmore, C, Society for Neuro-oncology Annual Meeting, Dallas, TX, 1/1/2007
• Bmi1- independent proliferation of stem cells derived from Hedgehog pathway –initiated medulloblastoma.
  Feddersen, R., Galvin, K.E., Ye, Hong, Wetmore, C, International Society of Pediatric Oncology (SIOP) Annual meeting, Mumbai, India, 1/1/2007
• Modulation of Sonic hedgehog signaling in normal and tumor-derived neural stem cells.
  Galvin, K.E., Ye, H., Wetmore, C, EMBO Shh Workshop, Rome, Italy, 1/1/2006
• Is Gli1 required for neural stem cell proliferation?
  Galvin, K.E., Ye, H., Wetmore, C, Society for Neuroscience Annual Meeting 2006, Atlanta, GA, 1/1/2006
• Modulation of Sonic hedgehog signaling in normal and tumor-derived neural stem cells.
  Galvin, K.E., Ye, H., Wetmore, C, Keystone Symposium "Cancer, stem cells and senescence", Singapore, Singapore, 1/1/2005
• Cellular and molecular consequences of Patched haploinsufficiency: analysis of differential gene expression during proliferation and differentiation of cerebellum.
  Leonard, JM, Baskerville, K., Ye, H., McKinney, M., Wetmore, C, Society for Neuroscience Annual Meeting, San Diego, CA, 1/1/2004
• Increased proliferation of neural progenitor cells in mice haploinsufficient for the Sonic hedgehog receptor, Patched*.
  Galvin, KE. Ye, Hong, Wetmore, C, Society for Neuroscience Annual Meeting, San Diego, CA, 1/1/2004
• Loss of p53 but not ARF or ATM accelerates medulloblastoma formation in mice heterozygous for patched.
  Wetmore, C., Eberhart, D., Curran, T, Platform presentation, American Association for Cancer Research Annual Meeting, New Orleans, LA, 1/1/2001
• Molecular analysis of brain tumors arising in mice heterozygous for patched mutations: a model for medulloblastoma.
  Wetmore, C., Curran, T, International Society for Pediatric Neuro-oncology, San Francisco, CA, 1/1/2000
• Accelerated central nervous system tumorigenesis in mice with mutations in both patched and p53 genes.
  Wetmore, C., Curran, T, AACR Annual Meeting, San Francisco, CA, 1/1/2000
• Molecular and histologic analysis of brain tumors in mice heterozygous for patched mutations: a model for medulloblastoma.
  Wetmore, C., Curran, T, Platform presentation, Society for Neuro-Oncology Annual Meeting, Scottsdale, AZ, 1/1/1999
• Tumorigenesis in mice heterozygous for patched mutations.
  Wetmore, C. Curran, T, AACR Annual Meeting, Philadelphia, PA, 1/1/1999
• Neurotrophin-3 immunoreactive nerve fibers innervate villi and blood vessels in rodent small intestine.
  Wetmore C, Vulchanova L, Olson L, US Society for Neuroscience Annual Meeting, 1/1/1995
• Kainate receptor mediated differential regulation of brain-derived neurotrophic factor mRNA and protein.
  Wetmore C, Bean AJ, Olson L, US Society for Neuroscience Annual Meeting, 1/1/1992
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Lectures

• Research 101: Tissue acquisition and Bio-banking. 
  1/1/2014
• The Cancer Answer: Progress and Possibilities 
  Woodruff Arts Center, Atlanta, GA - 1/1/2014
• PDGFR signaling in diffuse pontine glioma. 
  Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY - 1/1/2013
• Bridging the Gap: Translating basic research into new approaches in clinical care. 
  Portsmouth, UK - 1/1/2013
• Venous Thrombosis in Pediatric Brain Tumor Patients. 
  1/1/2011
• DIPG: understanding heterogeneity in clinical presentation, biology and outcome. 
  1/1/2011
• Mechanism and consequences of Shh pathway activation in response to ionizing radiation. 
  Toronto Hospital for Sick Children - 1/1/2010
• Pediatric Brain Tumor Management. 
  Vietnam - 1/1/2010
• Oncologic Emergencies. 
  Vietnam - 1/1/2010
• Cell-type specific Hedgehog signaling in neural progenitor cells. 
  1/1/2009
• Neurogenesis and cancer therapy: can we spare neural progenitor cells without sparing the tumor? 
  Mayo Clinic, Rochester, MN - 1/1/2009
• Hedgehog signaling in normal and neoplastic neural progenitor cells. 
  Karolinska Institute, Stockholm, Sweden - 1/1/2008
• Preserving neurogenesis in survivors of pediatric cancer. 
  Memorial Sloan Kettering Cancer Center - 1/1/2008
• Molecular control of neural progenitor cell proliferation. 
  Rochester, MN - 1/1/2008
• Molecular mechanisms of pediatric brain tumorigenesis. 
  Rochester, MN - 1/1/2007
• MD, PhD or MD, PhD: To be or not to be? 
  Mayo Graduate School, Rochester, MN, 2004, 2007 - 1/1/2007
• Modulation of Hedgehog signaling in normal and neoplastic neural stem cells. 
  Rochester, MN - 1/1/2007
• Hedgehog signaling in normal and neoplastic stem cells. 
  Dallas, TX - 1/1/2007
• Differential transduction of Sonic Hedgehog signaling in neural progenitor cells 
  New York, NY - 1/1/2007
• Hedgehog signaling in cancer and stem cells. 
  Rome, Italy - 1/1/2006
• Cell-type specific modulation of Hedgehog signaling: dysregulation in medulloblatoma. 
  M.D. Anderson Cancer Center, Houston, TX - 1/1/2006
• Molecular aberrations in pediatric brain tumors 
  Bethesda, MD - 1/1/2006
• Differential transduction of Hedgehog signaling in tumor stem cells. 
  University of Minnesota, Minneapolis, MN - 1/1/2006
• Molecular basis of pediatric brain tumors 
  Rome, Italy - 1/1/2005
• Dysregulation of Sonic hedgehog signaling in neural progenitor cells. 
  Children's National Medical Center, Washington, DC - 1/1/2005
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