CharlesLeVeaMD

PubMed

• 130 citations
  Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation.
  Xiaolan Qian, Charles LeVea, Jon Freeman, William C. Dougall, Mark I. Greene
  Proceedings of the National Academy of Sciences of the United States of America. 1994-02-15
• 58 citations
  Lymphovascular and perineural invasion are associated with poor prognostic features and outcomes in colorectal cancer: A retrospective cohort study.
  Eisar Al-Sukhni, Kristopher Attwood, Emmanuel Gabriel, Charles LeVea, Kazunori Kanehira
  International Journal of Surgery. 2017-01-01
• 37 citations
  A newly recognized entity: intraductal “oncocytic” papillary neoplasm of the pancreas
  S Jyotheeswaran, G Zotalis, P Penmetsa, Charles LeVea, Luke O. Schoeniger
  The American Journal of Gastroenterology. 1998-12-01

Journal Articles

• Modulating Gut Immunity and Neoplasia with Oral Cytokine Adjuvants  
  Hatice Ozbilge, Charles LeVea, Allen Y Chung, Qingsheng Li, and Nejat K Egilmez, OncoImmunology, 1/1/2015
• Schwannoma of the seminal vesicle in a patient with rectal cancer  
  Jared Rocky Funston, Charles LeVea, Ashwani Rajput, Case Reports in Clinical Pathology, 1/1/2015
• Outcomes of Endoscopic Resection for High-Grade Dysplasia and Esophageal Cancer  
  Nurkin Steven J; Nava Hector R; Yendamuri Sai; LeVea Charles M; Nwogu Chumy E; Groman Adrienne; Wilding Gregory; Bain Andrew J; Hochwald Steven N; Khushalani Nikhil I, Surgical Endoscopy, 1/1/2014
• An ectopic biliary calculus mimicking gastric neoplasm: A late complication of spilled gallstones  
  Raed M. Alnaji, Moshim Kukar, Amanpal Singh, Charles M. LeVea, Steven N. Hochwald, Surgery, 1/1/2014
• Breast Cancer Resistance Protein (BCRP) and excision repair cross complement-1 (ERCC1) expression in esophageal cancers and response to Cisplatin and Irinotecan based ...  
  Sana Saif Ur Rehman, Jennifer Black, Charles LeVea, Usha Malhotra, and Renuka Iyer, J Gastrointest Oncol, 1/1/2014
• Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells  
  Chu, Allen, Qingsheng Li, Sarah J. Blair, et al, Cancer Res, 1/1/2014
• Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models  
  H Zhang, B L Hylander, C LeVea, E A Repasky, R M Straubinger, A A Adjei and W W Ma, British Journal of Cancer, 1/1/2014
• Erlotinib and Radiation Therapy for Elderly Patients with Esophageal Cancer - Clinical and Correlative Results from a Prospective Multicenter Phase 2 Trial  
  Iyer R. Chhatrala R. Shefter T. Yang G. Malhotra U. Tan W. LeVea C. Robins M. Khushalani N, Oncology, 1/1/2013
• Neoadjuvant chemoradiotherapy for esophageal/gastroesophageal carcinoma  
  Timothy A. Platz, Steven J. Nurkin, Mei Ka Fong, Adrienne Groman, Leayn Flaherty, Usha Malhotra, Charles M. LeVea, Sai Yendamuri, Graham W. Warren, Hector R. Nava, Kil..., Journal of Gastrointestinal Oncology, 1/1/2013
• The Advances in Molecular Biology of Hepatoblastoma: Implications for Diagnostic Pathology  
  Weiwei Chen, MD, PhD; Rafal Kozielski, MD; Charles LeVea, MD, PhD; Frank Chen, MD, PhD, N A J Med Sci, 1/1/2012
• Nephrogenic Adenoma of the Urinary Tract: A Review  
  Alexiev, B. A, and LeVea, C. M, Int J Surg Pathol., 1/1/2012
• Secondary Tumors of the Pancreas: Case Report and a Single-Center Experience  
  Dewanwala, A; Kotowski, A; LeVea, C. M; and Ma, W. W, J Gastrointest Canc, 1/10/2011
• The characterization of PI3K mutations in an orthotopic model of colon cancer  
  Melanie Ongchin, MD, Elizabeth Sharratt, BS, LVT, Ivan Dominguez, MD, Jing Wang, PhD, Charles LeVea, MD, PhD, Michael Brattain, PhD, Ashwani Rajput, MD, FACS, Journal of the American College of Surgeons, 1/1/2009
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  M. Ongchin, E. Sharratt, I. Dominguez, C. LeVea, R. Cheney, J. Wang, M. Brattain, A. Rajput, J Surg Res, 1/1/2009
• EGFR Activation in Isolation is Insufficient for a Metastatic Phenotype in an Orthotopic Colon Cancer Model  
  I. Dominguez, E. Sharratt, C. LeVea, J. Wang, M. Brattain, A. Rajput, J Surg Res, 1/1/2009
• The effects of epidermal growth factor receptor activation and attenuation of the TGFbeta pathway in an orthotopic model of colon cancer  
  Ongchin M, Sharratt E, Dominguez I, Simms N, Wang J, Cheney R, LeVea C, Brattain M, Rajput A, 1/1/2009
• Knockdown of Ron kinase inhibits mutant PI3 kinase and reduces metastasis in human colon carcinoma  
  Wang J, Rajput A, Kan JL, Rose R, Liu XQ, Kuropatwinski K, Hauser J, Beko A, Dominquez I, Sharratt EA, Brattain L, LeVea C, Sun FL, Keane DM, Gibson NW, Brattain MG, J Biol Chem, 1/1/2009
• Characterization of HCT 116 Human Colon Cancer Cells in an Orthotopic Model  
  Rajput A, Dominguez I, Rose R, Beko A, LeVea C, Sharratt E, Mazurchuk R, Brattain MG, Wang J, J Surg Res, 1/1/2008
• Cytokeratin Staining to Detect Residual Disease in Patients Undergoing Neoadjuvant Chemoradiation followed by Esophagectomy for Locally Advanced Esophageal Cancer  
  M. K. Chadha, C. M. LeVea, T. Mashtare, G. Wilding, M. M. Javle & C. E. Nwogu, Internet Journal of Oncology, 1/1/2008
• Phase II Study of Weekly Intravenous Oxaliplatin Combined With Oral Daily Capecitabine and Radiotherapy With Biologic Correlates in Neoadjuvant Treatment of Rectal Ade...  
  Marwan G. Fakih , Kelli BullardDunn, Gary Y. Yang, Lakshmi Pendyala, Karoly Toth, Chris Andrews, Youcef M.Rustum, Mary Ellen Ross, Charles LeVea, Ajithkumar Puthillath..., International Journal of Radiation Oncology, Biology, Physics, 1/1/2008
• Pilot study of Gefitinib, Oxaliplatin, and radiotherapy for esophageal adenocarcinoma: Tissue effect predicts clinical response  
  Milind Javle, MD; Amitkumar Pande, MD; Renuka Iyer, MD; Gary Yang, MD; Charles LeVea, MD, PhD; Gregory Wilding, PhD; Jennifer Black, PhD; Hector Nava, MD; Chukwumere N..., American Journal of Clinical Oncology, 1/1/2008
• Epidermal Growth Factor Receptor (EGFR) Directed Therapy in Esophageal Cancer  
  A.U. Pande, MD; R.V.Iyer; A. Rani MD; S. Maddipatla MD; G.Y. Yang, MD; C.E. Nwogu, MD; J.D. Black PhD; C. M. LeVea M.D., Ph.D, M.M. Javle MD., Oncology, 1/1/2007
• Characterization of two human isogenic colon cancer subclones in an orthotopic model  
  I. Dominguez, R. Rose, C. LeVea, E. Sharratt, K. Bullard Dunn, M. Brattain, A. Rajput, J Surg Res, 1/1/2007
• Mutant PIK3CA bearing colon cancer cells display increased metastasis in an orthotopic model  
  Guo X, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, LeVea C, Hoffman RM, Brattain MG, Wang J, Cancer Res, 1/1/2007
• CD-24 Expression is an Independent Prognostic Marker in Cholangiocarcinoma  
  Agrawal, S., Khoury, T., LeVea, C., Gibbs, J., J Gastrointest Surg, 1/1/2007
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Books/Book Chapters

• Minimally Invasive Foregut Surgery for Malignancy 
  Chapter: Pathogenesis of Esophageal Cancer. Chapter 1 
  LeVea, Charles M. M.D., Ph.D.Editors: Steven Hochwald, Moshim Kukar.Springer International Publishing, Switzerland2015

Abstracts/Posters

• Synoptic Reports Improve Completeness of Pathologic Reporting For Appendiceal Mucinous Neoplasms.
  Al-Sukhni, Eisar; LeVea, Charles; Skitzki, Joseph; Kane, John; and Francescutti, Valerie, Society of Surgical Oncology, 1/1/2016
• Diagnosis of Appendiceal Mucinous Neoplasms: Variability Among Pathologists And Impact On Clinical Course.
  Al-Sukhni, Eisar; LeVea, Charles; Skitzki, Joseph; Kane, John; and Francescutti, Valerie, Society of Surgical Oncology, 1/1/2016
• A phase Ib study of FGFR/VEGFR inhibitor dovitinib (D) combined with gemcitabine (G) and capecitabine (C) in advanced pancreatic cancer patients
  Wen Wee Ma, Gerald Fetterly, Charles LeVea, Yujie Zhao, Grace K Dy, Renuka Iyer, Wei Tan, William Brady, Amy Whitworth, Alex A Adjei, European Society for Medical Oncology, 1/1/2016
• Reappraisal of Subserosal Invasion in Patients with pT3 Colorectal Cancer by Elastic Stain: Clinicopathologic Study of 129 Surgical Cases with Special Reference to Per...
  Yukihiro Nakanishi MD, Charles LeVea MD, Shiva Dibaj MS, Fadi Habib MD, Richard Cheney and Kazunori Kanehira MD, USCAP Annual Meeting, 1/1/2015
• A phase Ib study of the FGFR/VEGFR inhibitor dovitinib (D) combined with gemcitabine (G) and Capecitabine (C) in patients with advanced pancreatic and biliary tract ca...
  Wen Wee Ma, Gerald J. Fetterly, Charles LeVea, Yujie Zhao, Grace K. Dy, Renuka V. Iyer, Wei Tan, William E. Brady, Amy Whitworth, Alex A. Adjei, GI ASCO Conference, 1/1/2015
• Utilizing Ki67 score to predict optimal liver directed treatment in patients with metastatic neuroendocrine tumors.
  Singla, Smit; K. Attwood, Kristopher; LeVea, Charles; Hochwald, Steven, GI ASCO & Society of Surgical Oncology, 1/1/2015
• Engraftment of Resected Pancreatic Adenocarcinoma in SCID mice and Patient Survival Following Surgical Resection: Roswell Park’s Experience
  Aranez JL, Jitawatanarat P, Hylander B, Pitoniak R, LeVea C, Repasky ES, and Ma WW, GI ASCO Conference, 1/1/2014
• Inflammation and sexual dimorphism in development of insulin resistance: a dual animal model comparison.
  Zachary A.P. Wintrob, Emmanuel K. Oppong, Yu C. Tse, Hans R. Boateng, Jeffery M. Welt, Michael Martorana, John Irlam, Charles M. LeVea, Silviu L. Faitar, Alice C. Ceac..., Experimental Biology Conference, 1/1/2013
• Outcomes of Endoscopic Resection for High Grade Dysplasia and Esophageal Cancer.
  Hector Nava, MD, Chukwumere Nwogu, MD, Sai Yendamuri, MD, MD, Charles M. LeVea, MD, PhD, Nikhil Khushalani, MD, Digestive Disease Week Meeting & American College of Surgeons' 98th Annual Clinical Congress, 1/1/2012
• Birinapant, a novel Smac mimetic, exerts significant anti-tumor efficacy in primary pancreatic adenocarcinoma model.
  Wen Wee Ma, Hao Zhang, Bonnie L. Hylander, Charles LeVea, Elizabeth A. Repasky, David Weng, Jennifer Burns, Srinivas Chunduru, Martin Graham, Gerald Fetterly, Mark McK..., AACR Meeting, 1/1/2012
• A novel Smac mimetic, exerts significant anti-tumor efficacy in primary pancreatic adenocarcinoma model.
  Wen Wee Ma, Hao Zhang, Bonnie L. Hylander, Charles LeVea, Elizabeth A. Repasky, David Weng, Jennifer Burns, Srinivas Chunduru, Martin Graham, Gerald Fetterly, Mark McK..., 103rd AACR Annual Meeting, 1/1/2012
• Most Metastatic Colorectal Adenocarcinomas Express Less CDX2 than their Primaries.
  Rongjun Guo, Frank Chen, Joyce Paterson, John P. Lynch, Amy Sands, Carl Morrison, Charles LeVea, USCAP Meeting, 1/1/2011
• Phase II multicenter study of erlotinib with radiation therapy (RT) for elderly patients (pts) with esophageal carcinoma (EC): Final report.
  R. R. V. Iyer, G. Yang, T. E. Schefter, W. Tan, H. R. Nava, C. Levea, A. Litwin, M. Robins, N. I. Khushalani, GI ASCO Meeting, 1/1/2011
• Continuous and intermittent Vorinostat in combination with FOLFIRI in advanced upper gastrointestinal cancer: Preliminary results of a phase I pharmacokinetic study.
  Khushalani, Brady, Fetterly, Prey, LeVea, Litwin, Grande, Iyer, Javle, EMSO Meeting, 1/1/2010
• A Phase II study of Erlotinib in patients with advanced pancreatic cancer, who are refractory to Gemcitabine.
  R. V. Iyer, N. I. Khushalani, W. Tan, A. Litwin, P. Starostik, C. LeVea, C. Tucker, W. W. Ma, M. Fakih, A. A. Adjei, GI ASCO Meeting, 1/1/2010
• Phase II multicenter study of Erlotinib with radiation therapy for elderly patients with esophageal carcinoma - final report.
  R. V. Iyer, G. Yang, T. E. Schefter, W. Tan, H. R. Nava, C. LeVea, A. Litwin, M. Robins, N. I. Khushalani, GI ASCO Meeting, 1/1/2010
• Phase II multicenter study of Erlotinib in combination with radiation therapy for elderly patients with esophageal carcinoma - Final report.
  R Iyer, G Yang, T Shefter, W Tan, H Nava, A Litwin, C LeVea, M Robins, N Khushalani, EMSO Meeting, 1/1/2010
• Secondary tumors of the pancreas: Case report and a single center experience.
  Akriti Dewanwala MBBS, Adam Kotowski MD, Charles LeVea MD, PhD, and Wen Ma, MD, Connecticut ACP Chapter Meeting, 1/1/2010
• A Phase II study of Erlotinib in patients with advanced pancreatic cancer, who are refractory to Gemcitabine.
  R. V. Iyer, N. I. Khushalani, W. Tan, A. Litwin, P. Starostik, C. LeVea, C. Tucker, W. W. Ma, M. Fakih, A. A. Adjei, EMSO Meeting, 1/1/2009
• First Reported Case of Primary Clear Cell Sarcoma of Liver: Diagnostic Conundrum
  Chintanaboina, J; LeVea, C; and Iyer, R, Digestive Disease Week, 1/1/2009
• A phase I pharmacokinetic study of vorinostat in combination with irinotecan, 5-fluorouracil and leucovorin (FOLFIRI) in advanced upper gastrointestinal cancers (AGC)
  G. J. Fetterly, W. E. Brady, C. M. LeVea, A. M. Litwin, P. D. Zagst, J. D. Prey, M. Tarquini, M. K. Giardina, R. V. Iyer, N. I. Khushalani, ASCO Annual Meeting, 1/1/2009
• EGFR, p-Erk and p-Akt expression in Barrett’s esophagus (BE): a prospective pilot study.
  Abha Rani, Milind Javle, Charles LeVea, Jihnhee Yu, Michael Brattain, Jennifer Black, Digestive Disease Week, 1/1/2007
• Cytokeratin staining to predict residual disease in patients undergoing neoadjuvant chemoradiation for esophageal cancer.
  M. K. Chadha, P. Lin, M. Javle, R. Iyer, D. Driscoll, H. Nava, G Yang, C. LeVea, ASCO Annual Meeting, 1/1/2007
• Gefitinib (ZD1839) with Oxaliplatin and Radiotherapy for Esophageal Carcinoma.
  Amitkumar Pande, Renuka Iyer, Hector Nava, Gary Yang, Chumy Nwogu, Michael Schiff, Charles LeVea, Jennifer Black, Milind Javle, ASCO Annual Meeting, 1/1/2007
• Characterization of two human isogenic colon cancer subclones in an orthotopic model.
  Dominguez I, Rose R, LeVea C, Sharratt E, Brattain M, Rajput A, Symposium on Advances in Cell Signaling, Cancer Prevention & Therapy, South Padre Island, TX, 1/10/2006
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Lectures

• Making a Treatment Plan: Multidisciplinary Panel 
  Amherst, NY - 1/29/2015
• Colon Morphology and Molecular Biology 
  1/1/2015
• Gastrointestinal Pathology 
  1/1/2015
• PTR 536 Cancer Pathology 
  1/1/2015
• Multidisciplinary Management of NET Cancer 
  Amherst, NY - 1/29/2013
• Multimodality Treatment of Colon Cancer 
  Menorah Medical Center, Overland Park, KS - 1/30/2007
• Core Lecture Series: The diagnosis of pancreatic neoplasms. 
  Buffalo General Hospital, Buffalo, NY - 1/10/2006
• The diagnosis of pancreatic neoplasms. 
  Buffalo General Hospital, Buffalo, NY - 1/16/2004
• The pathology of gastrointestinal stromal tumors. 
  Roswell Park Cancer Institute, Buffalo, NY - 1/6/2004
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