AlexHuangMDPhD

PubMed

• Piezo1 restrains proinflammatory response but is essential in T cell-mediated immunopathology.
  Sung Hee Choi, Alicia Santin, Jay T Myers, Byung-Gyu Kim, Saada Eid
  Journal of Leukocyte Biology. 2024-11-04
• Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity.
  Sung Hee Choi, Jay Thomas Myers, Suzanne Louise Tomchuck, Melissa Bonner, Saada Eid
  Cancer Communications. 2024-08-01
• 1 citations
  Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation.
  Mohammad Alshebremi, Suzanne L Tomchuck, Jay T Myers, Daniel T Kingsley, Saada Eid
  Journal for Immunotherapy of Cancer. 2023-08-01

Journal Articles

• Adoptive Natural Killer cell therapy is effective in reducing pulmonary metastasis of Ewing Sarcoma  
  Tong, A.A., Hashem, H., Eid, S., Huang, A.Y., OncoImmunology, 1/1/2017
• Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands  
  Chung, J., Ebens, C.L., Radojcic, V., Perkey, E., Koch, U., Scarpellino, L., Tong, A., Allen, F., Wood, S., Feng, J., Friedman, A., Granadier, D., Tran, I.T., Chai, Q...., J Clinical Investigation, 1/1/2017
• Cdk5 Disruption attenuates tumor PD-L1 response to IFN leading to CD4+ T-cell mediated rejection  
  Dorand, R.D., Nthale, J., Myers, J.T., Barkauskas, D.S., Chirieleison, S.M., Pareek, T., Abbott, D.W., Stearns, D.S., Letterio, J.J., Huang, A.Y., Petrosiute, A., Science, 1/1/2016
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  Bhaskaran, N., Quigley, C., Weinberg, A., Huang, A., Popkin, D., Pandiyan, P., Mucosal Immunol, 1/1/2016
• Transient surface CCR5 expression by naïve CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response  
  Askew, D., Su, C., Liou, R., Barkauskas, D., Dorand, R.D., Myers, J.T., Nthale, J., Huang, A.Y., J Immunol, 1/1/2016
• Intra-osseous co-transplantation of CD34-selected umbilical cord blood and mesenchymal stromal cells  
  Metheny, L., Eid, S., Lingas, K., Reese, J., Meyerson, H., Tong, A., de Lima, M., Huang, A.Y., Hematology & Medical Oncology, 1/1/2016
• Unique trans-compartmental bridge: Antigen Presenting Cells Sampling Across Endothelial and Mucosal Barriers  
  Allen, F., Tong, A., Huang, A.Y., Frontiers in Immunology, 1/1/2016
• Aberrant Notch signaling in acute lymphoblastic leukemia marrow suppresses osteoblasts and inhibits hematopoietic niche function  
  Wang, W., Zimmerman, G., Huang, X., Myers, J., Wang, Y., Moreton, S., Nthale, J., Awadalla, A., Beck, R., Wald, D., Xin, W., Huang, A.Y., Zhou, L., Cancer Research, 1/1/2016
• Cyclin-dependent Kinase 5 (Cdk5) activity is required for generation of allogeneic T cell responses after hematopoietic cell transplantation in mice  
  Askew, D., Pareek, T., Eid, S., Ganguly, S., Tyler, M., Huang, A.Y., Letterio, J.J., Cooke, K.R., Blood, 1/1/2016
• Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers  
  Shukla, S., Myers, J.T., Woods, S.E., Gong, X., Czapar, A.E., Commandeur, U., Huang, A.Y., Levine, A., Steinmetz, N.F., Biomaterials, 1/1/2016
• Multiple administration of viral nanoparticles alter in vivo behavior - insights from intravital microscopy  
  Shukla, S., Dorand, R.D., Myers, J.T., Woods, S.E., Gulati, N.M., Stewart, P., Commandeur, U., Huang, A.Y., Steinmetz, N.F., ACS Biomaterials Science and Engineering, 1/1/2016
• Cx25 contributes to leukemia cell communication and chemosensitivity  
  Sinyuk, M., Alvarado, A., Nesmiyanov, P., Shaw, J., Mulkerans-Hubert, E.E., Eurich, J.T., Hale, J.S., Bogdanova, A., Hitomi, M., Maciejewski, J., Huang, A.Y., Saunthar..., Oncotarget, 1/1/2015
• Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice  
  Omenetti, S., Brogi, M., Goodman, W.A., Croniger, C.M., Eid, S., Huang, A.Y., Laffi, G., Roskams, T., Cominelli, F., Pinzani, M., Pizarro, T.T., Cellular and Molecular Gastroenterology and Hepatology, 1/1/2015
• Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturation profile  
  Delvecchio, F.R., Vadrucci, E., Cavalcanti, E., De Santis, S., Dale, K., Vacca, M., Myers, J., Allen, F., Bianco, G., Huang, A.Y., Monsurro, V., Santino, A., Chieppa, M., E J Immunol, 1/1/2015
• Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction  
  Barkauskas, D.S., Dorand, R.D., Myers, J.T., Evans, T.A., Barkauskas, K.J., Askew, D.A., Purgert, R., Huang, A.Y., Exp Neurol, 1/1/2015
• Targeting oxidative stress in sickle cell disease with triterpenoid inducers of NRF2 signaling  
  Owusu-Ansah, A., Choi, S.H., Petrosiute, A., Letterio, J.J., Huang, A.Y., Frontiers of Medicine, 1/1/2015
• Notch receptor-ligand engagement maintains hematopoietic stem cell quiescence and niche retention  
  Wang, W., Yu, S., Zimmerman, G., Wang, Y., Myers, J., Yu, V., Huang, D., Huang, X., Shim, J., Huang, Y., Xin, W., Qiao, P., Yan, M., Xin, W., Scadden, D., Stanley, P.,..., Stem Cells, 1/1/2015
• Administration of reconstituted polyphenol oil bodies efficiently suppress dendritic cell inflammatory pathways and acute intestinal inflammation  
  Cavalcanti, E., Vadrucci, E., Delvecchio, F., Addabbo, F., Bettini, S., Liou, H.-L.R., Huang, A.Y., Pizarro, T.T., Santino, A., Chieppa, M., PLoS One, 1/1/2014
• Intravital imaging of dynamic axonal interactions with microglia and macrophages in a mouse dorsal column crush injury  
  Evans, T.A., Barkauskas, D.S., Myers, J.T. Huang, A.Y., J Vis Exp, 1/1/2014
• Utilization of multiphoton imaging for real-time fate determination of mesenchymal stem cells in an immunocompetent mouse model  
  Myers, J.T., Petrosiute, A., Huang, A.Y., J Stem Cell Research & Therapy, 1/1/2014
• High-resolution intravital imaging reveals that blood derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury  
  Evans, T.A., Barkauskas, D.S., Myers, J., You, J.Q., Hare, E.G., Ransohoff, R., Silver, J., Huang, A.Y., Experimental Neurology, 1/1/2014
• Blood-derived macrophages dominate over resident microglia in mediating the neuroinflammatory response to implanted intracortical microelectrodes  
  Ravikumar, M., Sunil, S., Black, J., Barkauskas, D.S., Huang, A.Y., Miller, R.H., Selkirk, S.M., Capadona, J.R., Biomaterials, 1/1/2014
• Prevalence of hypertension and abnormal kidney function in children with Sickle Cell Disease – a cross sectional review  
  Bodas, P., Huang, A., O’Riordan, M.A., Sedor, J., Dell, K.M., BMC Nephrol, 1/1/2013
• Chemokines as Cancer Vaccine Adjuvants  
  Bobanga, I., Petrosiute, A., Huang, A.Y., Vaccines, 1/1/2013
• Dynamic Single-cell Imaging of Marrow-resident Lysozyme-expressing Myeloid Cells with Human Mesenchymal Stem Cells upon Systemic Lipopolysaccharide Challenge  
  Myers, J., Barkauskas, D., Huang, A.Y., Stem Cells International, 1/1/2013
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Books/Book Chapters

• Immunologic Disorders in Infants and Children. 
  Chapter: The immune response: Generation, regulation, and maintenance 
  Huang, A.Y.C., Rigby, M.R.Editors: Steihm, E.R., Ochs, H.D., and Winkelstein, J.A..Saunders PublishingEdition 5th,2004
• Vaccines against virally induced cancers. 
  Chapter: Bone marrow-derived cells present MHC class I-restricted tumour antigens in priming of antitumour immune responses 
  Page 229 - 244Huang, A.Y.C., Golumbek, P., Ahmadzadeh, M., Jaffee, E., Pardoll, D., Levitsky, H.Wiley, Chichester, NJ1994
• Collective Theories of the Oracle Bones. 
  Chapter: Revelation from examination of the Oracle bones revealed the motives and ceremonial worship by the Yin tribe 
  Huang, A.Y.C., Huang, Y.W., Huang, C.S.Editors: Yun, W.L and Huang, C.S..Centre for Chinese Language and Culture

Abstracts/Posters

• Quantification of lymph node transit times reveals differences in the trafficking behavior of regulatory versus conventional CD4+ T cells.
  Tong, A., Allen, F., Nair, A., Murphy, S., Huang, A.Y., CRI-CIMT-EATI-AACR Cancer Immunotherapy Conference, New York, NY, 1/25/2016
• Cdk5 disruption attenuates tumor PD-L1 expression via regulation of IFN-g signaling components and promotes anti-tumor immunity.
  Dorand, R.D., Nthale, J., Myers, J.T., Barkauskas, D.S., Avril, S., Chirieleison, S.M., Pareek, T.K., Abbott, D.W., Stearns, D.S., Letterio, J.J., Huang, A.Y., Petrosi..., CRI-CIMT-EATI-AACR Cancer Immunotherapy Conference, New York, NY, 1/25/2016
• CCL3 in the tumor microenvironment augments antitumor immune priming in the lymph node.
  Allen, F., Eid, S., Nthale, J., Myers J., Huang, A.Y., CRI-CIMT-EATI-AACR Cancer Immunotherapy Conference, New York, NY, 1/25/2016
• Fingolimod (FTY720), in clinically-safe doses, ameliorates graft-versus-host disease (GVHD) in murine model of haploidentical hematopoietic stem cell transplantation.
  Williams, B., Askew, D., Vatsayan, A., Eid, S., deLima, M., Huang, A.Y., BMT Tandem Meetings, Honolulu, HI, 1/18/2016
• Quantification of lymph node transit times reveals differences in the trafficking behavior of regulatory versus conventional CD4+ T cells.
  Tong, A., Myers, J., Nair, A., Huang, A.Y., Consequences of antigen recognition by lymphocytes block symposium, Immunology, 1/17/2016
• Positively selected enhancer elements endow tumor cells with metastatic competence.
  Morrow, J.J., Miller, T.E., Saiakhova, A., Lizardo, M.M., Bartels, C.F., Bayles, I., Hung, S., Mendoza, A., Myers, J.T., Allen, F., Difeo, A., Rubin, B.P., Huang, A.Y...., AACR, New Orleans, LA, 1/16/2016
• Role of cyclin dependent kinase 5 in T cells and acute graft versus host disease.
  Vatsayan, A., Askew, D., Eid, S., Tong, A., Allen, F., Cooke, K.R., Letterio, J.J., Huang, A.Y., ASPHO/ PBMTC, Orlando, FL, 1/12/2016
• Relapse of leukemia after bone marrow transplant is associated with donor granulocytic myeloid-derived suppressor cells.
  Askew, D., Nthale, J., Huang, A.Y., Case Comprehensive Cancer Center Annual Retreat, Cleveland, OH, 1/8/2016
• Inflammatory chemokine CCL3 in the tumor microenvironment augments the antitumor immune response.
  Allen, F., Huang, A.Y., Immunology Training Program Retreat, Case Western Reserve University, Cleveland, OH, 1/23/2015
• Relapse of leukemia after bone marrow transplant is associated with donor myeloid-derived suppressor cells.
  Askew, D., Myers, J., Dorand, D., Nthale, J., Huang, A.Y., Immunology Training Program Retreat, Case Western Reserve University, Cleveland, OH, 1/23/2015
• Cyclin Dependent Kinase-5 regulates IFNg induced PD-L1 in Medulloblastoma.
  Dorand, D., Nthale, J., Huang, A.Y., Petrosiute, A., Immunology Training Program Retreat, Case Western Reserve University, Cleveland, OH, 1/23/2015
• Homeostatic regulatory T cell trafficking in peripheral lymph nodes.
  Tong, A.A., Allen, F., Huang, A.Y., Immunology Training Program Retreat, Case Western Reserve University, Cleveland, OH, 1/23/2015
• Cyclin dependent kinase-5 regulates IFNg induced PD-L1 expression via IRF-1 in Medulloblastoma.
  Dorand, R.D., Petrosiute, A., Nthale, J., Huang, A.Y., CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference, Translating science into survival, New York, NY, 1/17/2015
• Vascular adhesion molecule 1 (VCAM-1) enhances immune evasion in metastatic osteosarcoma in vitro.
  Menocal, L., Myers, J., Scrimieri, F., Huang, A.Y., Annual Biomedical Conference for Minority Students (ABRCMS), Seattle, WA, 1/11/2015
• Inflammatory chemokine CCL3 leads to enhanced antitumor development in the draining lymph node.
  Allen, F., Bobanga, I.D., Barkauskas, D., Myers, J.T., Huang, A.Y., American Association of Immunologists (AAI) Annual Meeting, New Orleans, LA, 1/10/2015
• Role of natural killer cells in controlling Ewing Sarcoma growth.
  Hashem, H., Eid, S., Parameswaran, R., Wald, D., Huang, A.Y., Case Comprehensive Cancer Center Annual Retreat, Warrensville Heights, OH, 1/10/2015
• Homeostatic regulatory T cell trafficking in peripheral lymph nodes.
  Tong, A., Allen, F., Huang, A.Y., Case Comprehensive Cancer Center Annual Retreat, Warrensville Heights, OH, 1/10/2015
• Genetic depletion f cyclin dependent Kinase-5 results in enhanced tumor rejection via a CD4+ T cell dependent mechanism
  Dixon, R.D., Petrosiute, A., Nthale, J., Scrimieri, F., Pareek, J.K., Myers, J.T., Barkauskas, D.S., Letterio, J.J., Stearns, D. Huang, A.Y., American Association of Immunologists (AAI) Annual Meeting, New Orleans, LA, 1/10/2015
• Homeostatic regulatory T cell trafficking in peripheral lymph nodes
  Tong, A., Allen, F., Huang, A.Y., American Association of Immunologists (AAI) Annual Meeting, New Orleans, LA, 1/8/2015
• In vivo properties of plant viral nanoparticles after repeat administration.
  Woods, S., Shukla, S., Dorand, D., Myers, J.T., Huang, A.Y., Steinmetz, N.F., BMES Annual Meeting, Tampa, FL, 1/7/2015
• Cyclin Dependent Kinase 5 (Cdk5) in T cell trafficking and acute GVHD.
  Vatsayan, A., Askew, D., Eid, S., Huang, A.Y., Fellow's Science Day Presentation, UH Rainbow Babies & Children's Hospital, Cleveland, OH, 1/6/2015
• Role of natural killer cells in controlling Ewing Sarcoma growth.
  Hashem, H., Eid, S., Parameswaran, R., Wald, D., Huang, A.Y., Fellow's Science Day Presentation, UH Rainbow Babies & Children's Hospital, Cleveland, OH, 1/6/2015
• Cyclin Dependent Kinase 5 as a Marker of Disease Activity in Childhood Acute Lymphoblastic Leukemia
  Huang, A.Y., ASPHO Annual Meeting, Phoenix, AZ, 1/6/2015
• Role of natural killer cells in controlling Ewing Sarcoma growth. Platform session and poster, third annual pediatric blood and marrow transplant consortium (PBMTC)
  Hashem, H., Eid, S., Parameswaran, R., Wald, D., Huang, A.Y., ASPHO Annual Meeting, Phoenix, AZ, 1/6/2015
• Role of KLF4 in T cell Leukemia
  Bhaskaran, S., Ramakrishna, A., Huang, A.Y., Jain, M., Letterio, J., ASPHO Annual Meeting, Phoenix, AZ, 1/6/2015
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Lectures

• Human Bone Marrow Derived Mesenchymal Stromal Cells Enhance the Number and Function of Umbilical Cord Blood Peripheral Tregs during IL-2 Driven Ex Vivo Expansion 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Exciting era of tumor immunology and immunotherapy 
  Albert Einstein College of Medicine, Einstein-Montefiore Clinical Research Center, Bronx, NY - 1/30/2017
• Cdk5 as a new immunotherapeutic target 
  Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY - 1/20/2017
• The truth is more important than the facts 
  University of Chicago, Chicago, IL - 1/19/2017
• Cdk5: A new modulator of immune response 
  Johns Hopkins University School of Medicine, Baltimore, MD - 1/10/2017
• Tumor Immunology. 
  1/1/2017
• Lymphocyte Migration and Homing. 
  1/1/2017
• The Immune Response in Space and Time. 
  1/1/2017
• Cell-Mediated Immunity. 
  1/1/2017
• Basis for Anti-Tumor Immunotherapy. 
  1/1/2017
• Scholarship Activity & Grants Mechanisms. 
  1/1/2017
• Regulating Tumor Immune Surveillance 
  Boston, MA - 1/29/2016
• Immunotherapy: Harnessing the Power of the Immune System to Fight Cancer 
  Cleveland, OH - 1/25/2016
• Discovering new targets for tumor immune surveillance. 
  Changhua Christian Hospital, Changhua, Taiwan - 1/23/2016
• Role of Cyclin-dependent Kinase 5 As an Immune Regulator 
  Cleveland, OH - 1/19/2016
• Enhancing Tumor Immune Surveillance 
  Cambridge Healthtech Institute, Philadelphia, PA - 1/18/2016
• Cdk5: A new immune checkpoint molecule 
  Cincinnati Children’s Hospital, Cincinnati, OH - 1/18/2016
• New Science in Transplant Immunology 
  Honolulu, HI - 1/17/2016
• Progress of Immunotherapy in Childhood Cancers 
  1/14/2016
• Immunotherapy in Pediatric Malignancies 
  Cleveland, OH - 1/11/2016
• Immunotherapy and Cell-based Therapies 
  Cleveland, OH - 1/8/2016
• Discovering New Targets for Tumor Immune Surveillance 
  University of Michigan C.S. Mott Children's Hospital, Ann Arbor, MI - 1/6/2016
• Cancer Immune Cell Therapy: Unraveling the mystery of how our immune system can fight cancer 
  Cleveland, OH - 1/4/2016
• Priniciples of Tumor Immunology & Immunotherapy i.e. Crash Course in Immunology 
  Cleveland, OH - 1/1/2016
• Assessing dynamic tissue microenvironment with 2-PM: Cell Migration and Interaction in the CNS, spine, bone marrow and lymph node 
  Cleveland, OH - 1/24/2015
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