AlanMichaelKrenskyMD

PubMed

• 220 citations
  Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins.
  Susan V. Peña, Dennis A. Hanson, Brian A. Carr, Thomas J. Goralski, Alan M. Krensky
  Journal of Immunology. 1997-03-15
• 813 citations
  An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
  Steffen Stenger, Dennis A. Hanson, Rachel Teitelbaum, Puneet Dewan, Kayvan Niazi
  Science. 1998-10-02
• 458 citations
  The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.
  Alan M. Krensky, Francisco Sánchez-Madrid, Elizabeth Robbins, Janice A. Nagy, Timothy A. Springer
  Journal of Immunology. 1983-08-01

Journal Articles

• A human class II derived peptide antagonizes phosphatidyl 3-kinase to block IL-2 signaling.  
  Boytim, M. L., Lilly, P., Drouvalakis, K., Lyu, S.-C., Jung, R., Krensky, A. M., Clayberger, C, J. Clin. Invest
• Identification of epitopes of Mycobacterium tuberculosis 16kDa protein recognized by human leukocyte antigen A*0201 CD8+ T lymphocytes.  
  Caccamo N, Milano S, Di Sano C, Cigna D, Ivanyi J, Krensky AM, Dieli F, Salerno A, J. Infec. Dis
• DQ 65-79, a peptide derived from HLA Class II, induces IkB expression.  
  Jiang Y, Chen D, Lyu S-C, Ling X, Krensky AM, Clayberger C, J. Immunol
• A T cell specific enhancer of the human CD40 ligand gene.  
  Schubert LA, Cron RQ, Cleary AM, Song A, Lu L-S, Jullien P. Krensky AM, Lewis DB, J. Biol. Chem
• Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vg9/Vd2 T lymphocytes.  
  Dieli F, Troye-Blomberg M, Ivanyi J, Fournié JJ, Krensky AM, Bonneville M, Peyrat MA, Caccamo N, Sireci G, SalernoA, J. Infect. Dis
• A role of the mitochondrial apoptosis inducing factor (AIF) in granulysin-induced apoptosis.  
  Pardo J, Perez-Galan P, Gamen S, Marzo I, Monleon I, Kaspar A, Susin SA, Kroemer G, Krensky AM, Naval J, Anel A, J. Immunol
• A distinct pathway of cell-mediated apoptosis initiated by granulysin.  
  Kaspar AA, Poulain FR, Kelekar A, Hanson DA, Hitoshi Y, Johnson DE, Froelich C, Thompson CB, Anel A, Clayberger C, Krensky AM, J. Immunol
• A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection.  
  Horuk R, Clayberger C, Krensky AM, Wang Z, Grone H-J, Weber C, Weber KSC, Nelson PJ, May K, Rosser M, Dunning L, Liang M, Buckman B, Ghannam A, Ng HP, Islam I, Bauman..., J. Biol. Chem
• The immune tolerance network: The "holy grail" comes to the clinic.  
  Bluestone JA, Matthews JB, Krensky AM, J. Am. Soc
• The immune tolerance network: The "holy grail" comes to the clinic.  
  Bluestone JA, Matthews JB, Krensky AM, J. Am. Soc
• Granulysin, a T cell product, kills bacteria by altering membrane permeability.  
  Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL, J. Immunol
• Bactericidal and tumorcidal activities of synthetic peptides derived from granulysin.  
  Wang Z, Choice E, Kaspar A, Hanson D, Okada S, Lyu S-c, Krensky AM, Clayberger C, J. Immunol
• Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Kruppel-like transcription factor of activated T lymphocytes.  
  Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM, J. Biol. Chem
• Interleukin-1β induction of the chemokine RANTES promoter in the human astrocytoma line CH235.  
  Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD, J. Neuroimmunol
• Proliferating cell nuclear antigen as the cell cycle sensor for an HLA derived peptide blocking T cell proliferation.  
  Ling X, Kamangar S, Boytim ML, Kelman Z, Huie P, Lyu-S-C, Sibley RK, Hurwitz J, Clayberger C, Krensky AM, J. Immunol
• Self recognition of CD1 by γδ T cells: implications for innate immunity.  
  Spada FM, Grant EP, Peters PJ, Sugita M, Melian A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB, J. Exp. Med
• Transfer of specific unresponsiveness to organ allografts by thymocytes.  
  Krensky AM: Guest Commentary, J. Am. Soc. Nephrol
• The allocation of cadaver Kidneys for transplantation in the United States: Consensus and controversy.  
  Neylan JF, Sayegh MH, Coffman TM, Danovich GM, Krensky AM, Strom TB, Turka LA, Harmon WE, J. Am. Soc. Nephrol
• HLA derived peptides as novel immunomodulatory therapeutics.  
  Murphy B, Krensky AM, J. Am. Soc. Nephrol
• Granulysin induced apoptosis. I. Involvement of at least two distinct pathways.  
  Gamen S, Hanson DA, Naval J, Krensky AM, Anel A, J. Immunol
• Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence.  
  Boytim ML, Lyu S-C, Jung R, Krensky AM, Clayberger C, J. Immunol
• New insights into mechanisms of allograft rejection.  
  Pattison JM, Krensky AM, Am. J. Med. Sci
• Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small lytic granule proteins.  
  Pena SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM, J. Immunol
• RANTES chemokine expression in transplant associated atherosclerosis.  
  Pattison JM, Nelson PJ, Huie P, Sibley RK, Krensky AM, J. Heart Lung Transplant
• Granulysin-mediated tumor rejection in transgenic mice.  
  Huang LP, Lyu S-C, Clayberger C, Krensky AM, J. Immunol
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Books/Book Chapters

• Mechanisms of allograft rejection. 
  Chapter: Immunologic Renal Diseases 
  Page 321 - 346Clayberger C, Krensky AMEditors: Neilson EG, Couser WG.Lippincott Williams and Wilkins, PhiladelphiaEdition 2nd,
• Transplantation Immunobiology. 
  Chapter: Pediatric Nephrology 
  Page 1289 - 1307Krensky AMEditors: Barratt TM, Avner ED and Harmon W.Williams and Wilkins, Baltimore
• T cell immunity. 
  Chapter: Hematology: Basic Principles and Practice 
  Page 90 - 100Clayberger C, Krensky AMEditors: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P.Churchill Livingstone, New YorkEdition 3rd,
• Immunologic principles of transplantation. 
  Chapter: Principles of Nephrology 
  Page 1 - 12Pavlakis M, Krensky AMEditors: Johnson RJ, Feehally J. Mosby Intl, London
• Cytotoxic and antimicrobial proteins of cytolytic lymphocytes. 
  Chapter: Cytotoxic Cells: Basic Mechanisms and Medical Applications 
  Page 213 - 227Hanson D, Krensky AM: Granulysin and NK-lysinEditors: Sitkovsky MV, Henkart PA.Lippincott-Williams & Wilkins, Philadelphia
• Transcriptional Regulation of Chemokines. 
  Chapter: Chemokines in Allergic Disease 
  Page 115 - 136Chen Y-F, Song A, Krensky AMEditors: Rothenberg ME.Marcel Dekker, New York
• Transplantation immunobiology. 
  Chapter: Dialysis and Transplantation: A Companion to Brenner and Rector’s The Kidney 
  Page 487 - 498Sayegh MH, Krensky AMEditors: Owen WF, Periera BJG, Sayegh MH.W.B. Saunders Co, Orlando, FL
• Immune response to allografts. 
  Chapter: The ASTP Primer on Transplantation 
  Page 17 - 26Krensky AMEditors: Norman DJ, Turka T.American Society of Transplant Physicians, Thorofare, NJEdition 2nd,
• Costimulation. 
  Chapter: Pediatric Solid Organ Transplantation 
  Page 26 - 34Sarwal M, Krensky AMEditors: Fine RN, Tejani A.Munksgaard, Copenhagen
• The HLA-T-cell interaction in transplant rejection. 
  Chapter: Organ Transplantation 
  Page 435 - 445Krensky AM, Clayberger CEditors: Stuart FP, Abecassis MM, Kaufman DB.Landes Bioscience, Georgetown, TX
• HLA derived peptides as novel immunomodulatory therapeutics. 
  Chapter: Clinical Transplantation Immunology 
  Page 508 - 521Murphy B, Krensky AMEditors: R. Duquesnoy and Y. Li.Science Pres, PR China
• Immunomodulatory function of MHC peptides. 
  Chapter: Current and Future Immunosuppression Therapies Following Transplantation 
  Page 279 - 292Murphy B, Krensky AMEditors: Sayegh M and Remuzzi G.Kluwer Academic Publishers
• Immunology and genetics of transplantation. 
  Chapter: Textbook of Nephrology Fourth Edition 
  Page 1601 - 1610Krensky AM, Clayberger CEditors: Massry SG, Glassock RJ.Lippincott Williams and Wilkins, Philadelphia
• The RANTES chemokine. 
  Chapter: Cytokines 
  Page 434 - 448Nelson PJ, Pattison JM, Krensky AMEditors: Mire-Sluis A and Thorpe R.Academic Press
• Granulysin, a novel mediator of antimicrobial activity of cytolytic T-cells. 
  Chapter: Development of novel antimicrobial agents: Emerging strategies 
  Page 61 - 69Stenger S, Krensky AM, Modlin RLEditors: Lohner K.Horizon Scientific Press, Wymondham, UK
• Immunomodulators: Immunosuppressive Agents, Tolerogens, and Immunostimulants. 
  Chapter: Goodman & Gilman’s The Pharmacological Basis of Therapeutics 
  Page 1463 - 1484Krensky AM, Strom TB, Bluestone JAEditors: Hardman JG, Limbird LE.McGraw-Hill, PhiladelphiaEdition 10th,
• Transplantation Immunobiology. 
  Chapter: Pediatric Nephrology 
  Page 1411 - 1436Krensky AM, Clayberger CEditors: Avner ED, Harmon W and Niaudet P.Lippincott Williams & Wilkins, BaltimoreEdition 5th,
• Transplantation Immunobiology. 
  Chapter: Chronic Kidney Disease: Dialysis and Transplantation 
  Page 611 - 622Najafian N, Krensky AM, Sayegh MHEditors: Periera BJG, Sayegh MH, Blake P.Elsevier, PhiladelphiaEdition 2nd,
• T cell and NK cell immunity. 
  Chapter: Hematology: Basic Principles and Practice 
  Page 135 - 147Clayberger C, Krensky AMEditors: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P.Churchill Livingstone, New YorkEdition 4th,
• Immunomodulators: Immunosuppressants, Tolerogens, and Immunostimulants. 
  Chapter: Goodman & Gilman’s The Pharmacological Basis of Therapeutics 
  Page 1405 - 1431Krensky AM, Vincenti F, Bennett WEditors: Brunton LL.McGraw-Hill, PhiladelphiaEdition 11th,
• Mechanisms of action of immunosuppressive agents. 
  Chapter: Pediatric Solid Organ Transplantation 
  Page 69 - 76Krensky AMEditors: Fine RN, Webber S, Harmon W, Kelly D, Olthoff K.Blackwell, OxfordEdition 2nd,
• Building the research infrastructure. 
  Chapter: Redesigning the Clinical Effectiveness Research Paradigm 
  Page 343 - 353Krensky AMEditors: Olsen L and McGinnis M.National Academies Press, Washington DC
• Organizing the research community for change: Opportunities for action. 
  Chapter: Redesigning the Clinical Effectiveness Research Paradigm 
  Page 365 - 377McClellan MB, Krensky AM, Neil G, Niederhuber J, Sandy LEditors: Olsen L and McGinnis M.National Academies Press, Washington DC
• Chemokines and cytotoxic effector molecules in rejection. 
  Chapter: Signatures of Immune Rejection 
  Page 77 - 92Krensky AM, Clayberger CEditors: Wang E, Marincola FM.Springer, New York
• Immunosuppressants, Tolerogens, and Immunostimulants. 
  Chapter: Goodman & Gilman’s The Pharmacological Basis of Therapeutics 
  Page 1005 - 1029Krensky AM, Bennett WM, Vincenti FEditors: Brunton LL.McGraw-Hill, New YorkEdition 12th,
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Other

• Tail positions of Cercopithecus aethiops. 
  Bernstein PW, Smith WJ, Krensky A, Rosene K, Z. Tierpsychol
• HLA antigens in mucocutaneous lymph node syndrome in New England. 
  Krensky AM, Berenberg W, Shanley K, Yunis EJ, Pediatrics
• Elevated nephrogenous cyclic adenosine monophosphate to monitor early renal osteodystrophy. 
  Krensky AM, Harmon WE, Ingelfinger JR, Kirkpatrick JR, Grupe WE, Clin. Nephrology
• Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. 
  Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA, Proc. Natl. Acad. Sci
• Hemolytic Uremic Syndrome and Crescentic Glomerulonephritis complicating childhood nephrosis. 
  Krensky AM, Ingelfinger JR, Grupe WE, and Rosen S, Clin. Nephrology
• Epidemic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome. 
  Krensky AM, Grady S, Shanley KM, Berenberg W, Yunis EJ, Human Immunology
• Causes of increased renal echogenicity in pediatric patients. 
  Krensky AM, Reddish J, Teele RL
• Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. 
  Pober JS, Collins T, Gimbrone MA, Cotran RS, Gitlin J, Fiers W, Clayberger C, Krensky AM, Burakoff SJ, Reiss CS
• Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. 
  Burakoff SJ, Clayberger C, Hemler M, Krensky AM, Reiss CS, Robbins E, Sanchez-Madrid F, Springer TA, Strominger JL, Ware CF, Diag. Immunol
• Human lymphocyte function associated antigens. 
  Krensky AM, Sanchez-Madrid F, Springer TA, and Burakoff SJ, Survey of Immunological Research
• Production of colony stimulating factor(s) for granulocyte-macrophage and multipotential granulocyte/erythroid/megakaryocyte/macrophage hematopoietic progenitor cells... 
  Greenberger JS, Krensky AM, Messner H, Burakoff SJ, Wandt U, Sakakenny MA, Exp. Hematology
• Interaction of T lymphocytes with human vascular endothelial cells: Role of endothelial cells surface antigens. 
  Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss CS, Burakoff SJ, Immunobiol
• Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor. 
  O’Flynn K, Krensky AM, Beverly PCL, Burakoff SJ, and Linch DS, Nature
• Species-specific cytotoxic T lymphocyte recognition of major histocompatibility antigens HLA-A2 and HLA-B7 after DNA-mediated gene transfer. 
  Mentzer SJ, Barbosa JA, Krensky AM, Biro PA, Strominger JL, Burakoff SJ, Transpl. Proc
• Diagnostic and therapeutic implications of T cell surface antigens. 
  Krensky AM, Clayberger C, Transplantation
• The human cytolytic T lymphocyte response to transplantation antigens. Transcript of the third annual Society for Pediatric Research Young Investigator Award present... 
  Krensky AM, Pediatr. Res
• Lymphocyte subsets and surface molecules in man. 
  Krensky AM, Lanier LL, Engleman EG, Clinical Immunology Reviews
• MHC-unrestricted cytolytic T lymphocytes. 
  Krensky AM, Clayberger C, Survey of Immunological Research
• Mapping functional epitopes of the human LFA-1 glycoprotein: Monoclonal antibody inhibition of NK and CTL effectors. 
  Mentzer S, Krensky AM, Burakoff SJ, Human Immunology
• The modulation of generation/function of human cytotoxic lymphocytes by autocoids: Unusually compartmentalized cAMP? 
  Kahn MM, Keaney KM, Krensky AM, Melmon KL, Proc. West Pharmacol. Soc
• Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the alpha2 domain of HLA-A2. 
  Parham P, Clayberger C, Zorn SL, Ludwig DS, Schoolnik GK, Krensky AM, Nature
• Rhabdomyolysis complicating doxylamine overdose. 
  Mendoza FS, Atiba JO, Krensky AM, Scannell LM, Clin. Pediatrics
• Expression of Leu 19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines. 
  Lanier LL, Le AM, Ding A, Evans EL, Krensky AM, Clayberger C, Phillips, JH, J. Immunol
• Absence of cell surface LFA-1 as a mechanism of escape from immunosurveillance. 
  Clayberger C, Wright A, Medeiros LJ, Koller TD, Link MP, Smith SD, Warnke RA, Krensky AM, Lancet
• HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes. 
  Clayberger C, Parham P, Rothbard J, Ludwig DS, Schoolnik GK, Krensky AM, Nature
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