DorisGay YeeLeungMDPhD

Neurology • Baltimore, MD

Neuromuscular Medicine, Neurophysiology

Associate Professor of Neurology, Johns Hopkins University School of Medicine

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Office
716 N. Broadway
Suite 411
Baltimore, MD 21205
Phone+1 410-550-5624

Fax+1 443-923-9545
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Education & Training

Johns Hopkins Bloomberg School of Public HealthPhD, Clinical Investigation, 2013 - 2016
Johns Hopkins University School of MedicinePost-Doctoral Fellowship, Translational Research in Muscular Dystrophy, 2010 - 2014
Stanford Health Care-Sponsored Stanford UniversityFellowship, Clinical Neurophysiology, 2009 - 2010
Stanford Health Care-Sponsored Stanford UniversityResidency, Neurology, 2006 - 2009
Duke University HospitalInternship, Internal Medicine, 2005 - 2006
Duke University School of MedicineClass of 2005
Harvard UniversityBA, Biochemical Sciences, Magna cum laude, 1997 - 2001

Certifications & Licensure

MD State Medical License 2010 - 2024
CA State Medical License 2007 - 2010
NC State Medical License 2005 - 2006
American Board of Psychiatry and Neurology Neurology
American Board of Psychiatry and Neurology Clinical Neurophysiology

Clinical Trials

Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy Start of enrollment: 2012 Mar 01
Active, not recruiting
Safety Study of Eteplirsen to Treat Advanced Stage Duchenne Muscular Dystrophy Start of enrollment: 2014 Nov 01
Completed
Phase 2
A Phase 2 Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of PF-06252616 in Duchenne Muscular Dystrophy Start of enrollment: 2014 Nov 24
Terminated
Phase 2
A Safety andTolerability Study of Multiple Doses of ISIS-DMPKRx in Adults With Myotonic Dystrophy Type 1 Start of enrollment: 2014 Dec 01
Completed
Phase 1, Phase 2
Safety Study of Eteplirsen to Treat Early Stage Duchenne Muscular Dystrophy Start of enrollment: 2015 Jun 30
Completed
Phase 2
Study of an Investigational Drug, RO7239361 (BMS-986089), in Ambulatory Boys With DMD Start of enrollment: 2015 Dec 02
Terminated
Phase 1, Phase 2
Dose-Titration and Open-label Extension Study of SRP-4045 in Advanced Stage Duchenne Muscular Dystrophy (DMD) Patients Start of enrollment: 2015 Oct 08
Completed
Phase 1
Evaluate Safety and Biological Activity of ATYR1940 in Participants With Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Facioscapulohumeral Muscular Dystrophy (FSHD) Start of enrollment: 2015 Nov 30
Completed
Phase 1, Phase 2
A Trial of PF-06252616 in Ambulatory Participants With LGMD2I Start of enrollment: 2016 Jul 01
Completed
Phase 1, Phase 2
Study to Evaluate the Efficacy and Safety of BBP-418 (Ribitol) in Patients With Limb Girdle Muscular Dystrophy 2I (LGMD2I) Start of enrollment: 2023 May 31
Recruiting
Phase 3
Roles: Contact, Principal Investigator
A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1) Start of enrollment: 2023 Mar 12
Recruiting
Phase 1, Phase 2
Defining Endpoints in Becker Muscular Dystrophy Start of enrollment: 2022 Apr 13
Recruiting
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD) Start of enrollment: 2019 Jun 14
Recruiting
Oral Ifetroban in Subjects With Duchenne Muscular Dystrophy Start of enrollment: 2020 Oct 19
Recruiting
Phase 2
Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) Start of enrollment: 2020 Dec 15
Recruiting
Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD Start of enrollment: 2018 Mar 05
Active, not recruiting
Biomarker Development in LGMD2i Start of enrollment: 2019 Dec 01
Completed
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Publications & Presentations

PubMed

1 citations
Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial.
Rabi Tawil, Kathryn R Wagner, Johanna I Hamel, Doris G Leung, Jeffrey M Statland, Leo H Wang, Angela Genge, Sabrina Sacconi, Hanns Lochmüller, David Reyes-Leiva, Jordi...> ;The Lancet. Neurology. 2024 May 1
4 citations
Comparative effectiveness study of flipped classroom versus online-only instruction of clinical reasoning for medical students.
Ashley Paul, Doris Leung, Rachel Marie E Salas, Tiana E Cruz, Chadia Abras, Deanna Saylor, Veronique Gugliucciello, Jaqueline Nunn, Charlene E Gamaldo, Roy E Strowd> ;Medical Education Online. 2023 Dec 1
1 citations
Lean tissue mass measurements by dual-energy X-ray absorptiometry and associations with strength and functional outcome measures in facioscapulohumeral muscular dystro...
Leung, D. G., Leo H Wang, Doris G Leung, Kathryn R Wagner, Sarah J Lowry, Michael P McDermott, Katy Eichinger, Kiley Higgs, Michaela Walker, Leann Lewis, William B Mar...> ;Neuromuscular Disorders. 2023 Sep 1
A comprehensive study of skeletal muscle imaging in FHL1-related reducing body myopathy.
Payam Mohassel, Pomi Yun, Safoora Syeda, Abhinandan Batra, Andrew J Bradley, Sandra Donkervoort, Soledad Monges, Julie S Cohen, Doris G Leung, Francina Munell, Carlos ...> ;Annals of Clinical and Translational Neurology. 2023 Aug 1
7 citations
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial.
Charles A Thornton, Richard Thomas Moxley 3rd, Katy Eichinger, Chad Heatwole, Laurence Mignon, W David Arnold, Tetsuo Ashizawa, John W Day, Gersham Dent, Matthew K Tan...> ;The Lancet. Neurology. 2023 Mar 1
Meeting report: The 2022 FSHD International Research Congress.
Leung DG, Kinoshita J, Arjomand J, Dumonceaux J, 2022 FSHD IRC Program committee and co-chairs> ;Neuromuscular disorders : NMD. 2022-12-13
9 citations
Antisense Oligonucleotide Therapy for the Nervous System: From Bench to Bedside with Emphasis on Pediatric Neurology.
Man Amanat, Christina L Nemeth, Amena Smith Fine, Doris G Leung, Ali Fatemi> ;Pharmaceutics. 2022 Nov 5
4 citations
Broadening learning communities during COVID-19: developing a curricular framework for telemedicine education in neurology
Christine E. Gummerson, Brian D. Lo, Kori A. Porosnicu Rodriguez, Zoe L. Cosner, Dylan Hardenbergh, Diana M. Bongiorno, Julia Wainger, Katherine Hu, Charlene E. Gamald...> ;BMC Medical Education. 2021 Oct 29
10 citations
Long Term Extension Study of Tofacitinib in Refractory Dermatomyositis.
Julie J. Paik, Matthew Shneyderman, Laura Gutierrez-Alamillo, Jemima Albayda, Eleni Tiniakou, Jamie Perin, Grazyna Purwin, Sherry Leung, Doris G. Leung, Livia Casciola...> ;Arthritis & Rheumatology. 2021 Aug 9
5 citations
A phase Ib/IIa, open-label, multiple ascending-dose trial of domagrozumab in fukutin-related protein limb-girdle muscular dystrophy.
Doris G. Leung, Alex E. Bocchieri, Shivani Ahlawat, Michael A. Jacobs, Vishwa S. Parekh, Vladimir Braverman, Katherine Summerton, Jennifer Mansour, Nikia Stinson, Geni...> ;Muscle & Nerve. 2021 May 24
74 citations
Study of Tofacitinib in Refractory Dermatomyositis: An Open-Label Pilot Study of Ten Patients.
Julie J. Paik, Livia Casciola-Rosen, Joseph Y. Shin, Jemima Albayda, Eleni Tiniakou, Doris G. Leung, Laura Gutierrez-Alamillo, Jamie Perin, Liliana Florea, Corina Anto...> ;Arthritis & Rheumatology. 2021 May 1
7 citations
Longitudinal functional and imaging outcome measures in FKRP limb-girdle muscular dystrophy.
Doris G. Leung, Alex E. Bocchieri, Shivani Ahlawat, Michael A. Jacobs, Vishwa S. Parekh, Vladimir Braverman, Katherine Summerton, Jennifer Mansour, Genila Bibat, Carl ...> ;BMC Neurology. 2020 May 19
15 citations
Advancements in magnetic resonance imaging‐based biomarkers for muscular dystrophy
Doris G. Leung> ;Muscle & Nerve. 2019 May 14
5 citations
When Control Exacerbates Distress: A Qualitative Study Exploring the Experiences of Hong Kong Chinese Parents in Caring for a Child with Asthma
Yuen Yu Chong, Doris G. Leung, Yim Wah Mak> ;International Journal of Environmental Research and Public Health. 2018 Jun 30
4 citations
Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy
Doris G. Leung, Xin Wang, Peter B. Barker, John A. Carrino, Kathryn R. Wagner> ;Muscle & Nerve. 2018 Jun 1
4 citations
Mitochondrial DNA Deletions With Low-Level Heteroplasmy in Adult-Onset Myopathy.
Doris G. Leung, Julie S. Cohen, Elizabeth Harlan Michelle, Renkui Bai, Andrew L. Mammen, Lisa Christopher-Stine> ;Journal of Clinical Neuromuscular Disease. 2018 Mar 1
6 citations
Magnetic resonance imaging in facioscapulohumeral muscular dystrophy.
Doris G. Leung> ;Muscle & Nerve. 2018 Jan 23
2 citations
Myopathy: Recent Progress, Current Therapies, and Future Directions.
Andrew L. Mammen, Ricardo H. Roda, Doris G. Leung> ;Neurotherapeutics. 2018 Oct 1
5 citations
Exploring research cultures through internationalization at home for doctoral students in Hong Kong and Sweden.
Doris Y Leung, Elisabeth Carlson, Enid E.Y. Kwong, Ewa Idvall, Christine Kumlien> ;Nursing & Health Sciences. 2017 Sep 8
Erratum: Advanced MRI Techniques for Muscle Imaging.
Vivek Kalia, Doris G. Leung, Darryl B. Sneag, Filippo Del Grande, John A. Carrino> ;Seminars in Musculoskeletal Radiology. 2017 Oct 12
20 citations
Advanced MRI Techniques for Muscle Imaging.
Vivek Kalia, Doris G. Leung, Darryl B. Sneag, Filippo Del Grande, John A. Carrino> ;Seminars in Musculoskeletal Radiology. 2017 Aug 3
6 citations
Transitions to end-of-life care for patients with chronic critical illness : a meta-synthesis
Doris Y. P. Leung, Jan E. Angus, Tasnim Sinuff, Sherri Bavly, Louise Rose> ;The American Journal of Hospice & Palliative Care. 2017 Sep 1
19 citations
Nursing patients with chronic critical illness and their families: a qualitative study.
Doris Y Leung, Margaret Blastorah, Linda Nusdorfer, Angie Jeffs, Judy Jung, Doris Howell, Lise Fillion, Louise Rose> ;Nursing in Critical Care. 2017 Jul 1
43 citations
Magnetic resonance imaging patterns of muscle involvement in genetic muscle diseases: a systematic review
Doris G. Leung> ;Journal of Neurology. 2017 Jul 1
52 citations
Association of severity of illness and intensive care unit readmission: A systematic review
Evan G. Wong, Ann M. Parker, Doris G. Leung, Emily P. Brigham, Alicia I. Arbaje> ;Heart & Lung. 2016 Jan 1
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Professional Memberships

Hospital Affiliations

Kennedy Krieger InstituteBaltimore, Maryland
Johns Hopkins HospitalBaltimore, Maryland

External Links

Johns Hopkins Physicianshttp://www.hopkinsmedicine.org/doris-leung
Kennedy Krieger Institutehttps://www.kennedykrieger.org/patient-care/faculty-staff/doris-leung